Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 141 clinical trials
Clinical and Genomic Registry of Myelodysplastic Syndrome (MDS) and Secondary Acute Myeloid Leukaemia (AML) in Asia

Myelodysplastic syndrome (MDS) is a group of clonal haematopoietic stem cell disorders characterized by ineffective haematopoiesis leading to cytopenia, with a significant risk of progression to acute myeloid leukaemia (AML). Progression to AML and resistance to hypomethylating agents (HMA) are important unmet clinical needs. The pathophysiology of MDS and its …

myeloproliferative disorder
chronic myelomonocytic leukemia
leukemia
cytopenia
myeloid leukemia
  • 0 views
  • 22 Oct, 2022
  • 1 location
Ontario-wide Cancer TArgeted Nucleic Acid Evaluation (OCTANE)

Substantial progress has been made in the treatment of cancer through the use of targeted therapies, but what works for one patient might not work for another patient. Certain drugs are now being developed that target specific molecules in the body that are believed to be part of the disease. …

cancer
systemic therapy
solid tumor
advanced solid tumor
formalin-fixed paraffin-embedded
  • 173 views
  • 10 Oct, 2022
  • 2 locations
Clinical Application of Genetic Sequencing of Early Gastric Cancer and Gastric Adenoma Patients

Because advanced gastric cancer shows poor prognosis, it is important to detect early gastric cancer or precancerous gastric adenoma patients who have a cure rate of 95% or more. Moreover, a large part of early gastric cancer can be completely resected by endoscopic resection, thus ensuring a very high quality …

  • 0 views
  • 28 Jan, 2021
  • 1 location
Circulating Tumor DNA Analysis to Optimize Treatment for Patients With Colorectal Cancer (IMPROVE)

The overall objective of these studies are to confirm that ctDNA detected in plasma after intended curative treatment for CRC can be applied in clinical practice as a marker of subclinical residual disease and risk of recurrence.

rectal carcinoma
  • 18 views
  • 10 Jul, 2022
  • 10 locations
RW Efficacy of Sotorasib in KRAS G12C-mutated Metastatic NSCLC (LungKG12Ci)

The purpose of the IFCT2102 Lung KG12Ci study is to closely monitor cohort ATU applications in order to collect retrospectively, as soon as possible after inclusion and under real-life conditions, the efficacy data on sotorasib (AMG 510) as well as the demographic and molecular characteristics of patients.

KRAS
liquid biopsy
  • 0 views
  • 04 Oct, 2022
  • 3 locations
A Retrospective Study: Evaluation of the Efficacy of Immunotherapy With Rare Mutations in Non-small Cell Lung Cancer

In advanced non-small cell lung cancer, there will be some rare mutations, such as ALK, KRAS, etc. The efficacy of these immunotherapies on these different rare mutations has not been reported

KRAS
lung carcinoma
BRAF
RET
erbb2
  • 0 views
  • 12 Mar, 2022
  • 1 location
Liquid Biopsy for ctDNA in Peritoneal Lavage and Blood in Pancreatic Cancer (LIPAC)

resection in Cy+ patients. KRAS mutations have been detected in circulating tumor DNA (ctDNA) in the blood (liquid biopsies) from patients with metastatic PC, and ctDNA is considered a marker of poor

pdac
KRAS
pancreatic resection
cancer chemotherapy
tumor cells
  • 0 views
  • 16 Jun, 2022
  • 1 location
Rare Subtypes of Gastrointestinal Cancers

A single-arm prospective observational translational study of biomarkers in patients receiving targeted treatment for rare subtypes of cancer of the Gastrointestinal Tract.

BRAF
cancer
  • 0 views
  • 22 Mar, 2022
  • 1 location
Circulating Tumor DNA as Marker for Response to Antineoplastic Treatment of Metastatic Cancer (FLUIDO)

Early monitoring of antineoplastic treatment benefit is a central medical need. Radiologic assessment for documentation of response is done after several months of treatment usually. This implies that patients not responding are exposed to unnecessary toxicity. According to several reports showing the correlation of the amount of circulating tumour DNA …

  • 0 views
  • 18 Mar, 2021
  • 1 location
Next Generation Sequencing (NGS) in Familial Acute Myeloid Leukemia and Myelodisplastic Syndromes

The aim of this study is to look for predisposing mutations in patients and relatives affected by AML and MDS with familial history of myeloid or, less frequently, lymphoid malignancies. Taking advantage of a next generation sequencing (NGS) platform, screening for known and unknown mutations potentially associated with the disease …

thrombocytopenia
myeloid leukemia
cancer
acute leukemia
  • 3 views
  • 01 May, 2022
  • 1 location