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Found 2992 clinical trials
Featured trial
Athlete Brain Health and Aging Study

The Athlete Brain Health and Aging Study is currently conducting research on former D1 collegiate athletes and former NFL players above the age of 30. Participation in the study will assist with our understanding of the impact of concussion, sub-concussive head injury, and sport participation on men’s health and well-being. …

Accepts healthy volunteers
Online studies
  • 35 views
  • 18 Nov, 2022
  • 1 location
  • Online study
Featured trial
Primary Progressive Multiple Sclerosis (PPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (PERSEUS)

> Secondary Objectives: To evaluate efficacy of SAR442168 compared to placebo on clinical endpoints, magnetic resonance imaging (MRI) lesions, cognitive performance, physical function, and quality

disease or disorder
oligoclonal bands
  • 110 views
  • 09 Nov, 2022
  • 11 locations
Featured trial
Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis

. The effect of the treatment will be checked by medical assessments, blood tests, Magnetic Resonance Imaging (MRI), bone marrow tests, checking for side effects, and completing questionnaires.

  • 380 views
  • 23 Oct, 2022
  • 150 locations
Featured trial
Preventing Alzheimer's With Cognitive Training (PACT)

Dementia is the most expensive medical condition in the US and increases in prevalence with age. More than 5 million Americans have Alzheimer's disease, the most common form of dementia. Mild cognitive impairment is a transitional stage between normal cognitive aging and Alzheimer's disease or another type of dementia, and …

cognitive stimulation
cognitive impairment
dementia
mild cognitive impairment
Accepts healthy volunteers
  • 1 views
  • 28 Oct, 2022
  • 5 locations
Featured trial
Randomized, Open Label Phase 3 Study of SAR408701 Versus Docetaxel in Previously Treated Metastatic Non- Squamous Non-Small Cell Lung Cancer Patients With CEACAM5 Positive Tumors (CARMEN-LC03)  

Primary Objectives: Study is designed with two primary endpoints that will be analyzed on randomized participants at the time of the cutoff date for each given analysis (progression free survival [PFS] and overall survival [OS]). Study success is defined either on PFS or OS The primary objective is to determine …

  • 132 views
  • 17 Nov, 2022
  • 5 locations
Featured trial
Cognitive Fitness for Depression in Older Adults

antidepressants. The investigators are also interested in whether participating in the treatment will result in changes to brain activity measured with magnetic resonance imaging (MRI).

  • 85 views
  • 22 Jan, 2022
  • 1 location
Featured trial
Network-targeted Theta-burst Stimulation for Episodic Memory Improvement in Mild Cognitive Impairment

The purpose of this study is to see if stimulation of the brain can improve memory. The investigators will use a device called Transcranial Magnetic Stimulation that can stimulate and activate a specific part of the brain that is important for memory. The study will enroll subjects aged 55-100 with …

  • 1 views
  • 04 Nov, 2022
  • 1 location
Featured trial
Valacyclovir for Mild Cognitive Impairment (VALMCI)

Anti-viral treatment in Mild Cognitive Impairment (MCI) is a Phase II, placebo-controlled, 52-week trial using oral valacyclovir 4 g/day in 50 HSV seropositive, AD biomarker-positive, amnestic mild cognitive impairment (MCI) patients (eMCI and lMCI). The trial will directly address the long-standing viral etiology hypothesis of Alzheimer's disease (AD) which posits …

  • 47 views
  • 08 Sep, 2022
  • 1 location
Featured trial
Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma(CLL/SLL), Lymphoplasmacytic Lymphoma(LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma(SMZL)

MRI scans. Some of these tests may be required to monitor CLL/SLL, LPL/WM, and SMZL patients. Other tests, such as bone marrow biopsy and aspiration, lymph node biopsy, may not be clinically indicated

marginal zone lymphoma
lymphoma
lymphocytosis
chronic lymphocytic leukemia
lymphadenopathy
  • 115 views
  • 15 Apr, 2019
  • 1 location
Featured trial
Inflammatory Characterization of Known or Possible Cardiovascular Diseases

PET/MRI). The procedures are similar to the FDG PET/CT scan. These other scans will last about 30 minutes total. Some participants will also have a CT scan of their heart. A substance will be

heart disease
diabetes
fats
  • 167 views
  • 23 Nov, 2020
  • 1 location