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Found 11 clinical trials
Phase 2 Study of LUM-201 in Children With Growth Hormone Deficiency (OraGrowtH210 Trial) (OraGrowtH210)

This is a multi-national trial. The goals of the trial are to study LUM-201 as a possible treatment for Pediatric Growth Hormone Deficiency (PGHD) and investigate a predictive enrichment marker (PEM) strategy to select subjects likely to respond to therapy with LUM-201.

  • 3 views
  • 17 Jun, 2022
  • 42 locations
A Trial to Compare the Efficacy and Safety of Once-weekly Lonapegsomatropin With Placebo and a Daily Somatropin Product in Adults With Growth Hormone Deficiency (foresiGHt)

A 38 week dosing trial of lonapegsomatropin, a long-acting growth hormone product, administered once-a-week versus placebo-control. A daily somatropin product arm is also included to assist clinical judgement on the trial results. Approximately 240 adults (males and females) with growth hormone deficiency will be included. Randomization will occur in a …

  • 6 views
  • 28 Apr, 2022
  • 39 locations
Albright Hereditary Osteodystrophy: Natural History, Growth, and Cognitive/Behavioral Assessments

We, the researchers, are following the natural history of Albright hereditary osteodystrophy. We have found that growth hormone deficiency is very common in patients with pseudohypoparathyroidism type 1a, which falls under the broader condition termed Albright hereditary osteodystrophy. Patients with pseudohypoparathyroidism type 1a typically are short and obese. Some of …

  • 110 views
  • 23 Jan, 2022
  • 1 location
Safety and Efficacy of Y-shape Pegylated Somatropin in Growth Hormone Deficiency Children

This is a multicenter, randomized, open-labeled, positive controlled phase 2&3 combined study to evaluate the safety and efficacy of weekly Y-shape pegylated somatropin, compared to daily somatropin (Norditropin®), in prepubertal, treatment-naive children with growth hormone deficiency.

somatomedin c
short stature
stimulation test
somatropin
  • 10 views
  • 22 Mar, 2022
  • 1 location
PK and PD Study of LUM-201 in Children With Idiopathic Growth Hormone Deficiency. (OraGrowtH212)

The goals of this single site trial are to study the pharmacokinetics (PK) and pharmacodynamics of LUM-201 and effects of LUM-201 administration on growth hormone release over time in children with idiopathic pediatric growth hormone deficiency (PGHD).

  • 0 views
  • 23 Jul, 2022
Growth Hormone Replacement Therapy for Retried Professional Football Players

This is a randomized, double-blind, placebo-controlled, parallel-group trial with an open-label extension to evaluate the efficacy of growth hormone (GH) on cognitive functions of retired professional football players with growth hormone deficiency (GHD).

growth hormone
  • 8 views
  • 06 Aug, 2021
  • 1 location
Chromosome 18 Clinical Research Center (Chromosome18)

Our vision, that of the researchers at the University of Texas Health Science Center at San Antonio, is that every person with a chromosome 18 abnormality will have an autonomous and healthy life. Our mission is to provide families affected by chromosome 18 abnormalities with comprehensive medical and educational information. …

Accepts healthy volunteers
  • 9 views
  • 23 Jan, 2022
  • 2 locations
Long-term Safety and Effectiveness of Growtropin -II Treatment in Children With Short Stature

This study evaluates long-term safety and effectiveness of Growtropin-II treatment in children with short stature.

  • 2 views
  • 25 Mar, 2021
  • 1 location
Long-term Safety and Effectiveness of Growth Hormone With GHD, TS, CRF, SGA , ISS and PWS in Children (LGS)

The purpose of this study is to evaluate the long-term safety and effectiveness of growth hormone (Eutropin Inj./Eutropin plus Inj.) treatment with GHD (Growth Hormone Deficiency), TS (Turner Syndrome),CRF (Chronic Renal Failure), SGA (Small for Gestational Age), and ISS (Idiopathic Short Stature).

short stature
renal failure
turner syndrome
hormone deficiency
deficiency
  • 464 views
  • 30 Jan, 2022
  • 1 location
Assessment of Adherence Quality of Life Clinical Response and Safety of Daily and Long-Acting Growth Hormone Therapy

The purpose of the study is to compare quality of life, adherence, insulin resistance, body composition and efficacy of long-acting growth hormone (LAGH) to daily growth hormone (DGH) in children with growth hormone deficiency (GHD). These objectives will be evaluated every 6 months for subjects prior to switch from DGH …

  • 0 views
  • 16 Oct, 2021
  • 1 location