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Found 80 clinical trials
Pancreas Registry and High Risk Registry

The purpose of this study is to establish a registry of patients with pancreatic diseases. Patients included in the registry may include those with: pancreatic cancer, precancerous lesions of the pancreas, inflammatory lesions of the pancreas, cystic lesions of the pancreas, and patients at high-risk of pancreatic cancer such as …

BRCA2
cancer
hnpcc
pdac
intraductal papillary mucinous neoplasms of the pancreas
  • 136 views
  • 08 Jun, 2022
  • 1 location
Precision-Based Genomics in Prostate Cancer

Background Prostate cancer is the most common cancer and the second leading cause of death in males in the United States. Researchers want to find additional gene mutations that may increase a man s risk for prostate cancer and may affect how aggressive the disease is. Objective To look at …

  • 0 views
  • 25 Jul, 2022
  • 1 location
The PROFILE Study: Germline Genetic Profiling: Correlation With Targeted Prostate Cancer Screening and Treatment (PROFILE)

Prostate cancer is now the commonest cancer in men in the Western world, with over 49,000 new cases diagnosed each year and a lifetime risk of 1 in 11 in the United Kingdom. Prostate cancer (PrCa) can run in some families and research studies have identified several genetic changes in …

prostate specific antigen
prostate cancer screening
Accepts healthy volunteers
  • 1 views
  • 25 Apr, 2022
  • 1 location
Pancreatic Cancer Genetics

The aim of this study is to determine the frequency of the three most common BReast CAncer gene 1 (BRCA1) and BReast CAncer gene 2 (BRCA2) genetic mutations that are commonly found in Ashkenazi

BRCA2
BRCA1
  • 0 views
  • 22 Aug, 2021
  • 1 location
The GENPET Study - An Imaging Study of FCH-PET-CT in Men With Prostate Cancer and a BRCA Gene Mutation. (GENPET)

The aim of the study is to determine if FCH-PET-CT imaging is superior to combined bone scan and MRI/CT of the abdomen & pelvis in detecting the increased incidence of metastasis (nodal/distant outside the pelvis) in men with prostatic carcinoma with germline BRCA mutations.

  • 0 views
  • 25 Apr, 2022
  • 1 location
Prostate Cancer Genetic Risk Evaluation and Screening Study

This study aims to define the natural history of men at high genetic risk for prostate cancer on the basis of specific germline genetic mutations or a positive family history and evaluate the utility of prostate MRI as a screening tool. The hypothesis is that this targeted population of men …

  • 0 views
  • 22 Dec, 2021
  • 1 location
Longitudinal Sample Collection to Investigate Adaptation and Evolution of Ovarian High-grade Serous Carcinoma (BriTROC-2)

In BriTROC-2, up to 250 women with a confirmed diagnosis of high-grade serous/high-grade endometrioid or carcinosarcoma will be eligible for full consent (Part 2) and registration to BriTROC-2 and will be followed prospectively until first relapse. Women with presumed newly-diagnosed high-grade serous carcinoma of the ovary, fallopian tube or peritoneum …

BRCA2
ovarian epithelial carcinoma
carcinoma
fallopian tube
carcinosarcoma
  • 0 views
  • 19 Sep, 2022
  • 4 locations
Cascade Testing in Families With Newly Diagnosed Hereditary Breast and Ovarian Cancer Syndrome

Identification of BRCA mutations in ovarian cancer patients may help guide cancer therapies, prognosis, post-operative screening, and other preventative treatments beyond the initial diagnosis. Likewise, genetic testing of ovarian cancer patients for these germline mutations provides invaluable information for families regarding cancer risk, genetic testing, and subsequently indication for risk-reducing …

Accepts healthy volunteers
  • 0 views
  • 02 May, 2022
  • 1 location
Evaluation of the Technical Feasibility of Testing Circulating Tumour DNA for Homologous Recombination Gene Variants in Metastatic Prostate Cancer. (PROMECI)

Evaluation of technical feasibility for Homologous Recombination (HR) genes variants research on circulating tumor DNA (ctDNA) from plasma and urine of patients with a metastatic prostate cancer.

  • 0 views
  • 19 Sep, 2022
  • 1 location
Preliminary Evaluation of Screening for Pancreatic Cancer in Patients With Inherited Genetic Risk

The study is a prospective, observational study evaluating the utility of endoscopic ultrasound or MRI for the identification of preneoplastic and neoplastic pancreatic lesions in patients at high risk for pancreatic cancer, specifically those with BRCA1/2, ATM, or PALB2 mutations.

BRCA2
pdac
ATM
BRCA1/2
palb2
  • 10 views
  • 15 Jun, 2022
  • 1 location