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Found 7 clinical trials
131I-MIBG With Myeloablative Chemotherapy and Autologous Stem Cell Transplantation for the Treatment of High-risk Neuroblastoma

This trial is studying how well iodine I 131 metaiodobenzylguanidine together with combination chemotherapy works in treating patients who are undergoing an autologous peripheral stem cell for high risk or relapsed neuroblastoma.

combination chemotherapy
catecholamines
recurrent neuroblastoma
stem cell transplantation
tumor cells
  • 8 views
  • 07 Nov, 2020
  • 2 locations
Evaluation of 2 Intensification Treatment Strategies for Neuroblastoma Patients With a Poor Response to Induction

The main objective is to evaluate the efficacy of two intensified consolidation strategies in very-high risk neuroblastoma (VHR-NBL) patients in terms of event-free survival from randomisation date. This evaluation will follow a hierarchical testing procedure: each experimental treatment will be first evaluated as a single-arm phase 2 study, and in …

  • 1 views
  • 11 Jun, 2021
  • 2 locations
Iobenguane I-131 or Crizotinib and Standard Therapy in Treating Younger Patients With Newly-Diagnosed High-Risk Neuroblastoma or Ganglioneuroblastoma

This phase III trial studies iobenguane I-131 or crizotinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Crizotinib may stop the growth of tumor cells by blocking …

stem cell transplantation
dinutuximab
melphalan
bone marrow procedure
etoposide
  • 66 views
  • 29 Jul, 2021
  • 104 locations
A Study of Therapeutic Iobenguane (131-I) and Vorinostat for Recurrent or Progressive High-Risk Neuroblastoma Subjects

The purpose of this study is to evaluate the efficacy and safety of 131I-MIBG in combination with Vorinostat in patients with Recurrent or Progressive neuroblastoma

karnofsky performance status
stem cell transplantation
melphalan
platelet transfusions
bone marrow procedure
  • 58 views
  • 10 Jun, 2021
  • 15 locations
MIBG With Dinutuximab +/- Vorinostat

131I-Metaiodobenzylguanidine (131I-MIBG) is one of the most effective therapies utilized for neuroblastoma patients with refractory or relapsed disease. In this pediatric phase 1 trial, 131I

catecholamines
monoclonal antibody ch14.18
monoclonal antibodies
cancer
tumor cells
  • 38 views
  • 29 Jan, 2021
  • 11 locations
MIBG for Refractory Neuroblastoma and Pheochromocytoma

This is a best available therapy/compassionate use single institution study designed to determine the palliative benefit and toxicity of 131I-MIBG in patients with progressive neuroblastoma and

catecholamines
myelosuppressive chemotherapy
g-csf
monoclonal antibodies
ejection fraction
  • 5 views
  • 29 Jan, 2021
  • 1 location
Patients Who Receive 131 I-MIBG

This study is for patients who have have neuroblastoma, pheochromocytoma, or paraganglioma that has come back (relapsed) after treatment or has not gotten better (refractory) with standard treatment. The purpose of this study is to evaluate quality of life and response rate to 131 I-MIBG treatment.

  • 0 views
  • 02 Jun, 2021
  • 1 location