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Found 171 clinical trials
Identification and Treatment Of Micrometastatic Disease in Stage III Colon Cancer

This research study is comparing two standard of care treatment options based on blood test results for participants who have metastatic colorectal cancer. The names of the potential treatments involved in this study are: Active surveillance FOLFIRI treatment Nivolumab treatment Encorafenib/Binimetinib/Cetuximab treatment

folfiri regimen
nivolumab
adjuvant chemotherapy
oxaliplatin
leucovorin
  • 0 views
  • 25 Feb, 2022
EXtended CriteriA Treatment for LIver Metastases and Heavy Tumour BURden

Patients with multiple colorectal liver metastases that progress on 1st line chemotherapy have a very dismal prognosis, and their options are few. Resections are regularly performed although this is only supported by anecdotal evidence for this patient group. We want to assess whether resections actually confer benefit as compared to …

  • 0 views
  • 01 Jul, 2021
  • 1 location
Selective Treatment According to Molecular Subtype of Prostate Cancer (STAMP)

This is an open-label study that includes three substudies of random distribution. First, a sample of the primary tumor will be obtained and will be analyzed by an immunohistochemical technique to determine several markers. Depending on the expression of these markers, the patients will be characterize as group 1 (Luminal …

testosterone
serum testosterone
  • 1 views
  • 14 Feb, 2022
  • 1 location
Concordance in MRI and Pathology Diagnosis of Extranodal Tumour Deposits (COMET)

Predicting prognosis in rectal cancer and determining indications for neoadjuvant treatment is an ongoing challenge for colorectal multidisciplinary teams (MDTs). Staging is almost universally based on the TNM system which, despite multiple changes and increasing levels of sub-classification and complexity, is still flawed in its ability to stratify patients and …

cancer
adjuvant therapy
rectal carcinoma
  • 0 views
  • 30 Jan, 2022
  • 1 location
NCT Neuro Master Match - N²M² (NOA-20) (N²M²)

The objective of N²M² is the improvement of overall survival of patients with glioblastoma with an unmethylated MGMT promoter based on molecular characterization and use of targeted compounds in a modern trial design. The progression-free survival rate at six months (PFS-6) will be used to make decisions.

  • 14 views
  • 08 Jun, 2022
  • 13 locations
BRAINFUL (BRAIN Tumor Focused Ultrasound-enabled Liquid Biopsy) Trial

Background Accessing brain tumor material for pathological diagnosis requires invasive procedures that carry risk to patients including brain hemorrhages and death. Liquid biopsies are emerging non-invasive alternatives to direct tumour biopsies but the abundance of circulating tumor DNA (ctDNA) is relatively low and this limits our ability to accurately make …

  • 0 views
  • 18 Jul, 2021
  • 1 location
HAI-Floxuridine or Liver-Tx Combined With 2nd Line Chemotherapy Versus 2nd Line Chemotherapy Alone for Patients With Colorectal Livermetasteses and Heavy Tumour Burden.

Patients with colorectal livermetasteses and heavy tumour burden and progression on 1st line chemotherapy have no other available treatment in Norway today other than 2nd line chemotherapy. The Investigators will randomize patients younger than 70 yrs old to HAI-floxuridine, or liver-Tx, in addition to 2nd line chemotherapy versus 2nd line …

  • 0 views
  • 15 Jul, 2021
  • 1 location
Mechanism of Sorafenib Resistance in Patients With Advanced Hepatocellular Carcinoma

It has been shown previously that gene expression profiling signature (a set of dysregulated genes) can be used for molecular classification, diagnosis, and prognosis of several types of cancers. In This study the hypothesise that resistant tumor may be due to genetic mutations and/or other alternative pathways that could be …

cancer
international normalized ratio
vascular invasion
platelet count
coumadin
  • 16 views
  • 23 Jan, 2021
  • 1 location
Endoscopic Surveillance in Serrated Polyposis Syndrome and Low-risk of Advanced Neoplasia

The aim of the study is to determine if Serrated Poliposis Syndrome (SPS) patients with SPS criteria 2, with clearing phase achieved and without any advanced lesion or less than 5 relevant lesions at last colonoscopy have the same advanced neoplasia incidence in the surveillance colonoscopy at 2 or 3 …

colonoscopy
cancer
chromoendoscopy
adenoma
polypectomy
  • 2 views
  • 30 Sep, 2021
  • 1 location
Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study) (ABC-X)

This is a phase II, open label, randomised trial of ipilimumab and nivolumab with concurrent intracranial stereotactic radiotherapy versus ipilimumab and nivolumab alone in patients with asymptomatic, untreated melanoma brain metastases.

  • 16 views
  • 04 Oct, 2022
  • 5 locations