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Found 82 clinical trials
Speeding the Weaning up: Aggressive Screening Criteria and Higher Minimal Ventilatory Settings. (SPEED-UP)

: This is a multicenter randomized open trial with 4 arms. Screening with PaO2/FiO2 > 180 and PEEP ≤ 10cm H2O; SBT with "HIGH minimal ventilator settings" (PS 8 + PEEP 5 cm H2O).

  • 0 views
  • 04 Oct, 2022
  • 1 location
PET - PEEP by EIT for Acute Respiratory Distress Syndrome Trial

lower PEEP/FiO2 table-oriented PEEP strategy.

acute respiratory distress
FIO2
positive end expiratory pressure
  • 0 views
  • 15 May, 2022
  • 1 location
Effect of EIT-guided PEEP Titration on the Prognosis of Patients With Moderate to Severe ARDS

. This article compared the effect of PEEP titrated guided by EIT with fraction of inspired oxygen (FiO2)-PEEP table on the clinical outcomes.

  • 0 views
  • 04 Oct, 2022
  • 1 location
Nurses-driven, Capnography-guided Protocol Weaning From the Mechanical Ventilation at Bedside: A Feasibility Study (NURSES-WEAN)

following criteria are present: PEEP ≤ 8 cmH2O, PaO2/FiO2 ratio ≥150 (mmHg) or SaO2 ≥ 90% with FiO2 ≤ 0.5. The final criterion for study entry is successful completion of a 30-min spontaneous breathing test

  • 0 views
  • 17 Jun, 2022
  • 1 location
Flow Rates of High-flow Nasal Cannula and Extubation Outcome

This is a single-center, open-label, randomized controlled trial to evaluate the effect of high-flow nasal cannula with a flow rate of 60 L/min versus 40 L/min after planned extubationon on a composite outcome of reintubation and use of NIV.

  • 0 views
  • 18 Jun, 2022
  • 1 location
Effect of AIRVO Heated Humidification in Bronchiectasis (AIRVO-BX)

The aim of the study is to investigate whether long-term heated humidification therapy (AIRVO) administrated for 1 year over-night on top of standard therapy can reduce the number of exacerbations in adults with non-cystic fibrosis bronchiectasis.

  • 46 views
  • 04 Oct, 2022
  • 14 locations
The Impact of the Vasodilator, Sildenafil, on the Pulmonary Circulation During Exercise in Healthy Trained and Untrained Humans

There is emerging evidence suggesting that the pulmonary vasculature and right heart may play a role in the limitation of exercise capacity in healthy individuals. It is well established that aerobic training improves cardiovascular function. While the pulmonary system is integral to the function of the cardiopulmonary system, it has …

Accepts healthy volunteers
  • 0 views
  • 15 Oct, 2022
  • 1 location
Inhibition of Bradykinin in COVID-19 Infection With Icatibant (ICASARS)

There is excess accumulation of bradykinin during symptomatic SARS CoV-2 lung infection. Bradykinin causes oedema in the lung, with reduced oxygen. It also causes vasodilation, hypotension and cytokine release.

  • 0 views
  • 19 Jun, 2022
  • 1 location
Trial of Maternal Oxygen for Fetal Left Heart Hypoplasia

The purpose of this study is to determine if maternal hyperoxygenation is an effective treatment for fetal left heart hypoplasia versus room air (placebo). This will be determined by measuring how well a baby's heart valves and their surrounding tissue are growing and functioning. In addition the investigators will examine …

  • 0 views
  • 08 Dec, 2021
  • 1 location
Perioperative Respiratory Care and Outcomes for Patients Undergoing High Risk Abdominal Surgery

major abdominal surgery. Patients will be recruited from low and middle income countries and randomly assigned to a trial treatment arms: a) pre-operative chlorhexidine mouthwash and 80-100% FiO2

  • 0 views
  • 27 Jan, 2021
  • 1 location