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Found 54 clinical trials
Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations

This phase II trial studies how well olaparib works in treating patients with biliary tract cancer that has spread to other places in the body (metastatic) and with aberrant DNA repair gene mutations. Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell …

follicle stimulating hormone
olaparib
absolute neutrophil count
metastatic biliary tract cancer
serum pregnancy test
  • 0 views
  • 16 May, 2022
  • 4 locations
Onabotulinum Toxin A in Direct Brow Lift

mechanisms include increased apoptosis and suppressed proliferation of fibroblasts treated with botulinum toxin, modulated via the PTEN/PI3K/Akt pathway. Park et al added to the in vitro literature by

  • 0 views
  • 03 Feb, 2021
  • 1 location
Bortezomib in Intrahepatic Cholangiocellular Carcinoma

This study evaluates the efficacy and safety of second-line treatment of bortezomib in advanced intrahepatic cholangiocarcinoma patients.Half of participants will receive bortezomib while the other half will receive best supporting care.

cholangiocarcinoma
oxaliplatin
gemcitabine
cisplatin/gemcitabine
measurable disease
  • 2 views
  • 25 Feb, 2022
  • 1 location
Testing the Addition of Copanlisib to Usual Treatment (Fulvestrant and Abemaciclib) in Metastatic Breast Cancer

This phase I/II trial studies the effects (good and bad) of adding copanlisib to the usual therapy of fulvestrant and abemaciclib in treating patients with hormone receptor positive and HER2 negative stage IV breast cancer. Some breast cancer cells have receptors for the hormones estrogen or progesterone. These cells are …

everolimus
metastasis
measurable disease
endocrine therapy
stage iv breast cancer
  • 0 views
  • 11 Mar, 2022
  • 10 locations
Abemaciclib and Letrozole in Treating Patients With Endometrial Cancer

This early phase I trial studies how well abemaciclib and letrozole work in treating patients with endometrial cancer and determines whether there are changes in patients' cancer cell biomarkers (a genetic feature or specific protein) for cell growth before and after treatment. Antihormone therapy with aromatase inhibitors, such as letrozole, …

  • 2 views
  • 15 Feb, 2022
  • 1 location
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

This phase II trial studies how well vismodegib, focal adhesion kinase (FAK) inhibitor GSK2256098, and capivasertib work in treating patients with meningioma that is growing, spreading, or getting worse (progressive). Vismodegib, FAK inhibitor GSK2256098, capivasertib, and abemaciclib may stop the growth of tumor cells by blocking some of the enzymes …

vismodegib
gsk2256098
tumor cells
  • 4 views
  • 03 May, 2022
  • 517 locations
Phase II Trial of Talazoparib in BRCA1/2 Wild-type HER2-negative Breast Cancer and Other Solid Tumors

The aim of this single-arm phase 2 clinical trial is to evaluate the anti-cancer activity of Talazoparib (also known as BMN 673) in patients with advanced breast cancer with specific genetic or tumor genomic alterations. Patients with either triple-negative or HER2-negative breast cancer are eligible.

estrogen receptor
talazoparib
metastasis
progesterone receptor
chemotherapy regimen
  • 5 views
  • 08 Sep, 2021
  • 1 location
A Trial of Ipatasertib in Combination With Atezolizumab (IceCAP)

This is a single centre, proof-of-concept phase I trial of atezolizumab in combination with ipatasertib. There are two parts to this study, the dose escalation phase (Part A) and the dose expansion phase (Part B). Part A, will determine the maximum tolerated dose (MTD) and recommended Phase II dose (RP2D). …

cancer
aptt
serum bilirubin
PTEN
platelet count
  • 125 views
  • 22 Apr, 2022
  • 1 location
Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer

This phase II trial studies the effect of megestrol acetate alone or in combination with metformin in preventing the progression of uterine pre-cancer (endometrial intraepithelial neoplasia) to endometrial cancer. Megestrol acetate is a drug used to block estrogen and suppress the effects of estrogen and androgens. It is the current …

hyperplasia
uterine disease
insulin
megestrol
cancer
  • 0 views
  • 06 May, 2022
  • 5 locations
Intestinal Stem Cells Characterization (BIODIGE)

A monocentric pilot studying intestinal organoids from endoscopic biopsies of IBD (Crohn and ulcerative colitis), FAP patients and healthy controls. Investigate the morphological characteristics of organoids, the expression of genes and proteins of the Wnt/APC/beta-catenin pathway within both ISC.

ulceration
crohn's disease
Accepts healthy volunteers
ulcerative colitis
colitis
  • 8 views
  • 25 May, 2022
  • 1 location