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Found 3098 clinical trials
Impact of Elastin Mediated Vascular Stiffness on End Organs

Background People with Williams Syndrome (WS) and supravalvular aortic stenosis (SVAS) have less elasticity in their blood vessels. This is called blood vessel stiffness. Blood vessels may have focal narrowings called stenoses or may just be globally more narrow. Objectives Researchers want to see how blood vessel differences in people …

supravalvular aortic stenosis
Accepts healthy volunteers
  • 16 Jun, 2022
  • 1 location
Observational Study of Factors Predicting Therapeutic Effects and Clinical Prognosis After HAIC for Locally Advanced HCC

Prospective single arm, single center observational study to evaluate factors which were easily available from preoperative examination for predicting therapeutic effects and clinical prognosis of hepatic artery infusion chemotherapy (HAIC) for hepatocellular carcinoma. There factors are collected in preoperative routine blood examination, preoperative radiological imaging and pathological examination. Patients which …

platelet count
pet scan
measurable disease
neutrophil count
  • 15 Jun, 2022
  • 1 location
Effect of Chronic Inflammation on Myocardial Perfusion and Function

Background Heart failure (HF) is a public health burden. Studies have shown a link between inflammation, myocardial dysfunction, and HF. Researchers want to use psoriasis as a disease model of chronic inflammation to further study the link between inflammation and myocardial dysfunction. Objective To learn if chronic inflammation affects the …

pet/ct scan
Accepts healthy volunteers
heart failure
  • 20 Jun, 2022
  • 1 location
Diagnosis of Alzheimer's Disease Using Event Related Potentials

This study evaluates the use of an EEG device using Event Related Potentials to help diagnose Alzheimer's Disease in the outpatient clinical setting.

memory impairment
memory loss
alzheimer's disease
  • 23 Feb, 2022
  • 1 location
The Dutch Parkinson and Cognition Study (DUPARC)

Parkinson Disease (PD) is a heterogeneous, progressive neurodegenerative disorder which is characterized by a variety of motor and non-motor symptoms. The DUPARC study is a single-centre longitudinal cohort study aimed at deeply phenotyping newly diagnosed PD patients. The main aim is to investigate the relationship between cognitive impairment and both …

Accepts healthy volunteers
neurodegenerative disorders
motor symptoms
cognitive impairment
  • 19 Feb, 2022
  • 1 location
The GBA Multimodal Study in Parkinson's Disease

This study plans to analyze the molecular and clinical mechanisms of the relationship between the GBA mutations and Parkinson's disease. This will be assessed through the use of advanced neuroimaging techniques called PET (positron emission tomography) to study the accumulation of the tau protein and the dysfunction of acetylcholine and …

positron emission tomography
gba gene
parkinson's disease
  • 25 Jan, 2022
  • 3 locations
Structural Stability of Carotid Plaque and Symptomatology

The purpose of the research is to understand structural plaque abnormalities that make a carotid plaque unstable and brake off (embolize) which would help to predict and treat individuals who are likely to suffer not only classic episodic major strokes but also cognitive impairment.

  • 11 Nov, 2021
  • 1 location
Validation of a Standardized Tool for Evaluation Function of Patients With TMD

Temporo-Mandibular Disorders (TMD) are the reason for consultation on more common in maxillofacial. However, there is no consensus on their care. For a long time, Rehabilitative management of the TMD was content to treat only the symptoms. No validated score does not allow to evaluate globally the malfunctions at the …

  • 22 Dec, 2021
  • 2 locations
Evaluation of Macroscopic Muscle Growth in Infants and Young Children With Spastic Cerebral Palsy (3D-MMAP)

A mixed longitudinal design study will be carried out to explore the onset and time course of morphological muscle changes on a macroscopic level in children with spastic cerebral palsy (SCP). Therefore, this project aims to (1) describe the macroscopic morphological muscle changes with increasing age and (2) evaluate the …

Accepts healthy volunteers
spastic cerebral palsy
brain lesion
  • 24 Mar, 2022
  • 1 location
Preparing for Prevention of Huntington's Disease (PREVENT-HD) (PREVENT-HD)

This is a prospective investigation which aims to address key challenges to the design of clinical trials to prevent the onset of Huntington's disease (HD). The project will provide necessary psychometric data for clinical outcome assessments (COAs) and biomarkers (BMs) in the cerebral spinal fluid (CSF) to address questions of …

Accepts healthy volunteers
cognitive assessment
genetic test
  • 27 Apr, 2022
  • 1 location