Search Medical Condition
Please enter condition
Please choose location from dropdown
Clear Trial Filters
 

Falls Church, Virginia Clinical Trials

A listing of Falls Church, Virginia clinical trials actively recruiting patient volunteers.

RESULTS

Found (213) clinical trials

Title: Evaluation of a Novel PET Radioligand for Phosphodiesterase-4D (PDE4D)

Objective Phosphodiesterase type 4 (PDE4) metabolizes 3 <=,5 <=-cyclic adenosine monophosphate (cAMP), thereby terminating this second messenger. PDE4 is selective to cAMP over cyclic guanosine monophosphate. PDE4 has four isozymes A, B, C, and D and basic studies suggest that type D (PDE4D) may play a key role in cognitive ...

Phase

8.96 miles

Learn More »

HERV-K Suppression Using Antiretroviral Therapy in Volunteers With Amyotrophic Lateral Sclerosis (ALS)

Objective In this Phase I, proof-of-concept study, we aim to determine whether an antiretroviral regimen approved to treat human immunodeficiency virus (HIV) infection would also suppress levels of Human Endogenous Retrovirus-K (HERV-K) found to be activated in a subset of patients with amyotrophic lateral sclerosis (ALS). We propose to measure ...

Phase

8.96 miles

Learn More »

Interleukin-15 (IL-5) in Combination With Avelumab (Bavencio) in Relapsed/Refractory Mature T-cell Malignancies

Background -Mature T-cell cancers are a phenotypically heterogeneous group of malignancies which constitute 10-15% of all non-Hodgkin lymphomas (NHL). Patients with relapsed/refractory T cell lymphomas have limited therapeutic options, making new therapeutic approaches extremely important. -The immunologic effects of recombinant human Interleukin-15 (rhIL-15), a stimulatory cytokine that promotes the differentiation ...

Phase

8.96 miles

Learn More »

Investigation of Blood-Brain-Barrier Breakdown Using Manganese Magnetic Resonance Imaging in Drug-Resistant Epilepsy

Objective: The primary goals of this pilot study is to (1) describe the safety profile of administration of mangafodipir patients with epilepsy and (2) determine if peri-ictal administration will allow focal entry of mangafodipir through the blood-brain-barrier and manganese enhanced magnetic resonance imaging (MEMRI) visualization of seizure foci. Secondary objectives ...

Phase

8.96 miles

Learn More »

A Phase I/Ib Study of NIZ985 in Combination With PDR001 in Adults With Metastatic Cancers

Phase I/Ib multicenter clinical trial. Single agent dose escalation of NIZ985 followed by expansion. Second escalation of NIZ985 in combination with PDR001 followed by expansion

Phase

9.09 miles

Learn More »

Androgen Reduction in Congenital Adrenal Hyperplasia Phase 1

Congenital adrenal hyperplasia (CAH) is an inherited inability to synthesize cortisol in the adrenal gland. More than 90% of cases are cause by deficiency of steroid 21-hydroxylase (CYP21, also termed CYP21A2, P450c21), which is a cytochrome P450 enzyme located in the endoplasmic reticulum. It catalyzes conversion of 17-hydroxyprogesterone (17-OHP) to ...

Phase

9.09 miles

Learn More »

Enzastaurin and Carboplatin in Treating Patients With Recurrent or Refractory Primary Brain Tumors

OBJECTIVES: Primary - Determine the maximum tolerated dose of enzastaurin hydrochloride when administered with carboplatin in patients with recurrent or refractory primary brain tumors. - Determine the pharmacokinetics of this regimen in these patients. Secondary - Correlate clinical outcome with GSK3-b activation in peripheral blood mononuclear cells of patients treated ...

Phase

9.09 miles

Learn More »

MRI-Guided Radiation Therapy in Treating Patients With Prostate Cancer

OBJECTIVES: Primary - Determine the maximum tolerated dose of MRI-guided intensity-modulated external beam radiotherapy in patients with prostate cancer. Secondary - Correlate the radiation response to and/or toxicity of this regimen with genomic and proteomic analyses in these patients. - Determine the long-term effects and toxicity of this regimen after ...

Phase

9.09 miles

Learn More »

MRI-Guided Radiation Therapy in Treating Patients With Prostate Cancer

OBJECTIVES: - Determine the feasibility of treating the pelvic lymph nodes in patients with prostate cancer treated with intensity-modulated radiotherapy (IMRT). - Determine the maximum tolerated dose of IMRT in these patients. - Determine long term effects and toxicity in patients treated with IMRT. OUTLINE: This is a pilot, dose-escalation ...

Phase

9.09 miles

Learn More »

Sorafenib in Treating Patients With Kaposi's Sarcoma

OBJECTIVES: Primary - Assess the toxicity profile and pharmacokinetics of sorafenib in patients with HIV-related Kaposi's sarcoma (KS) who are receiving ritonavir. - Assess, in a preliminary manner, the pharmacokinetics and toxicity profile of sorafenib in patients with HIV-related or HIV-unrelated (classic) KS who are not receiving ritonavir. Secondary - ...

Phase

9.09 miles

Learn More »