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North Chesterfield, Virginia Clinical Trials

A listing of North Chesterfield, Virginia clinical trials actively recruiting patient volunteers.

RESULTS

Found (15) clinical trials

Safety Tolerability and Pharmacodynamics of SYNB1020

This study consists of two parts: Part 1 (Completed): A sentinel open-label cohort of subjects with cirrhosis and Model for End-Stage Liver Disease (MELD) score <12 will be admitted to an inpatient facility for a run in diet, baseline assessments, IP administration, safety monitoring, and collection of blood, urine, and ...

Phase

2.69 miles

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FMT in Cirrhosis and Hepatic Encephalopathy

Indication: Cirrhosis and hepatic encephalopathy Study Objectives: To evaluate the safety and tolerability of fecal transplant in patients with cirrhosis and hepatic encephalopathy Rationale and Supporting Evidence: Hepatic encephalopathy affects 30-45% of patients with cirrhosis and adversely affects survival in these patients. The mainstay of treatment for hepatic encephalopathy (HE) ...

Phase

4.7 miles

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Study Evaluating Safety and Efficacy of JCAR017 in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)

This is a Phase 1/2, open-label, multicenter study to determine the efficacy and safety of JCAR017 in adult subjects with relapsed or refractory CLL or SLL. The study will include a Phase 1 part to determine the recommended dose of JCAR017 monotherapy in subjects with relapsed or refractory CLL or ...

Phase

5.99 miles

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Phase 1-2 Study of ASTX660 in Subjects With Advanced Solid Tumors and Lymphomas

ASTX660 is a synthetic small molecule dual antagonist of cellular inhibitor of apoptosis protein (cIAP) 1 and X-linked inhibitor of apoptosis protein (XIAP) that has been shown to have potent proapoptotic and tumor growth inhibitory activity in nonclinical models. ASTX660 has not been previously evaluated in human subjects. The Phase ...

Phase

5.99 miles

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Study of ProTmune for Allogeneic HCT in Adult Patients With Hematologic Malignancies

This study is a Phase 1, Non-randomized, Open-label/Phase 2 Randomized, Blinded Study of ProTmune (ex vivo programmed mobilized peripheral blood cells) Versus Non-programmed mobilized peripheral blood cells for Allogeneic Hematopoietic Cell Transplantation (HCT) in Adult Subjects Aged 18 years and older with Hematologic Malignancies. A maximum of 70 total eligible ...

Phase

5.99 miles

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Initial Feasibility Study to Treat Borderline Resectable Pancreatic Cancer With a Planar LDR Source

This is a Feasibility study to determine the safety and efficacy of a new brachytherapy device that provides unidirectional radiation which utilizes active components (Palladium-103) of standard devices in a novel configuration.This pilot study may benefit pancreatic cancer patients by reducing the radiation dose to adjacent critical structures, while giving ...

Phase

5.99 miles

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Effects of Liothyronine on Energy Expenditure and Cardiovascular Function

This study will assess the short term effects of a single dose of liothyronine on the cardiovascular system and energy expenditure

Phase

5.99 miles

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5HT2CR Balance in Brain Connectivity in Cocaine Dependence

The overall goal of this project is to evaluate the role of molecular interactions between 5-HT2AR and 5-HT2CR in behavioral phenotypes that confer risk for cocaine dependence and relapse. Specifically, this project will evaluate the role of the 5-HT2CR:5-HT2AR balance in impulsive action and cue reactivity in cocaine-dependent subjects as ...

Phase

5.99 miles

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Neratinib + Valproate in Advanced Solid Tumors w/Expansion Cohort in Ras-Mutated Ca

This study is a single-arm, open-label, phase 1/2 trial to determine the recommended phase 2 dose of neratinib and sodium valproate when given in combination to patients with advanced solid tumors in 28 day cycles. The phase II portion of the study will evaluate the combination at the RP2D in ...

Phase

5.99 miles

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A Gene Transfer Study for Hemophilia A

Hemophilia A is a condition in which blood is unable to clot effectively. It is caused by a mutation or deletion in the gene that is responsible for producing blood-clotting factor VIII protein. Individuals with hemophilia A suffer from repeated bleeding episodes, often into the joints, which can cause chronic ...

Phase

6.26 miles

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