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Found 124 clinical trials
A Study of Melphalan, BCNU, Vitamin B12b, Vitamin C, and Stem Cell Infusion in People With Advanced Pancreatic Cancer and BRCA Mutations

The clinical trial is a phase 1, single-arm trial that will evaluate the safety of the investigational treatment on pancreatic cancer in patients who have an inherited, deleterious BRCA1 or

BRCA2
cancer chemotherapy
BRCA1
  • 14 views
  • 08 Jun, 2022
  • 2 locations
Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations (ORCHID)

, BRCA1, BRCA2, PALB2, CHEK2, BRIP1, RAD51C, BARD1, CDK12, CHEK1, FANCL, PP2R2A, RAD51B, RAD51D, or RAD54L who have had prior treatment with at least one immune checkpoint inhibitor or anti-VEGF

CDK12
platelet count
hysterectomy
serum pregnancy test
BARD1
  • 21 views
  • 09 Feb, 2022
  • 1 location
A Study of ZEN003694 and Talazoparib in Patients With Triple Negative Breast Cancer (TNBC)

This is a two-part open label, non-randomized, Phase 2, study of ZEN003694 in combination with Talazoparib in patients with TNBC without germline mutations of BRCA1 or BRCA2. Part 1 is a dose

estrogen
cancer
erbb2
measurable disease
breast cancer
  • 0 views
  • 27 Jul, 2022
  • 10 locations
Veliparib and Dinaciclib in Treating Patients With Advanced Solid Tumors

This phase I trial studies the side effects and the best dose of veliparib and dinaciclib in treating patients with solid tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment. Veliparib and dinaciclib may stop the growth of tumor cells …

nitrosoureas
blood transfusion
tumor cells
international normalized ratio
parp inhibitor
  • 6 views
  • 14 Jul, 2022
  • 1 location
Pilot Study of Single-port Robot-assisted Nipple-sparing Mastectomy

pathogenic or likely pathogenic BRCA1/2 mutations are recruited to receive SP-assisted unilateral or bilateral NSMs. Immediate breast reconstruction is followed according to the mode of the plastic

anesthesia
breast cancer
cancer
BRCA1
axillary lymph node dissection
  • 0 views
  • 11 Aug, 2022
  • 1 location
Olaparib In Metastatic Breast Cancer

with BRCA1 and BRCA2 to repair damaged DNA .This mutation may have been inherited from a parent, or may have developed only in the tumor. This study will also evaluate whether olaparib is

bisphosphonate
estrogen
hysterectomy
hormone therapy
measurable disease
  • 220 views
  • 12 Jul, 2022
  • 18 locations
Prostate Screening Study Using MRI in BRCA Carriers

Men with a BRCA1 or BRCA2 mutation are at increased risk for early onset, aggressive prostate cancer compared to men in the general population. Standard of care screening for men with a

digital rectal examination
BRCA1
BRCA2
transrectal ultrasound
  • 11 views
  • 25 May, 2022
  • 1 location
Biomarkers for Early Detection of Ovarian Cancer Using Uterine Lavage

cancer develop in the fallopian tubes, hence the universal recommendation for high-risk populations (e.g., BRCA1/2 mutation carriers) is to undergo risk-reducing bilateral salpingo-oophorectomy (RRBSO

cavity
oophorectomy
fallopian tube
BRCA1
cancer
  • 8 views
  • 24 Jan, 2021
  • 5 locations
Phase 2 Trial of the Combination of the BET Inhibitor, ZEN003694 (ZEN-3694), and the PARP Inhibitor Talazoparib, in Patients With Molecularly-Selected Solid Tumors (ComBET)

DNA code that individuals inherit from their parents. Some genes work to protect against cancer by correcting damage that can occur in the DNA when cells divide. BRCA1 and BRCA2 are two examples of

  • 0 views
  • 17 Sep, 2022
  • 1 location
Pharmacokinetic Boosting of Olaparib to Improve Exposure, Tolerance and Cost-effectiveness (PROACTIVE)

added to the drug label, such as first-line platinum-sensitive BRCA-mutated high grade serious epithelial ovarian, fallopian tube, or peritoneal cancer, germline BRCA1/2-mutated, human epidermal growth

growth factor
breast cancer
BRCA1
treatment regimen
primary cancer
  • 0 views
  • 21 Sep, 2022
  • 1 location