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Found 330 clinical trials
A Pivotal, Multicenter, Blinded, Sham Procedure-Controlled Trial of Renal Denervation by the Peregrine System™ Kit, in Subjects With Hypertension

The TARGET BP I Trial is a randomized, blinded, multi-center, international, sham-procedure controlled trial, comparing renal denervation performed with the Peregrine System Kit in the treatment

  • 10 Aug, 2020
  • 1 location
Comparative evaluation of the performance and safety of A-CP HA Kit, for the preparation of a combination of platelet-rich plasma and hyaluronic acid, versus hyaluronic acid alone and placebo in patients with knee osteoarthritis

The purpose of this study is to assess the performance and safety of a combination of hyaluronic (HA) and platelet-rich plasma (PRP) in knee injection treatment for use in relieving symptoms in patietns with knee pain. To qualify you must be between ages 50 and 80, have Grade 2 or …

knee pain
hyaluronic acid
  • 11 Jun, 2020
  • 1 location
A Randomized Phase 3 Study of Sitravatinib in Combination with Nivolumab Versus Docetaxel in Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer with Disease Progression On or After Platinum-Based Chemotherapy and Checkpoint Inhibitor Therapy (SAPPHIRE)

This is an open-label, randomized (1:1), multicenter, Phase 3 clinical trial evaluating the safety and efficacy of nivolumab in combination with investigational agent sitravatinib compared to docetaxel in patients with advanced non-squamous NSCLC who have previously experienced radiographic disease progression on or after treatment with platinum-based chemotherapy in combination with …

cancer chemotherapy
advanced non-squamous non-small cell lung cancer
lung cancer
lung carcinoma
  • 23 Apr, 2021
  • 161 locations
A Phase 1/1b Study of Sitravatinib in Combination with Nivolumab and Ipilimumab in Patients with Advanced or Metastatic Clear-Cell Renal Cell Carcinoma or Other Solid Malignancies

related RTKs including the TAM family (Tyro3/Axl/MERTK), VEGFR2, KIT, and MET. NIVO/IPI are monoclonal antibodies (mAbs) that inhibit the immune checkpoint proteins programmed death receptor-1 (PD-1

systemic therapy
monoclonal antibodies
  • 15 Sep, 2020
  • 1 location
Phase 2 Study of Glesatinib, Sitravatinib or Mocetinostat in Combination With Nivolumab in Non-Small Cell Lung Cancer

Phase 2 Study of Glesatinib, Sitravatinib or Mocetinostat in Combination With Nivolumab in Non-Small Cell Lung Cancer

  • 08 Nov, 2020
  • 2 locations
The TISA Trial - Senegal

This study evaluates the addition of a simple, scalable "WASH kit", including household water treatment products, a safe water storage container, and hygiene promotion, to the standard national

  • 27 Jan, 2021
  • 1 location
GENetic Education Risk Assessment and TEsting Study

education. Participants may elect to undergo genetic testing as part of the study and will be asked to provide a saliva sample via a saliva-testing kit. The genetic testing done in this study is FDA

  • 24 Jan, 2021
Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis

Kit (Zeesan Company, Xiamen). Participants with slow or intermediate acetylators will be administered with standard chemotherapy. For participants with rapid acetylators, patients were stratified at

  • 05 Feb, 2021
  • 4 locations
Implementation Research of Kangaroo Mother Care in Rural Pakistan.

Pakistan has a high neonatal mortality rate (55/1000 live birth)(1) and each year more than 200,000 newborns die. In rural Pakistan, more than 50% deliveries occur at home and majority by unskilled birth attendants(2). The country has a high proportion of preterm births and according to unpublished data it ranges …

  • 24 Jan, 2021
  • 2 locations
Point of Care Tests for Syphilis and HIV

This study will evaluate the performance of two point-of-care dual syphilis and HIV tests [Multiplo TP/HIV test (MedMira Inc, Halifax, Nova Scotia) and the INSTI Multiplex HIV-1/HIV-2/Syphilis Antibody Test (bioLytical Laboratories Inc., Richmond, BC)]. In addition to standard syphilis and HIV testing, point-of care testing (POCT) will be performed on …

antibody test
hiv test
hiv insti
  • 25 Jan, 2021
  • 1 location