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Found 67 clinical trials
Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients With Progressive Meningiomas

This phase II trial studies how well vismodegib, focal adhesion kinase (FAK) inhibitor GSK2256098, and capivasertib work in treating patients with meningioma that is growing, spreading, or getting worse (progressive). Vismodegib, FAK inhibitor GSK2256098, capivasertib, and abemaciclib may stop the growth of tumor cells by blocking some of the enzymes …

vismodegib
tumor cells
gsk2256098
  • 4 views
  • 25 Jul, 2022
  • 511 locations
Selective Treatment According to Molecular Subtype of Prostate Cancer (STAMP)

This is an open-label study that includes three substudies of random distribution. First, a sample of the primary tumor will be obtained and will be analyzed by an immunohistochemical technique to determine several markers. Depending on the expression of these markers, the patients will be characterize as group 1 (Luminal …

testosterone
serum testosterone
  • 1 views
  • 14 Feb, 2022
  • 1 location
Treatment of Dalpiciclib Combined With Pyrotinib for Trastuzumab-sensitive HER2+ Advanced Breast Cancer(DAP-Her-02)

Based on different HR status, we explored the efficacy and safety of Pyrotinib and Dalpiciclib Isethionate Tablets based combination regimen in the first-line treatment of HER2 + MBC.

advanced breast cancer
growth factor
estrogen
hormone therapy
endocrine therapy
  • 0 views
  • 15 Jun, 2022
  • 1 location
Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer

This phase II trial studies the effect of megestrol acetate alone or in combination with metformin in preventing the progression of uterine pre-cancer (endometrial intraepithelial neoplasia) to endometrial cancer. Megestrol acetate is a drug used to block estrogen and suppress the effects of estrogen and androgens. It is the current …

hyperplasia
hysterectomy
megestrol
estrogen
uterine disease
  • 0 views
  • 15 Jul, 2022
  • 5 locations
Rapamycin Treatment for Activated Phosphoinositide 3-Kinase δ Syndrome

The purpose of this proposed research is to evaluate the efficacy and safety of the rapamycin therapy in patients with activated phosphoinositide 3-kinase δ syndrome (APDS).

rapamycin
immunodeficiency
  • 0 views
  • 07 Apr, 2022
  • 1 location
Study to Evaluate the Effect of Metformin in the Prevention of HG in HR[+]/HER2[-] PIK3CA-mut Advanced BC Patients (METALLICA)

Men and post- or induced menopausal women with ER[+] and/or PgR[+], HER2[- ] advanced BC, with centrally-confirmed PI3KCAMut who progressed to an aromatase inhibitor (AI) regimen.

erbb2
PIK3CA
aromatase inhibitor
HER2
fulvestrant
  • 0 views
  • 18 Apr, 2022
  • 14 locations
Evaluating Safety and Efficacy of Tivozanib (AV-951) in Cholangiocarcinoma

Background Cholangiocarcinoma (CCA) is an aggressive cancer of the bile ducts. People with CCA have few treatment options and poor survival. Researchers want to see if a new drug can stop or slow CCA growth. Objective To find the safest and most effective dose of tivozanib to treat CCA and …

cancer
neutrophil count
  • 0 views
  • 29 Jul, 2022
  • 1 location
Study to Evaluate the Efficacy and Safety of Sirolimus in Subjects With Metastatic, Mismatch Repair Deficient Solid Tumors After Immunotherapy

To evaluate the efficacy of sirolimus by estimating the overall response rate (ORR) as assessed by Response Evaluation Criteria In Solid Tumors version 1.1 (RECIST v1.1) in patients with metastatic dMMR solid cancer after immunotherapy (either due to disease progression or to inability to tolerate treatment).

primary cancer
cancer
solid tumour
neutrophil count
solid neoplasm
  • 0 views
  • 14 Jun, 2022
  • 1 location
CCRT With Itraconazole in Locally Advanced Squamous Esophageal Cancer

The objective of this study is to evaluate the efficacy and safety of concurrent chemoradiotherapy combined with Itraconazole in patients with locally adcvanced esophageal squamous cancer

esophagus cancer
esophageal cancer
squamous cell carcinoma of esophagus
esophageal carcinoma
squamous cell carcinoma
  • 0 views
  • 26 Jan, 2021
  • 1 location
Radiosensitizing Effect of Nelfinavir in Locally Advanced Carcinoma of Cervix (NELCER)

The primary aim of the trial is to study the impact of nelfinavir on 3 year disease free survival in patients with advanced carcinoma of cervix receiving standard chemoradiation (Cisplatin and Radiotherapy). There will be two study groups. One group will receive standard treatment (concurrent chemoradiation and brachytherapy) & other …

  • 1 views
  • 12 Mar, 2022
  • 1 location