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Found 9 clinical trials
Testing Olaparib in Patients With Advanced or Metastatic (Cancer That Has Spread) Bladder Cancer With DNA-Repair Genetic Changes

This phase II trial studies how well olaparib works in treating patients with urothelial cancer with deoxyribonucleic acid (DNA)-repair defects that has spread to other places in the body (advanced or metastatic) and usually cannot be cured or controlled with treatment. PARPs are proteins that help repair DNA mutations. PARP …

metastasis
avelumab
neutrophil count
atezolizumab
cancer
  • 111 views
  • 20 Jun, 2022
  • 1 location
Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies

This is a multi-institutional Phase I dose-escalation and dose-expansion trial for patients with advanced, solid tumor malignancies who have pre-identified deleterious germline or somatic mutations in the homologous recombination deoxyribonucleic acid (DNA) repair pathway (HR deficient). The trial is designed to assess the efficacy and safety of niraparib plus carboplatin …

carboplatin
serum pregnancy test
solid tumor
advanced solid tumor
neutrophil count
  • 7 views
  • 09 Sep, 2021
  • 3 locations
A Prospective Natural History Study in Uveal Melanoma

The overall objective of this proposal is to develop and utilize a multicenter UM registry that will, in a longitudinal fashion, capture prospective data in order to characterize the natural history of UM and provide data that will be used to support the development of novel therapies for this disease. …

  • 0 views
  • 25 Mar, 2021
  • 2 locations
Long Term Follow-up of Mesothelioma Patients and Their Family Members With Germline Mutations in BAP1 and Other Genes

in the BAP1 gene can cause mesothelioma and other cancers. Researchers want to study people with germline mutations of BAP1 and other genes known to cause cancer. Objective

cancer
BAP1
skin lesions
blood test
  • 5 views
  • 28 Jun, 2022
  • 1 location
Prospective Evaluation of Photon Counting Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome

. Germline mutations in a gene called BAP1 are linked to the development of mesothelioma and other cancers. Researchers want to follow people with these mutations to learn more. Objective

thoracoscopy
cancer
Accepts healthy volunteers
BAP1
  • 0 views
  • 19 Jun, 2022
  • 1 location
Homologous Recombination Deficiency Status in Epithelial Ovarian Cancer

testing of 36 genes would be given for these patients in their peripheral blood and tumor tissues. These 36 genes include: BRCA1, BRCA2, ABRAXAS1(FAM175A, ATM, ATR, BAP1, BARD1, BRIP1, C11ORF30EMSY

RAD54B
EPCAM
rad51c
BRIP1
fancl
  • 0 views
  • 21 Feb, 2022
  • 1 location
Familial Investigations of Childhood Cancer Predisposition (SJFAMILY)

NOTE: This is a research study and is not meant to be a substitute for clinical genetic testing. Families may never receive results from the study or may receive results many years from the time they enroll. If you are interested in clinical testing please consider seeing a local genetic …

familial cancer
cancer
genetic testing
biological factors
childhood cancer
  • 213 views
  • 25 May, 2022
  • 1 location
Frequency and Clinical Phenotype of BAP1 Hereditary Predisposition Syndrome

BAP1. Our study will ultimately facilitate the development of novel screening, prevention and treatment strategies for these individuals with the syndrome. Because the vast majority of UM develop in

  • 0 views
  • 19 Mar, 2021
  • 1 location
Development and Evaluation of High Risk Group Prediction Model in T1 Stage Renal Cell Cancer Using Molecular Biomarkers

For the appropriate individualized treatment of T1-stage renal cell carcinoma with heterogeneous biological features, the expression of PBRM1, SETD2, BAP1, KDM5C and the newly proposed FOXC2 and

  • 10 views
  • 23 Jan, 2021