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Found 55 clinical trials
Neoadjuvant Androgen Deprivation Darolutamide and Ipatasertib in Men With Localized High Risk Prostate Cancer

ipatasertib administered in combination with darolutamide; and a phase II neoadjuvant stage in which patients with high risk prostate cancer and loss of PTEN expression in the tumor tissue planning on

  • 0 views
  • 03 Nov, 2021
  • 1 location
Phase I Study of AZD5363 + Olaparib + Durvalumab in Patients With Advanced or Metastatic Solid Tumor Malignancies

>To explore molecular correlates of the relationship between mutations in Akt/ PIK3CA/PTEN pathway and response to AZD5363 +Olaparib+ Durvalumab To understand the role of tumour

  • 0 views
  • 22 Jan, 2021
  • 1 location
Everolimus in Treating Patients With Recurrent or Progressive Low-Grade Glioma

RATIONALE: Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. PURPOSE: This phase II trial is studying how well everolimus works in treating patients with recurrent or progressive low-grade glioma.

  • 24 views
  • 07 Nov, 2020
  • 1 location
Dose-Escalation and Efficacy Study of LAE001/Prednisone Plus Afuresertib Patients With m-CRPC

The combination treatment of protein kinase B (AKT) inhibitor, afuresertib, with androgen synthesis enzyme inhibitor, LAE001, may provide an effective treatment for metastatic castration resistant prostate cancer (m-CRPC) patients who have progressed/drug resistant following prior standard care treatments of any anti-androgen. This study intends to identify the most appropriate combined …

androgen
testosterone
bone scan
cabazitaxel
platelet count
  • 149 views
  • 04 Jun, 2022
  • 12 locations
Study With Afuresertib and Paclitaxel in Platinum Resistant Ovarian (PROFECTA-II)

Afuresertib is an AKT inhibitor, a new class of agents under development that may provide physicians with a new clinical option to control platinum resistant ovarian cancer (PROC) progression. Afuresertib plus chemotherapy has demonstrated anti-tumor efficacy and an acceptable safety profile in patients with PROC in a published Phase I/II …

  • 21 views
  • 04 Jun, 2022
  • 30 locations
TAS-117 in Patients With Advanced Solid Tumors Harboring Germline PTEN Mutations

(excluding primary brain tumors) harboring germline PTEN inactivating mutations.

  • 0 views
  • 01 May, 2022
  • 7 locations
Capivasertib+Abiraterone as Treatment for Patients With Metastatic Hormone-sensitive Prostate Cancer and PTEN Deficiency (CAPItello-281)

/prednisolone) plus ADT in participants with mHSPC whose tumours are characterised by PTEN deficiency. The intention of the study is to demonstrate that in participants with mHSPC, the combination of

  • 279 views
  • 02 Jul, 2022
  • 230 locations
Study Assessing the Efficacy and Safety of Alpelisib + Nab-paclitaxel in Subjects With Advanced TNBC Who Carry Either a PIK3CA Mutation or Have PTEN Loss (EPIK-B3)

) who carry either a PIK3CA mutation (Study Part A) or have PTEN loss (Study Part B1) or PTEN loss without PIK3CA mutation (Study Part B2)

PTEN
paclitaxel
breast cancer
measurable disease
metastasis
  • 73 views
  • 02 Jun, 2022
  • 183 locations
Pre Operative Trastuzumab in Operable Breast Cancer

each arm). The levels of circulating chromatin will also be estimated at the same time points as CTC for these 40 patients. Evaluation of the paraffin blocks for pTEN loss6-8 and p95ErbB2

tumor cells
trastuzumab
platelet count
progesterone
her1
  • 71 views
  • 14 May, 2022
  • 1 location
Prospective Evaluation of Hypofractionated Stereotactic RT Using CyberKnife for Patients With Prostate Cancer

The main purpose of study is to evaluate hypofractionated stereotactic radiotherapy (SBRT) using CyberKnife for Patients with low and intermediate risk of progression prostate cancer.

metastasis
adenocarcinoma of prostate
adenocarcinoma
  • 4 views
  • 23 Jan, 2021
  • 1 location