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Found 111 clinical trials
Prospective Cohort Study of Germline Variant Carriers With BRCA1 or BRCA2

To determine the incidence and risk factors in the development of ovarian, fallopian tube, and peritoneal cancers in Japanese women carrying Breast Cancer Susceptibility Gene (BRCA)1/2 variants.

BRCA2
BRCA1/2
BRCA1
breast cancer
cancer
  • 9 views
  • 08 Apr, 2021
  • 2 locations
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

Background A germline mutation is a change to a person s genes that is carried through their DNA. These mutations can be passed on from parents to their offspring. Germline mutations in a gene called BAP1 are linked to the development of mesothelioma and other cancers. Researchers want to follow …

thoracoscopy
cancer
Accepts healthy volunteers
BAP1
  • 0 views
  • 28 Oct, 2022
  • 1 location
Triple Negative Breast Cancer and Germline Hereditary Breast and Ovarian Cancer Mutation Carrier Registry (PROGECT)

PROGECT is a registry for patients with Triple Negative breast cancer (TNBC) or patients who have an identified germline mutations (such as a mutation on the BRCA1 or BRCA2 genes).

BRCA2
triple negative breast cancer
palb2
BRCA1
Accepts healthy volunteers
  • 22 views
  • 26 Apr, 2022
  • 13 locations
LobularCard Trial: Searching for Novel Germline Mutations in Lobular Breast Cancer Patients (LobularCard)

This is a cross-sectional and retrospective study of a cohort of patients with invasive lobular breast cancer (LBC) or in situ lobular neoplasia (LIN3). The main endpoint is the relative frequency of patients with a germline mutation using a recent panel including 113 genes from the "Illumina" protocol. In case …

  • 0 views
  • 14 Oct, 2022
  • 1 location
ScreenIng of Genetic Susceptibility Genes for Breast Cancer Patients in CHinese communiTies (SIGHT)

who voluntarily participate to carry out the detection of BRCA1, BRCA2, PTEN, CHEK2 and PALB2 genes through the community health service center.

BRCA2
palb2
BRCA1
CHEK2
PTEN
  • 0 views
  • 11 May, 2022
  • 1 location
Multifactorial Risk Assessment for Breast & Ovarian Cancer Risk Detection

The objective of this project is to validate a next-generation assay that utilizes both the protein biomarkers of our already established ovarian cancer risk assessment combined with a molecular profile in both germline and early somatic detection.

  • 0 views
  • 04 Oct, 2022
  • 1 location
Prospective Study of MAstectomy With Reconstruction Including Robot Endoscopic Surgery

Robotic mastectomy and immediate reconstruction have been introduced recently in 2015. However, since robotic mastectomy is latest surgical technique, there is a lack of studies comparing conventional mastectomy and immediate reconstruction with robotic mastectomy prospectively. For this reason, this study is designed to establish a single institution cohort study that …

TP53
palb2
BRCA1
BRCA1/2
mastectomy
  • 0 views
  • 20 Jun, 2021
  • 1 location
Analysing Outcomes After Prostate Cancer Diagnosis and Treatment in Carriers of Rare Germline Mutations (GENPROS)

GENPROS aims to analyse the outcomes of patients with rare gene mutations in the cancer predisposition genes, BRCA1, BRCA2, HOXB13, and Lynch Syndrome, after a diagnosis of and treatment for

BRCA2
BRCA1
  • 2 views
  • 25 Apr, 2022
  • 1 location
Clinical Significance of Germline BRCA Mutations

mutations in the BRCA1 and BRCA2 genes alone or as part of a panel of genes associated with breast cancer predisposition. New technologies are being employed for identification of patients with a

BRCA2
triple negative breast cancer
BRCA1
breast cancer
cancer of the ovary
  • 16 views
  • 22 Oct, 2022
  • 7 locations
An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk

The purpose of this study is to evaluate a cascade genetic testing intervention. Cascade testing is the process of offering genetic testing to people who are at risk of having inherited a possibly harmful gene change that has been found in their family. This process is repeated as more people …

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 8 locations