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Found 57 clinical trials
B010-A Injection for Treating Patients With GPC3 Positive Advanced Hepatocellular Carcinoma

This is an Open-label, Single Arm study to observe the safety and tolerability of B010-A in the treatment of advanced hepatocellular carcinoma.

  • 03 Jan, 2022
  • 1 location
Epicardial Ablation in Brugada Syndrome. An Extension Study of 500 BrS.Patients

This study represents an extension of a previous study (NCT02641431) on the acute and long-term benefit of epicardial ablation on elimination of both BrS-ECG pattern and VT/VF inducibility in 500 consecutive BrS patients.

  • 25 Feb, 2022
  • 1 location
Acute Haemodynamic Study of TPN171H in Patients With Pulmonary Arterial Hypertension

This study is a phase IIa proof-of-concept study to evaluate the effect of single-dose TPN171H tablets on acute haemodynamic parameters in patients with pulmonary arterial hypertension.The trial is expected to include 60 patients, divided into 6 groups, according to 1:1:1:1:1:1 into the placebo group and the test drugs 2.5mg, 5mg, …

heart disease
connective tissue disease
  • 29 Dec, 2021
  • 9 locations
CLOSE Versus High Density Mapping Guided Catheter Ablation of Paroxysmal Atrial Fibrillation

The aim of this study is to compare two methods of catheter ablation for treatment of paroxysmal atrial fibrillation (AF). The first method being a modified CLOSE protocol used for the control group and the second high density mapping guided isolation of pulmonary veins used for the interventional group. Comparison …

  • 09 Mar, 2021
  • 1 location
Clinical Trials of Multivalent Opioid Vaccine Components

Currently, abuse of prescription opioid analgesics and heroin is a serious problem in the U.S. Although several medications, including methadone, buprenorphine, and naltrexone, are available and effective in treating opioid use disorder (OUD), long-term relapse rates remain high. The current study is designed to examine a new approach to treating …

  • 05 Jul, 2021
The Effect of Intra Operative Dexmedetomidine in Prevention of Early Postoperative Atrial Fibrillation

The incidence of atrial fibrillation (AF) after lung resection varies between 12% and 30% after lobectomy and 23%-67% after pneumonectomy. The average time of onset of AF after lung resection is 2-3 days. AF after pulmonary resection can cause symptoms, hemodynamic instability, and stroke.Furthermore, AF following pulmonary resection may triple …

Accepts healthy volunteers
  • 30 Apr, 2022
  • 1 location
Bariatric Atrial Restoration of Sinus Rhythm (BAROS)

The objective of this study is to determine whether bariatric surgery followed by Atrial Fibrillation (AF) catheter ablation is superior to AF catheter ablation alone in the management of atrial fibrillation in patients with morbid obesity.

paroxysmal atrial fibrillation
bariatric surgery
antiarrhythmic drug
  • 03 Mar, 2022
  • 1 location
Evaluation of MRI-conditional 12-lead ECG

medical device company, has developed a high-fidelity, MRI-conditional 12-lead ECG monitoring system. This 12-lead ECG system is a first of its kind that addresses the MRI-induced interference and safety

  • 27 Mar, 2021
  • 1 location
Diagnostic Accuracy of WEARable TECHnology Single-lead ECG in Detecting Cardiac Arrhythmias (WEAR-TECH ECG)

placed on the skin to record the heart's electrical activity. A 12-lead ECG uses 10 sensors and is the gold-standard (best available test) to detect any abnormal heart rhythm disturbances. Until recently

Accepts healthy volunteers
  • 11 May, 2022
  • 1 location
VaLidation of the Simple Adaptation of the Kardia 6L ECG Recorder to Obtain Chest leAd equivaLents: a Multi-centre International (LOCAL-ECG) Study; on Behalf of the Africa Heart Rhythm Association Investigators (LOCAL-ECG)

, thereby obviating the need for a full 12 lead ECG. This may allow for earlier diagnosis and treatment and has implications in the prevention of infection. The lead author recently published a

Accepts healthy volunteers
  • 24 Apr, 2022
  • 1 location