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Found 44 clinical trials
A Study of Switching to RPV Plus Other ARVs in HIV-1-infected Children (Aged 2 to <12 Years) Who Are Virologically Suppressed

The purpose of this study is to evaluate the steady state pharmacokinetics (PK) of rilpivirine (RPV) and determine the appropriate dose of RPV in combination with other antiretrovirals (ARVs) in participants aged greater than or equal to 2 to less than 12 years and to evaluate the safety and tolerability …

HIV Vaccine
abacavir
dolutegravir
antiretroviral agents
immunodeficiency
  • 53 views
  • 02 Dec, 2020
  • 19 locations
Translating the ABCS Into HIV Care

The overall objective of this project is to develop and rigorously test implementation strategies to address the gap in scientific knowledge of lower use of evidence-based interventions commonly referred to as the ABCS (aspirin, blood pressure control, cholesterol control, and smoking cessation)which contributes to the growing CVD morbidity and mortality …

  • 0 views
  • 01 Dec, 2020
  • 1 location
Evaluating HITSystem 2.1 to Improve Viral Suppression in Kenya

The goal of this project is to rigorously evaluate the efficacy of HIV Infant Tracking System 2.1 (HITSystem, an eHealth intervention that uses short message service (SMS) texts to patients and algorithm-driven electronic alerts for providers) to increase retention in guideline-adherent prevention of mother-to-child transmission of HIV services (PMTCT) and …

  • 0 views
  • 12 Nov, 2020
  • 3 locations
10E8.4/iMab Bispecific Antibody in HIV-uninfected and HIV-infected Adults

of HIV infection because they can protect macaques from infection, and the presence of anti-HIV antibodies was the only positive correlate of protection in an HIV vaccine efficacy trial (RV144 trial

  • 0 views
  • 16 Mar, 2020
  • 1 location
TB Screening Improves Preventive Therapy Uptake

HIV-infected people have an increased risk of developing active tuberculosis (TB). To reduce the burden of TB among people living with HIV (PLHIV), the World Health Organization (WHO) recommends systematic TB screening followed by 1) confirmatory TB testing for all those who screen positive and 2) TB preventive therapy (TPT) …

  • 0 views
  • 24 Dec, 2020
  • 1 location
Leveraging the HIV Platform for Hypertension Control in Uganda (INTEGRATED HIV/HTN) STUDY

The INTEGRATED HIV/HTN is a hybrid type-1 effectiveness/implementation cluster randomised trial evaluating the introduction of a multi-component integrated HIV/HTN care model intervention, randomised to 13 districts in the intervention arm compared to 13 districts in the control. Selected health facilities within the 13 intervention districts will receive the intervention while …

  • 0 views
  • 07 Dec, 2020
  • 1 location
Amsterdam UMC Clinical Trial With a Native-like HIV-1 Envelope Vaccine

ACTHIVE-001 is a randomised, open-label, uncontrolled phase 1 clinical trial to determine the safety profile of the native-like HIV-1 envelope vaccine, ConM SOSIP.v7, adjuvanted with monophosphoryl lipid A (MPLA) liposomes. The study will furthermore determine the extent to which the vaccine influences the breadth of viruses neutralised by induced antibodies …

  • 4 views
  • 17 Jan, 2021
  • 1 location
EPIC-P Intervention

This non-randomized, open-label study will address the following research aims in People who inject drugs (PWID): To assess the feasibility and acceptability of the Expanding PrEP Implementation in Communities of PWID (EPIC-P) intervention among high-risk PWID. To determine the preliminary efficacy of the EPIC-P intervention in terms of increasing adherence …

AIDS prevention
AIDS
drug use
injection drug
  • 0 views
  • 14 Jan, 2021
  • 1 location
CD4 CAR+ ZFN-modified T Cells in HIV Therapy

This research study is being carried out to study a new way to possibly treat HIV. As part of this study, doctors will take some of your own white blood cells, called T-cells, and modify them so that they can identify and target your HIV cells. The purpose of the …

antiretroviral therapy
hiv-1 rna measurement
hepatitis
hiv-1 infection
haart
  • 27 views
  • 27 Dec, 2020
  • 1 location
Effects of Biktarvy on CFR in Stable HIV Patients

Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) is a single pill regimen that was approved by the FDA in February 2018 for treatment of HIV. The marketed name of the drug is Biktarvy. In two phase 3 comparative clinical trials, including one with ABC/3TC/DTG, it was found to be non-inferior to dolutegravir-containing regimens in …

HIV Vaccine
hiv test
abacavir
hypertension
dolutegravir
  • 0 views
  • 14 Jan, 2021
  • 2 locations