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Found 198 clinical trials
Daily Vitamin D for Sickle-cell Respiratory Complications (ViDAS-2)

This study aims to answer the question whether daily oral vitamin D supplementation can reduce the risk of respiratory or lung complications in children and adolescents with sickle cell disease. Respiratory problems are the leading causes of sickness and of death in sickle cell disease. The investigators hypothesize that daily …

hb s
vitamin d supplementation
vitamin d
thalassemia
cholecalciferol
  • 1 views
  • 15 Jul, 2022
  • 1 location
Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants

Background Blood disorders like sickle cell disease and malaria affect many people around the world. Researchers want to learn more about blood disorders. To do this, they need to collect biological samples from people with blood disorders. They also need to collect samples from healthy people. Objective To collect samples …

anemia
Accepts healthy volunteers
malaria
x-rays
alpha globin
  • 81 views
  • 21 Jul, 2022
  • 1 location
Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies

This is a single arm pilot study of peripheral stem cell transplantation (PSCT) with ex vivo t-cell receptor alpha beta+(TCRαβ+) T cell and cluster of differentiation 19+ beta (CD19+ B) cell depletion of unrelated donor (URD) grafts using the CliniMACS device in patients with sickle cell disease (SCD) and beta …

hemoglobinopathy
thalassemia
blood transfusion
hemoglobin ss
cell transplantation
  • 0 views
  • 25 Mar, 2022
  • 1 location
Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia

Background Sickle cell disease (SCD) is an inherited disorder of the blood. It can damage a person s organs and cause serious illness and death. A blood stem cell transplant is the only potential cure for SCD. Treatments that improve survival rates are needed. Objective To find out if a …

Accepts healthy volunteers
thalassemia
cell transplantation
hydroxyurea
sirolimus
  • 0 views
  • 27 Jul, 2022
  • 1 location
Observing the Changes of Endocrine and Metabolism in Patients With Thalassemia Major

Patient with thalassemia major have many endocrine diseases, such as hypopituitarism, hypothyroidism, hypoparathyroidis, osteoporosis, and etc.. These problems may be due to anemia itself or related to iron deposition. This study aimed to investigate the endocrine aspect of thalassemia major patients in Taiwan in order to introduce early intervention or …

anemia
osteoporosis
iron
  • 0 views
  • 07 Feb, 2022
  • 1 location
Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical Study

The only curative therapy for thalassemia major remains the replacement of the defective erythropoiesis by allogeneic hematopoietic stem cell transplantation(allo-HSCT). We conduct a prospective multicenter study to evaluate the efficacy of allo-HSCT in the treatment of thalassemia major.

ineffective erythropoiesis
ejection fraction
mycophenolate mofetil
stem cell transplantation
cell transplantation
  • 17 views
  • 11 Feb, 2022
  • 1 location
L-Glutamine Therapy for Sickle Cell Anemia

This is a study to determine the efficacy of L-glutamine as therapy for sickle cell anemia and sickle O-thalassemia.

anemia
glutamine
thalassemia
  • 86 views
  • 07 Nov, 2020
  • 1 location
Effect of Exercise on Biomarkers in SCT

This study measures the effect of exercise on a variety of biomarkers in blood and urine selected to evaluate the physiological pathways of hemolysis, myolysis, thrombosis, inflammation, and renal function in subjects with sickle cell trait. These pathways have been shown to be associated with adverse events in athletes and …

Accepts healthy volunteers
sickle cell trait
hemolysis
  • 0 views
  • 22 Mar, 2022
  • 1 location
International Registry of Patients With Alpha Thalassemia

This is an international prospective registry of patients with Alpha thalassemia to understand the natural history of the disease and the outcomes of fetal therapies, with the overall goal of improving the prenatal management of patients with Alpha thalassemia.

ATM
alpha-thalassemia
cell transplantation
  • 0 views
  • 10 Oct, 2021
  • 1 location
Evaluation of Heart Status in Patients of Beta Thalassemia Using Echocardiogram

Heart failure from myocardial iron deposition is a severe complication for patients with transfusion-dependent beta thalassemia . Increased cardiac iron content impacts the contractility of cardiomyocytes and can also lead to myocarditis, pericarditis, and arrhythmias. The severity of cardiac dysfunction depends on the amount of iron deposited in the myocardium.Echocardiogram …

iron
beta thalassemia
  • 0 views
  • 26 Jun, 2021
  • 1 location