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Falls Church, Virginia Clinical Trials

A listing of Falls Church, Virginia clinical trials actively recruiting patient volunteers.

RESULTS

Found (10) clinical trials

Dose-finding Study of GSK2636771 When Administered in Combination With Enzalutamide in Male Subjects With Metastatic Castration-Resistant Prostate Cancer

This Phase I, open-label, dose-finding, multicenter study is designed to determine the recommended Phase II dose (RP2D) for the combination of an orally administered Phosphatidylinositol-4,5-bisphosphate 3-kinase beta (PI3K-beta) inhibitor (GSK2636771) with enzalutamide. Subjects with phosphatase and tensin homolog (PTEN)-deficient metastatic castration-resistant prostate cancer (mCRPC) who are receiving a stable dose ...

Phase

5.66 miles

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Ascending Dose Study of Genome Editing by Zinc Finger Nuclease Therapeutic SB-FIX in Subjects With Severe Hemophilia B

The objective of the study is to provide long term expression of Factor IX in subjects with severe hemophilia B. SB-FIX is a therapeutic for ZFN-mediated genome editing which will be delivered by adeno-associated virus (AAV)-derived vectors. SB-FIX is intended to function by placement of a corrective copy of the ...

Phase

5.66 miles

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Highly Conformal Hypofractionated Focally Dose Escalated Post-Prostatectomy Radiotherapy

BACKGROUND Prostate cancer that recurs after prostatectomy (rising PSA) with no evidence of metastatic disease is often treated with radiation to the entire prostate bed to a dose of 66-72 Gy over 6-7 weeks. This treatment can provide PSA control in approximately 75% of patients, but may have associated genitourinary ...

Phase

8.96 miles

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Prostate SBRT for Locally Recurrent Prostate Cancer After Prior Radiotherapy

Background Prostate cancer that recurs after prior radiation treatment can be challenging to cure due to the side effects of available treatments such as surgery and cryoablation. Re-irradiation with brachytherapy or stereotactic approaches has shown excellent rates of prostate cancer disease control with tolerable side effects. Using image guidance to ...

Phase

8.96 miles

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A Phase 1 Study To Evaluate Escalating Doses Of A Vaccine-Based Immunotherapy Regimen For Prostate Cancer (PrCa VBIR)

The study will evaluate the safety, pharmacokinetics and pharmacodynamics of increasing doses of a vaccine-based immunotherapy regimen for patients with prostate cancer.

Phase

8.96 miles

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Study to Compare Capsule and Liquid Formulations of Enzalutamide After Single Dose Administration Under Fasting Conditions in Prostate Cancer

Background Enzalutamide is currently approved for the treatment of patients with mCRPC The marketed (reference) formulation of enzalutamide is a liquid-filled, soft gelatin capsule containing 40 mg enzalutamide dissolved in Labrasol; four such capsules are required to deliver a 160 mg dose The four-capsule regimen is inconvenient because of the ...

Phase

8.96 miles

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Neoantigen DNA Vaccine in Combination With Nivolumab/Ipilimumab and PROSTVAC in Metastatic Hormone-Sensitive Prostate Cancer

This study study aims to elucidate the immune responses to a shared antigen vaccine (PROSTVAC) and tumor specific antigens generated DNA vaccine in combination with checkpoint blockade using nivolumab (anti-PD-1), and ipilimumab (anti-CTLA-4). Additionally, the investigators will study the impact of the combination immunotherapy on peripheral T cell activation, as ...

Phase

8.96 miles

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Treatment of Castration Resistant Prostate Cancer Using Multi-Targeted Recombinant Ad5 PSA/MUC1/Brachyury Based Immunotherapy Vaccines

Background The overall goal of the current project is to expand our immunotherapeutic approach for the treatment of prostate cancer employing a multi-targeted approach. Therapeutic cancer vaccines targeting overexpressed proteins offer a potential method to activate T cells against tumors. A novel adenovirus based vaccines targeting three (3) human tumor ...

Phase

8.96 miles

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MRI-Guided Radiation Therapy in Treating Patients With Prostate Cancer

OBJECTIVES: Primary - Determine the maximum tolerated dose of MRI-guided intensity-modulated external beam radiotherapy in patients with prostate cancer. Secondary - Correlate the radiation response to and/or toxicity of this regimen with genomic and proteomic analyses in these patients. - Determine the long-term effects and toxicity of this regimen after ...

Phase

9.09 miles

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MRI-Guided Radiation Therapy in Treating Patients With Prostate Cancer

OBJECTIVES: - Determine the feasibility of treating the pelvic lymph nodes in patients with prostate cancer treated with intensity-modulated radiotherapy (IMRT). - Determine the maximum tolerated dose of IMRT in these patients. - Determine long term effects and toxicity in patients treated with IMRT. OUTLINE: This is a pilot, dose-escalation ...

Phase

9.09 miles

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