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Found 67 clinical trials
Clinical Trial on Remote Ischemic Conditioning in Acute Ischemic Stroke Within 9 Hours of Onset in Patients Ineligible to Recanalization Therapies (TRICS-9)

Phase II, prospective, randomized, multicenter, open-label, pilot clinical trial comparing remote ischemic conditioning (RIC) plus standard medical therapy to standard medical therapy alone, in patients with acute ischemic stroke within 9 hours of stroke onset that are not eligible to recanalization therapies.

  • 10 views
  • 15 Jul, 2022
  • 3 locations
AKT Inhibitor, Ipatasertib, With Endocrine and CDK 4/6 Inhibitor for Patients With Metastatic Breast Cancer (TAKTIC)

This research is looking to find out if the combination of Ipatasertib with Aromatase inhibitor or Fulvestrant can be an effective treatment for breast cancer.

estrogen
cancer treatment
hormone therapy
endocrine therapy
stage iv breast cancer
  • 6 views
  • 12 Feb, 2022
  • 1 location
Ipatasertib and Docetaxel in Metastatic NSCLC Patients Who Have Failed 1st Line Immunotherapy

effective strategy. Ipatasertib is a novel adenosine triphosphate (ATP)-competitive inhibitor that has demonstrated robust and selective targeting of protein kinase B (PKB, also known as AKT) in cancer

  • 0 views
  • 08 Dec, 2021
  • 5 locations
Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal Cancer

Esophageal cancer, which has a low 5-year overall survival rate for all stages (<20%) , is increasing in incidence. Previous studies have shown that the Hedgehog (Hh) and AKT signaling

cancer
AKT
esophageal cancer
chemoradiotherapy
adjuvant therapy
  • 2 views
  • 12 Feb, 2022
  • 1 location
Efficacy and Safety of Sirolimus in Vascular Anomalies That Are Refractory to Standard Care

The phosphatidylinositol 3-kinase (PI3Kinase)/Protein Kinase B (AKT)/mammalian target of rapamycin (mTor) pathway plays a role on the development and the venous/lymphatic vascular organisations

  • 0 views
  • 21 Jan, 2021
  • 5 locations
Testing the Addition of an Anti-cancer Drug, Ipatasertib, to the Usual Immunotherapy Treatment (Pembrolizumab) in Patients With Recurrent or Metastatic Squamous Cell Cancer of the Head and Neck

neck that has come back (recurrent) or has spread to other places in the body (metastatic). Ipatasertib is in a class of medications called protein kinase B (AKT) inhibitors. It may stop the growth of

  • 0 views
  • 23 Jul, 2022
  • 1 location
Neoadjuvant Ontruzant (SB3) in Patients With HER2-positive Early Breast Cancer: An Open-Label (NeoON)

studies with CTX+ trastuzumab and with CTX+ pertuzumab. The efficacy is dependent on a variety of mechanisms including the blocking of the important PI3K/Akt and MAPK pathways, and ADCC (antibody

core needle biopsy
mammogram
her2/neu-positive breast cancer
HER2
measurable disease
  • 0 views
  • 12 Sep, 2021
  • 11 locations
Prognostic Value of Circulating Tumoral DNA After the First 6 Months of Treatment in Patients With Waldenstr m Macroglobulinemia

activation of NFkB and BTK in case of MYD88(L265P) mutation), the BCR pathway (involving btk and associated with activations of both NFkB, and erk akt pathway) and the CXCR4 pathway (CXCR4 is a receptor of

immunoglobulin
monoclonal antibodies
cytopenia
monoclonal antibody therapy
monoclonal protein
  • 0 views
  • 29 May, 2021
  • 1 location
HMB Enriched Amino Acids to Reverse Muscle Loss in Cirrhosis

factor) , phospho-Akt, phospho-AMPK (activated protein kinase), phospho-mTOR and phospho-p70s6k will be quantified by Western immunoblots. Autophagy flux will be measured by quantifying expression of the

insulin
amino acids
leucine
  • 0 views
  • 31 Dec, 2021
  • 1 location
Onabotulinum Toxin A in Direct Brow Lift

mechanisms include increased apoptosis and suppressed proliferation of fibroblasts treated with botulinum toxin, modulated via the PTEN/PI3K/Akt pathway. Park et al added to the in vitro literature by

  • 0 views
  • 03 Feb, 2021
  • 1 location