Found 154 clinical trials
Safety and Immunogenicity of Candidate HIV Vaccines Given Sequentially
The primary object of the study is to assess the safety profile of candidate vaccines ChAdOx1.HTI and MVA.HTI administered sequentially in healthy HIV-1/2 negative adult volunteers. In addition, the study will assess the immune responses generated of the candidate vaccines ChAdOx1.HTI and MVA.HTI administered sequentially in healthy HIV-1/2 negative adult …
- 0 views
- 16 Aug, 2021
- 1 location
A Study of Switching to RPV Plus Other ARVs in HIV-1-infected Children (Aged 2 to <12 Years) Who Are Virologically Suppressed
The purpose of this study is to evaluate the steady state pharmacokinetics (PK) of rilpivirine (RPV) and determine the appropriate dose of RPV in combination with other antiretrovirals (ARVs) in participants aged greater than or equal to 2 to less than 12 years and to evaluate the safety and tolerability …
- 53 views
- 21 Apr, 2021
- 19 locations
Strategic Antiretroviral Therapy and HIV Testing for Youth in Rural Africa
The goal of this study is to evaluate the effect of a combination intervention on long-term HIV viral load (VL) suppression among HIV-infected adolescents and young adults 15-24 years of age. The study will take place in 28 rural HIV clinics in western Kenya and southwest Uganda. Clinics will be …
- 0 views
- 26 Jun, 2021
- 2 locations
Optimizing HIV Virologic Outcomes for Pregnant Women in Uganda
The ENHANCED -SPS study is a before and after cluster randomized trial that will be conducted in 14 public health facilities providing HIV care in Southwestern Uganda. The study will evaluate the effectiveness of a multi-component intervention package that targets barriers to achieving optimal viral suppression among pregnant and postpartum …
- 0 views
- 23 Jan, 2021
- 1 location
Promoting Reductions in Intersectional StigMa (PRISM) - GHANA
HIV prevalence among men with have sex with men (MSM) in Ghana is at least eight times higher than that of the general population (2%). MSM in Ghana face high levels of stigma due to HIV status (actual or perceived), same-sex behavior, and gender non-conformity. These stigmas are documented barriers …
- 0 views
- 14 Jun, 2021
- 1 location
Evaluation of Web-based Interventions to Support People Living With HIV in the Adoption of Health Behaviors
The purpose of this study is to evaluate the efficacy of a web-based tailored intervention to support persons living with HIV (PLHIV) manage the demands inherent to their health condition, particularly as regards to the adoption of health behaviours such as being physically active, following a healthy diet and quitting …
- 6 views
- 13 Aug, 2021
- 3 locations
Pediatric HIV Disclosure Benefits Study (PhD-BS) - Sankofa 2
The purpose of this study is to conduct a pragmatic, stepped wedge cluster randomized trial in 12 HIV pediatric clinics in Ghana to determine effectiveness, health benefits, cost and implementation to inform scale-up and sustainability of pediatric disclosure.
- 0 views
- 21 Sep, 2021
- 1 location
The Welcome Incoming Neighbor (WIN) Community Trial
Migration is common in rural Africa: in-migrants have higher HIV incidence and prevalence than community residents, but underutilize combined HIV prevention and care services, including voluntary medical male circumcision and antiretroviral therapy, increasing the risks of HIV acquisition and onward transmission. Uptake of combined HIV prevention (CHP) is critical in …
- 0 views
- 09 Sep, 2021
- 1 location
Increasing MSM in the Continuum of Care in Kazakhstan
This study addresses the disproportionate representation of men who have sex with men (MSM) in the human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) pandemic in Kazakhstan, a country that has seen some of the largest growth in new HIV infections since the turn of the century. Using a stepped wedge …
- 46 views
- 26 Mar, 2021
- 2 locations
Translating the ABCS Into HIV Care
The overall objective of this project is to develop and rigorously test implementation strategies to address the gap in scientific knowledge of lower use of evidence-based interventions commonly referred to as the ABCS (aspirin, blood pressure control, cholesterol control, and smoking cessation)which contributes to the growing CVD morbidity and mortality …
- 0 views
- 27 Jan, 2021
- 1 location