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Found 54 clinical trials
Elimusertib for the Treatment of Relapsed or Refractory Solid Tumors

This phase I/II trial tests the safety, best dose, and whether elimusertib works in treating patients with solid tumors that have come back (relapsed) or does not respond to treatment (refractory). Elimusertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

  • 21 Jan, 2022
  • 5 locations
A Non-pharmacological Intervention for Patients With Alzheimer's Disease and Family Caregivers (Care Partners Program)

The proposed study will develop and test the efficacy and feasibility of a dyadic-based intervention program (DT), delivered through state-of-the art computer tablet technology. A novel feature of the investigation is its focus on both the caregiver and the recipient of care (person with AD) and the integration of an …

  • 30 Sep, 2021
  • 2 locations
Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies

This is a multi-institutional Phase I dose-escalation and dose-expansion trial for patients with advanced, solid tumor malignancies who have pre-identified deleterious germline or somatic mutations in the homologous recombination deoxyribonucleic acid (DNA) repair pathway (HR deficient). The trial is designed to assess the efficacy and safety of niraparib plus carboplatin …

advanced solid tumor
neutrophil count
solid tumor
  • 09 Sep, 2021
  • 3 locations
A Novel Computer-Based Functional Skills Assessment and Training Program

People with cognitive impairments such as Mild Cognitive Impairment (MCI), often experience difficulty performing everyday routine activities. Further, normative age-related changes in cognition often lead to deficits on previously learned skills and impede new learning such as learning of new technology systems. This is of great concern, given population aging, …

Accepts healthy volunteers
  • 25 Jan, 2022
  • 2 locations
Strategic Targeting for Optimal Prevention of Cancer

The primary goal of the study is to record data over the observation period to evaluate the clinical benefit of using hereditary cancer genomic diagnostics to assess overall hereditary genetic cancer risk profile and to help guide physicians to pursue preventative measures, which may lead to early detection and treatment …

  • 27 Aug, 2021
  • 2 locations
Pancreatic Cancer Registry: For Any Person With a Personal or Family History

clustering in subsets of families. For example, in 2009 and 2012 the investigators discovered that mutations in the PALB2 and ATM genes jointly account up to 5% of the clustering of pancreatic cancer in

pancreatic neoplasm
Accepts healthy volunteers
  • 09 Dec, 2021
  • 1 location
Homologous Recombination Deficiency Status in Epithelial Ovarian Cancer

testing of 36 genes would be given for these patients in their peripheral blood and tumor tissues. These 36 genes include: BRCA1, BRCA2, ABRAXAS1(FAM175A, ATM, ATR, BAP1, BARD1, BRIP1, C11ORF30EMSY

  • 23 Jan, 2021
  • 1 location
Clinical Application of Genetic Sequencing of Early Gastric Cancer and Gastric Adenoma Patients

Because advanced gastric cancer shows poor prognosis, it is important to detect early gastric cancer or precancerous gastric adenoma patients who have a cure rate of 95% or more. Moreover, a large part of early gastric cancer can be completely resected by endoscopic resection, thus ensuring a very high quality …

  • 28 Jan, 2021
  • 1 location
The PROFILE Study: Germline Genetic Profiling: Correlation With Targeted Prostate Cancer Screening and Treatment

Prostate cancer is now the commonest cancer in men in the Western world, with over 49,000 new cases diagnosed each year and a lifetime risk of 1 in 11 in the United Kingdom. Prostate cancer (PrCa) can run in some families and research studies have identified several genetic changes in …

prostate cancer screening
prostate specific antigen
  • 21 Jun, 2021
  • 1 location
Tissue Collection for Correlation Between ATM Alterations by Next-Generation Sequencing and ATM Loss-of-Protein

This study examines the correlation between ATM alterations identified using NGS profiles with ATM protein expression levels from tumor tissue assessed by IHC.

  • 03 Aug, 2021
  • 2 locations