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Found 53 clinical trials
Elimusertib for the Treatment of Relapsed or Refractory Solid Tumors

This phase I/II trial tests the safety, best dose, and whether elimusertib works in treating patients with solid tumors that have come back (relapsed) or does not respond to treatment (refractory). Elimusertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

  • 0 views
  • 09 Aug, 2022
  • 14 locations
A Novel Computer-Based Functional Skills Assessment and Training Program

People with cognitive impairments such as Mild Cognitive Impairment (MCI), often experience difficulty performing everyday routine activities. Further, normative age-related changes in cognition often lead to deficits on previously learned skills and impede new learning such as learning of new technology systems. This is of great concern, given population aging, …

Accepts healthy volunteers
  • 0 views
  • 25 Jan, 2022
  • 2 locations
Strategic Targeting for Optimal Prevention of Cancer (STOP-Cancer)

The primary goal of the study is to record data over the observation period to evaluate the clinical benefit of using hereditary cancer genomic diagnostics to assess overall hereditary genetic cancer risk profile and to help guide physicians to pursue preventative measures, which may lead to early detection and treatment …

  • 14 views
  • 09 Feb, 2022
  • 1 location
Pancreatic Cancer Registry: For Any Person With a Personal or Family History (NFPTR)

clustering in subsets of families. For example, in 2009 and 2012 the investigators discovered that mutations in the PALB2 and ATM genes jointly account up to 5% of the clustering of pancreatic cancer in

palb2
ATM
Accepts healthy volunteers
pancreatic neoplasm
  • 29 views
  • 10 Jul, 2022
  • 1 location
Homologous Recombination Deficiency Status in Epithelial Ovarian Cancer

testing of 36 genes would be given for these patients in their peripheral blood and tumor tissues. These 36 genes include: BRCA1, BRCA2, ABRAXAS1(FAM175A, ATM, ATR, BAP1, BARD1, BRIP1, C11ORF30EMSY

MSH6
BRIP1
MSH2
STK11
BARD1
  • 0 views
  • 21 Feb, 2022
  • 1 location
An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk

The purpose of this study is to evaluate a cascade genetic testing intervention. Cascade testing is the process of offering genetic testing to people who are at risk of having inherited a possibly harmful gene change that has been found in their family. This process is repeated as more people …

Accepts healthy volunteers
  • 0 views
  • 10 Aug, 2022
  • 8 locations
Clinical Application of Genetic Sequencing of Early Gastric Cancer and Gastric Adenoma Patients

Because advanced gastric cancer shows poor prognosis, it is important to detect early gastric cancer or precancerous gastric adenoma patients who have a cure rate of 95% or more. Moreover, a large part of early gastric cancer can be completely resected by endoscopic resection, thus ensuring a very high quality …

  • 0 views
  • 28 Jan, 2021
  • 1 location
The PROFILE Study: Germline Genetic Profiling: Correlation With Targeted Prostate Cancer Screening and Treatment (PROFILE)

Prostate cancer is now the commonest cancer in men in the Western world, with over 49,000 new cases diagnosed each year and a lifetime risk of 1 in 11 in the United Kingdom. Prostate cancer (PrCa) can run in some families and research studies have identified several genetic changes in …

prostate cancer screening
Accepts healthy volunteers
prostate specific antigen
  • 1 views
  • 25 Apr, 2022
  • 1 location
Preliminary Evaluation of Screening for Pancreatic Cancer in Patients With Inherited Genetic Risk

high risk for pancreatic cancer, specifically those with BRCA1/2, ATM, or PALB2 mutations.

palb2
BRCA2
BRCA1
endoscopic ultrasound
ATM
  • 10 views
  • 15 Jun, 2022
  • 1 location
Pilot Study of Pancreatic Cancer Screening

gene (ATM), or PALB2 screened for pancreatic cancer. This study may lead to a greater understanding of cancer and potentially, improvements in cancer screening and treatment.

palb2
ATM
Accepts healthy volunteers
endoscopic ultrasound
  • 0 views
  • 29 Apr, 2022
  • 1 location