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Found 6 clinical trials
Study of the Safety and Efficacy of OMS721 in Patients With Immunoglobulin A (IgA) Nephropathy

The purpose of this study is to evaluate the safety and efficacy of OMS721 in patients with IgA nephropathy. The study will assess proteinuria by 24-hour urine protein excretion (UPE) in g/day

glomerular filtration rate
immunoglobulin a
  • 03 Jun, 2019
  • 29 locations
Reduction or Discontinuation of CNI's With Conversion to Everolimus-Based Immunosuppresion

This study is design to compare two different strategies aiming to lessen the degree of the ongoing process of allograft injury either by removing tacrolimus from the maintenance immunosuppressive protocol or by reducing tacrolimus dose. The primary goal is to assess the change in renal function at 6 and 12 …

immunosuppressive agents
renal impairment
kidney biopsy
  • 07 Nov, 2020
  • 1 location
A Crossover Pilot Study of the Effect of Amiloride on Proteinuria

This cross-over study is designed to test the hypothesis that amiloride will reduce urinary protein excretion and protect the kidney from rapid progression in proteinuric kidney disease.

glomerular filtration rate
  • 09 Feb, 2020
  • 2 locations
Standard 24-hour Urine Protein vs Shorter Period for Diagnosis of Pre-eclampsia

Background and project rationale: Preeclampsia is a common complication of pregnancy, affecting 6-8% of all pregnancies and constitutes a leading cause of maternal morbidity and mortality. Preeclampsia is liable to endanger the lives of both the gravida and the fetus, particularly if treatment is initiated inappropriately or in an untimely …

pregnancy complication
toxemia of pregnancy
  • 08 Nov, 2020
  • 1 location
Early Screening and Diagnosis of CKD

detect thrice albumin-creatinine ratio (ACR) within three months, with simultaneous test of urinary protein-creatinine ratio (PCR), 24-hour urine protein excretion rate (PER) and 24-hour albumin albumin

glomerular filtration rate
cystatin c
  • 23 Mar, 2020
  • 1 location
Experience With H.P. Acthar Gel Treatment of Patients With Nephrotic Syndrome/Proteinuria Due to Various Etiologies and Its Effect on Podocyte Function

Patients with proteinuria to start treatment with Acthar and watch a variety of clinical parameters with a goal of decreasing proteinuria between 50-100% over a period of nine months with every 3 months increasing the dose of medication until a decrease of either 50- 100 % of protein excretion is …

  • 10 Feb, 2020
  • 1 location