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Charlottesville, Virginia Clinical Trials

A listing of Charlottesville, Virginia clinical trials actively recruiting patient volunteers.

RESULTS

Found (15) clinical trials

Standardized Treatment of Pulmonary Exacerbations II

The study will assess the non-inferiority of 10 days versus 14 days treatment duration among patients who have an early robust improvement (ERR subjects) and the superiority of 21 days versus 14 days treatment duration among the subjects who do not meet the definition of ERR (non-ERR; NERR). Subjects will ...

Phase

5.55 miles

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Comparative Effectiveness Research Trial for Antidepressant Incomplete and Non-responders With TRD

This is a multi-site, randomized, open-label, effectiveness trial comparing three treatment arms for Major Depressive Disorder (MDD) patients with TRD who are currently on ongoing, stable and adequate antidepressant therapy (ADT). Adequate ADT is defined as a therapeutically sufficient dose for a sufficient treatment period, which would be expected to ...

Phase

5.55 miles

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Discontinuation of Disease Modifying Therapies (DMTs) in Multiple Sclerosis (MS)

Participants will be randomized to one of the 2 groups of research subjects. One of these groups will stay on their current MS medication, and one group will discontinue their medication. They will also have some extra assessments done at their regular routine MS clinic appointment and every 6 months ...

Phase

5.55 miles

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Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

PEPPER is a large pragmatic clinical trial to inform patient choice and balance risk tolerances of individuals who face decisions about different drugs and strategies for deep vein thrombosis (DVT) and pulmonary embolism (PE) prevention after total hip (THA) and knee (TKA) replacement. Indeed, clinical equipoise exists to ethically support ...

Phase

5.55 miles

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Study Tests Whether a Standardized LVR Performed With the Blue Egg Device Improves Cardiopulmonary Exercise Capacity

The primary objective of this study is to test whether a standardized Left Ventricular Reconstruction (LVR) performed with the Blue Egg device improves cardiopulmonary exercise capacity in subjects with stable New York Heart Association (NYHA) Class III or IV heart failure due to ischemic cardiomyopathy with an akinetic or dyskinetic ...

Phase

5.55 miles

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Trial of Alvimopan in Major Spine Surgery

Pain control following major spine surgery is difficult to achieve. Opiates are often necessary in high doses, and may be associated with significant side effects. Such side effects may include urinary retention, altered mental status, depressed respiratory drive, and constipation, and may lead to reduced nutritional intake in the postoperative ...

Phase

5.55 miles

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A Trial of Alirocumab and Plaque Regression in Peripheral Arterial Disease

PAD is characterized by lower limb arterial obstruction due to atherosclerosis. There are over 8.5 million people with PAD in the U.S. Recent data in a general population over 40 demonstrated an incidence of PAD defined by ankle brachial index (ABI) of 4.3%. Another study of over 3000 patients, mean ...

Phase

5.55 miles

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Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome

Health organizations recommend exercise in an intensity based manner to promote cardiovascular adaptation and prevent disease. Metformin is a common anti-diabetes medication that reduces future type 2 diabetes and cardiovascular disease (CVD) risk. However, the optimal dose of exercise to be combined with metformin for vascular health remains unknown. The ...

Phase

5.55 miles

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Antibiotic Prophylaxis in Patients Undergoing Elective TKA- Multi-center Trial

Total joint arthroplasty (TJA), is one of the most successful operations in modern medicine; however, it remains an expensive procedure in an era of constrained health care resources. Arthritis affects 49.9 million Americans with 21.1 million experiencing arthritis-attributable activity limitations. As these numbers are expected to increase significantly by 2030, ...

Phase

5.55 miles

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Pharmacokinetics of Single-Dose Liposomal Bupivacaine in Surgeon Performed Intercostal Nerve Blocks

In this study, patients who are undergoing thoracotomies will be consented separately from the surgery itself. Patients will be consented for the study in the surgical clinic or on the day of the surgery in the Surgical Admission Suites (SAS), prior to being taken to the OR. The study participants ...

Phase

5.55 miles

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