Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 80 clinical trials
Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations (ORCHID)

, BRCA1, BRCA2, PALB2, CHEK2, BRIP1, RAD51C, BARD1, CDK12, CHEK1, FANCL, PP2R2A, RAD51B, RAD51D, or RAD54L who have had prior treatment with at least one immune checkpoint inhibitor or anti-VEGF

palb2
measurable disease
CHEK1
serum pregnancy test
oophorectomy
  • 21 views
  • 09 Feb, 2022
  • 1 location
A Study of ZEN003694 and Talazoparib in Patients With Triple Negative Breast Cancer (TNBC)

This is a two-part open label, non-randomized, Phase 2, study of ZEN003694 in combination with Talazoparib in patients with TNBC without germline mutations of BRCA1 or BRCA2. Part 1 is a dose

measurable disease
BRCA1
triple negative breast cancer
breast cancer
estrogen
  • 0 views
  • 27 Jul, 2022
  • 10 locations
Olaparib In Metastatic Breast Cancer

with BRCA1 and BRCA2 to repair damaged DNA .This mutation may have been inherited from a parent, or may have developed only in the tumor. This study will also evaluate whether olaparib is

measurable disease
BRCA1
oophorectomy
breast cancer
denosumab
  • 220 views
  • 12 Jul, 2022
  • 18 locations
Veliparib and Dinaciclib in Treating Patients With Advanced Solid Tumors

This phase I trial studies the side effects and the best dose of veliparib and dinaciclib in treating patients with solid tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment. Veliparib and dinaciclib may stop the growth of tumor cells …

tumor cells
solid tumour
blood transfusion
neutrophil count
international normalized ratio
  • 6 views
  • 14 Jul, 2022
  • 1 location
Pilot Study of Single-port Robot-assisted Nipple-sparing Mastectomy

Nipple-sparing mastectomy (NSM) is indicated for breast cancer requiring total mastectomy and without nipple involvement by cancer. Robot-assisted mastectomy enables removal of the whole breast tissue with well-preserved breast skin envelope through a single longitudinal incision in the anterior axillary line at the nipple areolar level. The next-generation robot, da …

carcinoma
axillary lymph node dissection
BRCA1/2
BRCA1
cancer
  • 0 views
  • 11 Aug, 2022
  • 1 location
Prostate Screening Study Using MRI in BRCA Carriers

Men with a BRCA1 or BRCA2 mutation are at increased risk for early onset, aggressive prostate cancer compared to men in the general population. Standard of care screening for men with a

BRCA2
BRCA1
digital rectal examination
transrectal ultrasound
  • 11 views
  • 25 May, 2022
  • 1 location
Docetaxel, Carboplatin, and Rucaparib Camsylate in Treating Patients With Metastatic Castration Resistant Prostate Cancer With Homologous Recombination DNA Repair Deficiency

This phase II trial studies how well docetaxel with carboplatin followed by rucaparib camsylate works in treating patients with metastatic castration resistant prostate cancer (spread outside of prostate and resistant to testosterone suppression) with homologous recombination DNA repair deficiency. Chemotherapy drugs, such as docetaxel and carboplatin, work to stop the …

biomarker analysis
tumor cells
palb2
androgen
sipuleucel-t
  • 28 views
  • 30 Jun, 2022
  • 1 location
Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations

This phase II trial studies how well olaparib works in treating patients with biliary tract cancer that has spread to other places in the body (metastatic) and with aberrant DNA repair gene mutations. Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell …

tumor cells
palb2
measurable disease
hysterectomy
oophorectomy
  • 0 views
  • 29 May, 2022
  • 5 locations
Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects

This phase II trial studies how well niraparib, when given before surgery, works in treating patients with high risk prostate cancer that has not spread to other parts of the body (localized) and alterations in deoxyribonucleic acid (DNA) repair pathways. Niraparib may stop the growth of tumor cells by blocking …

tumor cells
palb2
prostatectomy
cancer
platelet count
  • 6 views
  • 21 Mar, 2022
  • 1 location
BrUOG 390: Neoadjuvant Treatment With Talazoparib

Ovarian cancer is the most fatal gynecologic cancer; in the US alone an estimated 22,000 women will be diagnosed in 2019, with over 13,000 dying of the disease. Approximately half of epithelial ovarian cancers (EOC) exhibit defective DNA repair through alterations in the homologous recombination (HR) pathway, with 14% accounted …

fallopian tube
measurable disease
BRCA1
breast cancer
adenocarcinoma
  • 0 views
  • 25 Jul, 2022
  • 2 locations