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Found 124 clinical trials
Trial of Pembrolizumab in Metastatic Castration Resistant Prostate Cancer

PERSEUS1 is an open-label, single arm, phase II trial evaluating the efficacy of Pembrolizumab in metastatic castration resistant prostate cancer (mCRPC) patients (Part A) with a biomarker enrichment stage (Part B) if efficacy is shown in part A.

neutrophil count
testosterone
bone disease
direct bilirubin
antiandrogen therapy
  • 0 views
  • 24 Jan, 2021
  • 1 location
Niraparib in Combination With Cabozantinib (XL184) in Patients With Advanced Urothelial Cancer (NICARAGUA) (NICARAGUA)

Cabozantinib is an oral, small-molecule tyrosine kinase inhibitor. Its primary targets are Hepatocyte growth factor receptor protein (MET), vascular endothelial growth factor receptor 1-3 (VEGFR1-3), RET, AXL, FLT3 and KIT. Cabozantinib has been approved by the FDA for clinical treatment of progressive, metastatic medullary thyroid cancer. Recently published trials have …

neutrophil count
oophorectomy
progressive disease
RET
serum pregnancy test
  • 46 views
  • 26 Mar, 2022
  • 9 locations
Efficacy of Lifestyle Intervention in BRCA1/2 Mutation Carriers

The hypothesis of this 3 year, prospective randomized multicenter efficacy trial is that a structured life-style intervention program with exercise training and mediterranean diet is effective regarding increased adherence to a mediterranean diet, reduction of body mass index, and increase of physical fitness.

  • 83 views
  • 25 Apr, 2021
  • 20 locations
A Study to Compare Two Surgical Procedures in Women With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

This trial studies how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for women with BRCA1 mutations

cancer antigen 125
oophorectomy
ca 125
hysterectomy
luteinizing hormone
  • 98 views
  • 19 Jun, 2022
  • 186 locations
FaCT Trial (Facilitated Cascade Testing Trial)

The purpose of this study is to assess an intervention that incorporates engagement strategies with a medical team navigator, an educational video and accessible genetic testing services to maximize the genetic testing and education of at-risk relatives. In this study, first degree relatives who agree to participate will either receive …

Accepts healthy volunteers
  • 0 views
  • 03 May, 2022
  • 3 locations
Interest of Broadband Spectroscopy Analysis by Infrared Laser on Liquid Biopsies in Breast Cancer Screening (ICRG0101)

The purpose of this study is to validate the interest of broadband spectroscopy analysis (femto/attosecond by infrared laser) on liquid biopsies in breast cancer screening.

Accepts healthy volunteers
  • 0 views
  • 23 Apr, 2022
  • 5 locations
Study of Family COsegregation of Nucleotide VARiants in the Panel of Genes to Validate Their Use in Genetic Counseling (COVAR)

The aim of the COVAR project is to classify reliably a maximum of VUS of the French database in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some …

KIT
BRCA2
palb2
BRCA1
cancer of the ovary
  • 17 views
  • 19 Sep, 2022
  • 57 locations
TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

The aim of the project is to evaluate the risk-reducing salpingectomy with delayed oophorectomy as an alternative for risk-reducing salpingo-oophorectomy in high risk women with respect to ovarian cancer incidence.

BRCA2
oophorectomy
rad51c
BRCA1
ovarian cancer
  • 0 views
  • 09 Oct, 2021
  • 14 locations
Stand up to Cancer: MAGENTA (Making Genetic Testing Accessible)

This randomized clinical trial studies how well online genetics educational video with or without pre- and/or post-telephone genetics counseling works in assessing cancer-risk distress in patients with triple negative breast cancer. Online genetic education and telephone genetic counseling may help the doctors learn the stress a person feels about their …

epidermal growth factor receptor
genetic counseling
human epidermal growth factor
palb2
breast cancer
  • 24 views
  • 01 Jul, 2022
  • 2 locations
Identifying and Caring for Individuals With Inherited Cancer Syndrome

This trial examines approaches to identify and care for individuals with inherited cancer syndrome. The purpose of this study is to offer no cost genetic testing to the general public. Researchers hope to learn the value of providing broad, public-wide testing for high risk cancer types (like hereditary breast and …

carcinoma in situ
BRCA2
ductal carcinoma
genetic testing
BRCA1
  • 21 views
  • 23 Mar, 2022
  • 2 locations