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Found 61 clinical trials
The Effect of Low LEVel TrAgus STimulation on the Electrophysiological Substrate of Patients With Ischemic CardioMyopathy Substrate of Subjects With Ischemic CardioMyopathy

5Hz (15min) and 20Hz (15min). The latter is required to examine the effect of LLTS on RA independent of heart rate. Repolarization alternans will be measured by analyzing a regular 12-lead ECG using a

heart failure
ejection fraction
  • 17 views
  • 30 Apr, 2021
  • 1 location
Epicardial Ablation in Brugada Syndrome. An Extension Study of 500 BrS.Patients

This study represents an extension of a previous study (NCT02641431) on the acute and long-term benefit of epicardial ablation on elimination of both BrS-ECG pattern and VT/VF inducibility in 500 consecutive BrS patients.

  • 8 views
  • 26 Jan, 2021
  • 1 location
Acute Haemodynamic Study of TPN171H in Patients With Pulmonary Arterial Hypertension

This study is a phase IIa proof-of-concept study to evaluate the effect of single-dose TPN171H tablets on acute haemodynamic parameters in patients with pulmonary arterial hypertension.The trial is expected to include 60 patients, divided into 6 groups, according to 1:1:1:1:1:1 into the placebo group and the test drugs 2.5mg, 5mg, …

heart disease
hypertension
tadalafil
connective tissue disease
  • 0 views
  • 27 Jan, 2021
  • 6 locations
CLOSE Versus High Density Mapping Guided Catheter Ablation of Paroxysmal Atrial Fibrillation

The aim of this study is to compare two methods of catheter ablation for treatment of paroxysmal atrial fibrillation (AF). The first method being a modified CLOSE protocol used for the control group and the second high density mapping guided isolation of pulmonary veins used for the interventional group. Comparison …

  • 0 views
  • 09 Mar, 2021
  • 1 location
Effect of Estetrol Monohydrate (E4) on QTc Interval

The purpose of this study is: to evaluate if E4 has any effect on how the heart beats when a single dose is given at two different dose levels; to determine the ability to detect small changes in how the heart beats using a positive control: moxifloxacin, a quinolone antibiotic …

  • 0 views
  • 04 Apr, 2021
  • 1 location
CFAE/Spatiotemporal Dispersion Guided Ablation Versus PVI Guided Ablation in Persistent AF

Objective: The purpose of this study is to compare the efficacy and safety of ablation of Atrial Fibrillation (AF) drivers marked by spatiotemporal dispersions and Complex Fractionated Atrial Electrocardiograms (CFAEs) to Pulmonary Vein Isolation (PVI) based ablation in patients with persistent AF. Hypothesis: CFAE/spatiotemporal dispersion guided ablation will increase AF …

  • 0 views
  • 25 Jan, 2021
  • 4 locations
Efficacy Safety Tolerability and Biomarkers of MN-166 (Ibudilast) in Patients Hospitalized With COVID-19 and at Risk for ARDS

The study aims to evaluate MN-166 (ibudilast) in patients with COVID-19 who are at risk of developing acute respiratory distress syndrome. Subjects will be screened, randomly assigned to MN-166 or placebo groups, receive study drug on Days 1-7, and followed up on Day 14 and Day 28.

  • 0 views
  • 04 Mar, 2021
  • 2 locations
A Phase I Gene Therapy Study of FP253/Fludarabine for Prostate Cancer

The primary objective of this study is to determine the safety and tolerability of a gene-directed enzyme prodrug therapy for prostate cancer. FP253 contains an ovine atadenovirus that expresses the E. coli enzyme purine nucleoside phosphorylase (PNP) under the control of a prostate-directed promoter. PNP converts systemically administered fludarabine (the …

androgen suppression
adenocarcinoma of prostate
biopsy of prostate
androgens
orchiectomy
  • 90 views
  • 07 Nov, 2020
  • 1 location
Biventricular Pacing in Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy is an inherited condition characterized by thickening (hypertrophy) of the heart muscle. Many patients who have this condition have a reduced ability to exercise because of breatlessness, which can in some cases be severe. This appears in most cases to be due to an impairment of the filling …

hypertrophy
heart failure
  • 88 views
  • 07 Nov, 2020
  • 1 location
EVALECGcardio Study

obviating the need for a full 12 lead ECG. This may allow for earlier diagnosis and treatment.

12 lead ECG
arrhythmia
electrocardiogram
  • 0 views
  • 24 Jan, 2021
  • 1 location