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Found 8 clinical trials
Brentuximab Vedotin in Early Diffuse Cutaneous Systemic Sclerosis

The purpose of this study is to assess feasibility, safety and preliminary efficacy of Brentuximab vedotin (Adcetris), a CD30-directed antibody-drug conjugate, in the treatment of active diffuse cutaneous systemic sclerosis (dcSSc).

  • 68 views
  • 22 Mar, 2022
  • 1 location
Belimumab and Rituximab Combination Therapy for the Treatment of Diffuse Cutaneous Systemic Sclerosis

This is a 52 week, single center, randomized, double-blind, placebo-controlled study. After patients maintain a stable dose of Mycophenolate Mofetil (MMF) for at least 1 month, they will be randomized to treatment with either Belimumab & Rituximab or placebo.Patients in both groups will be on background MMF for the entirety …

lupus
arthritis
MRSS
autoimmune disease
fibrosis
  • 29 views
  • 19 Apr, 2022
  • 1 location
A Study Evaluating the Efficacy and Safety of Baricitinib in Systemic Sclerosis

Systemic Sclerosis (Ssc) is a rare, systemic autoimmune disease characterized by skin fibrosis and vasculopathy. In addition to the skin, it is a heterogeneous disease that affects multiple organs, including the musculoskeletal, cardiac, pulmonary, and gastrointestinal systems. Patients may experience many symptoms such as pain, fatigue, dyspnea, impaired hand function, …

corticosteroids
autoimmune disease
MRSS
vascular disease
fibrosis
  • 0 views
  • 21 Apr, 2022
  • 1 location
Upfront Autologous HSCT Versus Immunosuppression in Early Diffuse Cutaneous Systemic Sclerosis

HSCT has been implemented in (inter)national treatment guidelines for diffuse cutaneous systemic sclerosis (dcSSc) and is offered in clinical care and reimbursed by national health insurance in several European countries. However, data and specific guidelines on the best timing of HSCT in the course of dcSSc are lacking. In particular, …

MRSS
g-csf
scleroderma
interstitial lung disease
raynaud's syndrome
  • 0 views
  • 18 Dec, 2021
  • 5 locations
Study on the Treatment With Water-filtered Infrared-A (wIRA) Radiation in Patients With Morphea and Sclerotic Graft-versus-host Disease

This is a prospective, intra-individual comparative study to evaluate the effectiveness of local-water filtered infrared-A (wIRA) irradiation (applied by Hydrosun radiator 750 for radiation at the clinic, or Hydrosun 575home for home treatment) in patients with morphea or sclerotic GVHD (Graft-versus-host Disease). The purpose of the study is to determine …

  • 0 views
  • 21 Jul, 2021
  • 2 locations
Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis (SSc)

The purpose of this study is to determine whether a regimen of high-dose immunoablative therapy will demonstrate safety that is consistent or improved with other published regimens in SSc patients, while maintaining a treatment effect.

MRSS
ct scan
systemic sclerosis
prednisone
fibrosis
  • 200 views
  • 24 Mar, 2022
  • 2 locations
UVA-1 for Treatment of Skin Tightening and Improvement of Hand Function in Scleroderma

UVA-1 has been reported to be beneficial to skin changes in scleroderma in several case reports and a few small studies. (Jacobe 2020) Interpretation of these reports has been difficult based on the small numbers of subjects involved and the non-blinded non-randomized nature of the reports. In a single controlled …

  • 0 views
  • 15 May, 2021
  • 1 location
Validation of the Risk Stratification Score in Idiopathic Pulmonary Fibrosis

Idiopathic pulmonary fibrosis (IPF) is characterized by a poor prognosis, with a progressive decline in lung function and a considerable variability in the disease's natural history. Besides lung transplantation (LTx), the only available treatments are anti-fibrosing drugs, which have shown to slower the disease course. Therefore, predicting the prognosis is …

scarring
idiopathic pulmonary fibrosis
pulmonary function test
dyspnea
emphysema
  • 138 views
  • 25 Nov, 2021
  • 2 locations