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Found 179 clinical trials
Appropriate Dosing to Optimise Personalised Cancer Treatments

This is a pilot study to assess feasibility of dried blood spot (DBS) samples for pharmacokinetic measurements of targeted anti-cancer drugs in oncology patients such as patients with BRAF

ovarian carcinoma
cancer of the ovary
KIT
cancer
advanced renal cell carcinoma
  • 0 views
  • 25 Jan, 2021
  • 1 location
Effectiveness and Safety of Dabrafenib in Combination With Trametinib as Adjuvant Treatment for Chinese Patients With Stage III BRAF V600 Mutation-positive Melanoma After Complete Resection

This is a prospective, open label, single-arm, multicenter, non-interventional study of dabrafenib in combination with trametinib as adjuvant treatment for Chinese patients with stage III BRAF

braf v600 mutation
trametinib
dabrafenib
immunologic adjuvant
immunomodulators
  • 0 views
  • 23 Jul, 2021
  • 4 locations
Study of CT and MR in the Lung Cancer

), ROS1(c-ros oncogene 1 receptor,ROS1), BRAF (V-raf murine sarcoma viral oncogene homolog B1, BRAF)and so on have clearly targeted drugs, which bring survival benefits to patients. However, about half

cancer
EGFR
ROS1
lung cancer
epidermal growth factor receptor
  • 0 views
  • 24 Jan, 2021
  • 1 location
OPTImal PALliative Anti-epidermal Growth Factor Receptor Treatment in Metastatic Colorectal Cancer -

The present study will investigate the feasibility and clinical value of using circulating tumor DNA as selection for anti-epidermal growth factor receptor treatment for metastatic colorectal cancer.

growth factor
  • 0 views
  • 28 Jan, 2021
  • 1 location
Efficacy and Safety of the Combination of Anlotinib and JS001 in EGFR-TKI Resistant T790M-Negative NSCLC

This study is designed to evaluate the efficacy and safety of the combination of Anlotinb and JS001 in EGFR-TKI resistant T790M-negative NSCLC patients.

  • 0 views
  • 23 Jan, 2021
  • 1 location
Tracing Dissemination of Melanoma Cells in Healthy Tissues

The objective of this project is to evaluate the presence of melanoma quiescent or initiating clonal cells in peritumoral healthy tissue displaying the same molecular signature than those of the tumor/metastasis and to correlate this presence to the prognostic value.

metastasis
KIT
NRAS
BRAF
  • 10 views
  • 27 Apr, 2021
  • 1 location
Predictive Value of Innovative Prognostic Markers (Gut Microbiota Sarcopenia Metabolic Syndrome and Obesity) on Surgical and Oncologic Results in the Management of Sporadic Colorectal Adenocarcinoma.

Colorectal cancer (CRC), second leading cause of cancer worldwide, is associated with a poor prognosis, especially in patients with advanced disease. Therefore, there is still a need to develop new prognostic tools to replace or supplement those routinely used, with the aim to optimize treatment strategies. Studies on gut microbiota …

  • 0 views
  • 22 Jan, 2021
  • 1 location
Circulating Tumor DNA as Marker for Response to Antineoplastic Treatment of Metastatic Cancer (FLUIDO)

Early monitoring of antineoplastic treatment benefit is a central medical need. Radiologic assessment for documentation of response is done after several months of treatment usually. This implies that patients not responding are exposed to unnecessary toxicity. According to several reports showing the correlation of the amount of circulating tumour DNA …

  • 0 views
  • 18 Mar, 2021
  • 1 location
Monitoring Mutational Burden in Low Risk MDS Patients Using Sequential Peripheral Blood Samples

Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell malignancies. Somatic cytogenetic and molecular aberrations and the evolution of subclonal malignant cell populations are responsible for the development and progression of MDS into acute myeloid leukemia. Within only one decade the availability of new genome-wide technologies, like …

cancer
leukemia
bone marrow procedure
myeloid leukemia
erythropoietin
  • 0 views
  • 08 Aug, 2021
  • 1 location