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Found 29 clinical trials
MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic Function

, with screening including a physical examination including a 12-lead electrocardiogram (ECG) and questions about mental and physical health. Participants who meet study criteria will stay at the study

12 lead ECG
moderate hepatic insufficiency
drugs of abuse
alcohol test
  • 28 Feb, 2021
  • 1 location
ZIP Study - A Study to Evaluate the PK Safety Efficacy and PD With ATB200/AT2221 in LOPD Subjects Aged 12 to <18

This is a Phase 3, open-label, uncontrolled, multicenter study to evaluate the PK, safety, efficacy, and PD of ATB200/AT2221 treatment in pediatric subjects aged 12 to < 18 years with LOPD. Enzyme replacement therapy (ERT)-experienced subjects are those who have received at least 1 dose of alglucosidase alfa prior to …

replacement therapy
alglucosidase alfa
  • 25 Jan, 2021
  • 10 locations
Prevalence of Myocardial Scars on CMR After COVID-19 Infection

The aim of this study is to assess the prevalence and arrhythmogenic role of occult myocardial scars on Cardiac Magnetic Resonance (CMR) in a population of patients with history of laboratory-proven symptomatic COVID-19 infection managed without hospitalization, as compared to a population of age- and sex-matched healthy volunteers.

  • 26 Jan, 2021
  • 1 location
Cryoballoon vs. Rhythmia Guided Ablation for Recurrent AFib

The purpose of this research is to evaluate whether cryoballoon ablation vs. radiofrequency ablation guided by high-fidelity mapping (Rhythmia) is the best treatment strategy to perform repeat ablation for recurrent atrial fibrillation after previously having undergone cryoballoon ablation.

recurrent atrial fibrillation
12 lead ECG
radiofrequency ablation
  • 07 Apr, 2021
  • 3 locations
The Innate Central Nervous System Immune Response to an Experimental Immune Challenge in People With Fibromyalgia

The major goal of this study is to determine if the innate immune response is dysregulated in people with fibromyalgia, compared to healthy controls. Magnetic resonance spectroscopy will be used to measure changes in the brain's metabolic profile following an experimental immune stimulus, to test whether individuals with fibromyalgia show …

chronic pain
  • 25 Jan, 2021
  • 1 location
Zr-Df-IAB22M2C (CD8 PET Tracer) for PET/CT in Patients With Metastatic Solid Tumors

Protocol IAB-CD8-201 is a Phase II, Open Label, Multi-Dose Study of Zr-Df-IAB22M2C (CD8 PET Tracer) for Positron Emission Tomography (PET/CT) in Patients with Advanced or Metastatic Melanoma, Non-Small Cell Lung Cancer, Renal Cell Carcinoma, Squamous Cell Carcinoma of the Head and Neck Selected to Receive Standard-of-Care Immunotherapy as Single Agent …

  • 23 Jan, 2021
  • 9 locations
Siltuximab in Schizophrenia

This study is a Phase 1 clinical trial to determine the safety, tolerability, and efficacy of Siltuximab (Sylvant) as an adjunct to antipsychotic medications in stable outpatients with schizophrenia. Siltuximab (structural formula C6450H9932N1688O2016S50) is a recombinant chimeric (human-murine) anti-human interleukin-6 (IL-6) monoclonal antibody. Siltuximab is formulated as a concentrate for …

adjunctive treatment
psychotropic drugs
schizoaffective disorder
  • 24 Jan, 2021
  • 1 location
Exercise Induced QT Interval Changes in Response to Intermittent and Continuous Graded Exercise Tests

Long QT syndrome (LQTS) is an inherited heart defect where the heart takes longer to recover between beats. LQTS is a known condition predisposing young footballers to sudden cardiac death (SDC). The existence of LQTS can be established by measuring the QT interval in an electrocardiogram (ECG). Currently pre-participation cardiac …

  • 25 Jan, 2021
  • 1 location
Acute Exposure to Diesel: Prolong Effects on Inflammation and Vasculature

Cross-over double-blind study. Healthy subjects will be exposed to diesel exhaust fumes and/or filtered air during a 2-hour session. Several parameters will be assesed i.e. endothelial function will be assessed with flow mediated dilation (FMD) techniques, arterial stiffness with pulse wave velocity (PWV) and reflected waves with augmentation index (AIx). …

  • 23 Jan, 2021
  • 2 locations
CF Bronchodilation

It is estimated that one in every 3,600 children in Canada has cystic fibrosis (CF). CF is a genetic disease that affects the glands that produce mucus and sweat. In CF, mucus production increases and the mucus becomes thick and sticky. This can block the airways, making it difficult to …

genetic disorder
  • 26 Jan, 2021
  • 1 location