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Found 36 clinical trials
A Study of Standard and Individualized Prophylactic Treatment With Advate in Men and Boys With Severe Hemophilia A

The main aim of this study is to learn about changes in the lowest blood levels of Factor VIII in men and boys when upgraded from standard prophylaxis with Advate to individualized prophylaxis

  • 07 Oct, 2021
  • 10 locations
Von Willebrand Factor in Pregnancy (VIP) Study

In pregnant women with von Willebrand disease (VWD) who by the third trimester do not have von Willebrand factor (VWF) or factor VIII (FVIII) levels greater than 50-100%, specific guidance is

von willebrand factor
antihemophilic factor
Factor VIII
tranexamic acid
  • 04 Feb, 2021
  • 3 locations
Clinical and Health-related Outcome of rFVIIIFc Prophylaxis

(Haemophilia A) or rather FIX (Haemophilia B) two to three times weekly. With the development of recombinant factor VIII Fc fusion protein (rFVIIIFc) the conventional routine prophylaxis regime is complemented

  • 16 May, 2021
  • 2 locations
Influence of Cardiac Implantable Electronic Devices on the Hemostatic System

The hemostasis system is one of the many biological systems of the human body, designed to preserve the liquid state of blood and prevent its loss during vascular injuries. The ideal balance between its coagulant and anticoagulant components never occurs. In various diseases and pathological conditions, the balance of the …

duplex ultrasound
atrial fibrillation
pulmonary embolism
  • 01 Oct, 2021
  • 1 location
ATHN 11: Liver Transplantation Outcomes Study (HOT)

This study is designed as a multi-center, observational cohort study of participants with hemophilia A and B who have and have not undergone liver transplantation. Participants will be asked to complete health related quality of life questionnaires and provide medical history.

liver transplant
  • 21 Mar, 2022
  • 15 locations
A Survey on the Success of Inhibitor Elimination Using Individualized Concentrate Selection and Controlled ITI

This research program is initiated to evaluate and document data on the success of ITI in 300 haemophilia A patients with newly developed or already existing FVIII-inhibitors (also patients who might potentially have failed in earlier ITIs), which will be treated with ITI - preferably high-dose based on individualized product …

antihemophilic factor
thrombin generation test
  • 16 Sep, 2021
  • 1 location