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Found 42 clinical trials
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Pilot Study of Topical Dexamethasone 0.01% Solution for Prevention of Oral Chronic Graft Versus Host Disease

at each visit). Review of medications (at each visit). ACTH stimulation test to evaluate adrenal gland function (at 3 months). Patients are given an injection of a drug called "ACTH

graft versus host disease
graft-versus-host disease
  • 38 views
  • 22 Dec, 2020
  • 1 location
featured
A Phase 2 Double-Blind, Placebo Controlled Multi-Center Study to Evaluate the Efficacy and Safety of Tcelna in Subjects With Secondary Progressive Multiple Sclerosis

A Phase 2 Double-Blind, Placebo Controlled Multi-Center Study to Evaluate the Efficacy and Safety of Tcelna in Subjects With Secondary Progressive Multiple Sclerosis

  • 204 views
  • 08 Nov, 2020
  • 1 location
Cortisol Response to Adrenocorticotrophin (ACTH) in Acute Stress

Cortisol deficiency is diagnosed by the adrenocorticotrophin (ACTH) stimulation test. This test measures cortisol levels in the blood before and after giving an injection of ACTH

open repair
aortic aneurysm
  • 58 views
  • 07 Nov, 2020
  • 1 location
A Clinical Study to Evaluate the Potential Role of ACTH Gel in Patients With Scleritis

ATLAS study is a clinical trial to evaluate the potential role of subcutaneous adrenocorticotropic hormone (ACTH) gel in the management of non-infectious scleritis. Specifically, the

  • 1 views
  • 16 Aug, 2021
  • 5 locations
Adrenocorticotropic Hormone (ACTH) for Post-op Inflammation in Proliferative Vitreoretinopathy (PVR)

-operative proliferative vitreoretinopathy patients receiving subcutaneous injections of H.P. Acthar, an adrenocorticotropic hormone (ACTH) analog. The study will be conducted at the Wilmer Eye Institute

  • 0 views
  • 22 Sep, 2021
  • 1 location
Evaluation of the Modified Atkins Diet in Children With Epileptic Spasms

Epileptic spasms are a difficult to treat epileptic condition in young children. The first line treatment is hormonal treatment, in the form of ACTH or oral steroids, which are effective in 60

  • 0 views
  • 22 Jan, 2021
  • 1 location
Preoperative Bexarotene Treatment for Cushing's Disease

The objective of this pilot study is to establish the safety and tolerability of short-term therapy with bexarotene in patient's with Cushing's disease, and study the clinical, biochemical, and cellular effects of a preoperative five-day course of bexarotene in these patients before undergoing transsphenoidal surgery.

hypercortisolism
inferior petrosal sinus sampling
urinary free cortisol
cushing's syndrome
ACTH
  • 42 views
  • 07 Nov, 2020
  • 1 location
Single and Multiple Ascending Dose Study of CORT125329 in Healthy Participants

The purpose of this study is to evaluate the dose-related safety, tolerability, pharmacokinetics (PK) and pharmacological effects (PD) of CORT125329 after single and multiple ascending oral doses of CORT125329 lipid capsule formulations in healthy participants.

  • 0 views
  • 06 Aug, 2021
  • 1 location
Adrenalectomy Versus Follow-up in Patients With Subclinical Cushings Syndrome

Incidental findings of adrenal tumours,"incidentalomas", occur in 1-5 % in the general population and 10-25 % of these patients will exhibit biochemical mild hypercortisolism. Although the patients do not have clinical signs of classical Cushing's syndrome, they have an increased risk for hypertension, dyslipidemia, diabetes mellitus, osteoporosis and obesity. The …

  • 2 views
  • 23 Sep, 2021
  • 8 locations
Phase I Study of AZD5363 + Olaparib + Durvalumab in Patients With Advanced or Metastatic Solid Tumor Malignancies

This is a Phase 1 dose-escalation study to evaluate the safety and tolerability of combination treatment of AZD5363 + Olaparib + Durvalumab and to determine the RP2D in patients with advanced or metastatic solid tumor malignancies. The purpose of this trial is to determine if combination treatment of drugs, Olaparib, …

  • 0 views
  • 22 Jan, 2021
  • 1 location