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Found 54 clinical trials
High Dose Testosterone for ATM CDK12 or CHEK2 Altered Prostate Cancers

This study will determine whether the presence of DNA repair deficiency in the form of alterations in the genes ATM, CDK12 or CHEK2 predicts for a high likelihood of responding to the use of

  • 0 views
  • 23 Sep, 2021
  • 10 locations
A Study of Reduced-dose Radiation in People With Metastatic Tumors With a Genetic Change

This study will test whether reduced-dose radiotherapy is an effective treatment for metastatic tumors with an ATM mutation. The researchers want to find the lowest dose of radiation that would

  • 0 views
  • 01 Oct, 2021
  • 7 locations
Study of Olaparib in Metastatic Renal Cell Carcinoma Patients With DNA Repair Gene Mutations

Single arm, single site, open-label Phase II study of the effects of oral olaparib in participants with metastatic renal cell carcinoma that harbor an inactivating mutation in BAP-1, ATM

cytokines
vascular endothelial growth factor
RAD54L
neutrophil count
rad51c
  • 19 views
  • 21 Mar, 2021
  • 1 location
A Study of APG-115 in Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors

and ATM mutation, P53 WT and MDM2 amplification liposarcomas, PD-1/PD-L1 refractory/relapsed urothelial carcinoma without FGFR translocation mutation, and MPNST.

alopecia
measurable disease
growth factor
metastatic melanoma
pembrolizumab
  • 33 views
  • 16 Jan, 2022
  • 19 locations
Trial of XRD-0394 a Kinase Inhibitor in Combination With Palliative Radiotherapy in Advanced Cancer Patients

XRD-0394 is a novel, potent, oral, small molecule dual inhibitor of ataxia telangiectasia mutated kinase (ATM) and deoxyribonucleic acid (DNA)-dependent protein kinase (DNA-PK) that has

cancer
  • 1 views
  • 07 Oct, 2021
  • 2 locations
Talazoparib in Treating Patients With Recurrent Refractory Advanced or Metastatic Cancers and Alterations in the BRCA Genes

This phase II trial studies how well talazoparib works in treating patients with cancers that have returned after a period of improvement, do not respond to treatment, or have spread to other parts of the body, and have alterations in the breast cancer, early onset (BRCA) genes. Talazoparib may cause …

cancer
measurable disease
direct bilirubin
biomarker analysis
neutrophil count
  • 10 views
  • 15 Jun, 2021
  • 2 locations
Olaparib In Metastatic Breast Cancer

This research study is for patients with metastatic breast cancer. Metastatic means that the cancer has spread beyond the breast. In addition, through genetic testing of the blood or tumor, an altered gene has been found that suggests the tumor may not be able to repair its genetic material (DNA) …

docetaxel
measurable disease
cancer chemotherapy
estrogen
neutrophil count
  • 201 views
  • 25 Sep, 2021
  • 20 locations
Chk2 Inhibitor for Recurrent EpitheliAl periToneal fallopIan or oVarian cancEr (CREATIVE Phase IA Trial)

that is a checkpoint kinase binding specifically to CHK2, rather than CHK1, and it inhibits the DDR system by inhibiting the ATM-CHK2 pathway, which is activated in response to DSBs. When a high-grade

  • 2 views
  • 29 Jan, 2021
  • 1 location
Docetaxel Carboplatin and Rucaparib Camsylate in Treating Patients With Metastatic Castration Resistant Prostate Cancer With Homologous Recombination DNA Repair Deficiency

This phase II trial studies how well docetaxel with carboplatin followed by rucaparib camsylate works in treating patients with metastatic castration resistant prostate cancer (spread outside of prostate and resistant to testosterone suppression) with homologous recombination DNA repair deficiency. Chemotherapy drugs, such as docetaxel and carboplatin, work to stop the …

docetaxel
antiandrogen therapy
cancer
carboplatin
sipuleucel-t
  • 18 views
  • 30 Nov, 2021
  • 1 location
Olaparib in Treating Patients With Metastatic Biliary Tract Cancer With Aberrant DNA Repair Gene Mutations

This phase II trial studies how well olaparib works in treating patients with biliary tract cancer that has spread to other places in the body (metastatic) and with aberrant DNA repair gene mutations. Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell …

cancer
measurable disease
follicle stimulating hormone
tumor cells
luteinizing hormone (lh)
  • 0 views
  • 12 Jan, 2022
  • 4 locations