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Found 5 clinical trials
Olaparib in Treating Patients With Metastatic or Advanced Urothelial Cancer With DNA-Repair Defects

This phase II trial studies how well olaparib works in treating patients with urothelial cancer with deoxyribonucleic acid (DNA)-repair defects that has spread to other places in the body (advanced or metastatic) and usually cannot be cured or controlled with treatment. PARPs are proteins that help repair DNA mutations. PARP …

nivolumab
avelumab
measurable disease
metastasis
atezolizumab
  • 92 views
  • 26 Jul, 2021
  • 4 locations
Phase II Trial of Talazoparib in BRCA1/2 Wild-type HER2-negative Breast Cancer and Other Solid Tumors

The aim of this single-arm phase 2 clinical trial is to evaluate the anti-cancer activity of Talazoparib (also known as BMN 673) in patients with advanced breast cancer with specific genetic or tumor genomic alterations. Patients with either triple-negative or HER2-negative breast cancer are eligible.

BRCA1/2
BRCA2
progesterone receptor
CHEK2
metastasis
  • 5 views
  • 24 Jan, 2021
  • 1 location
Berzosertib and Irinotecan in Treating Patients With Progressive Metastatic or Unresectable TP53 Mutant Gastric or Gastroesophageal Junction Cancer

This phase II trial studies the how well berzosertib and irinotecan work in treating patients with gastric or gastroesophageal junction cancer that is growing, spreading or getting worse (progressive), has spread to other places in the body (metastatic), or cannot be removed by surgery (unresectable). Berzosertib may stop the growth …

  • 0 views
  • 22 Jul, 2021
  • 16 locations
Homologous Recombination Deficiency Status in Epithelial Ovarian Cancer

, CDK12, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCI, FANCL, MRE11A, NBN, PALB2, PPP2R2A, PTEN, RAD50, RAD51B, RAD51C, RAD51D, RAD54B, RAD54, MLH1, MSH2, MSH6, PMS2, EPCAM, STK11

FAM175A
fancl
ATR
RAD51D
BRCA1/2
  • 0 views
  • 23 Jan, 2021
  • 1 location
Men at High Genetic Risk for Prostate Cancer

Background Research studies have shown that genetic changes and family history may increase a man s risk for prostate cancer. Researchers want to follow the prostate health of men who have specific genetic changes associated with prostate cancer to help them learn more about which men are at higher risk …

blood test
cancer
MRI
testosterone
  • 65 views
  • 24 Jul, 2021
  • 1 location