Cranston, Rhode Island Clinical Trials

A listing of Cranston, Rhode Island clinical trials actively recruiting patient volunteers.

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Found 96 clinical trials
A Phase 3 Efficacy Safety and Tolerability Study of Zolbetuximab (Experimental Drug) Plus mFOLFOX6 Chemotherapy Compared to Placebo Plus mFOLFOX6 as Treatment for Gastric and Gastroesophageal Junction (GEJ) Cancer

A study of zolbetuximab (IMAB362) plus mFOLFOX6 versus placebo plus mFOLFOX6 in subjects with Claudin 18.2 positive, HER2-negative, locally advanced unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma. Why is this study being done? SPOTLIGHT is a new clinical study for adult patients who have any of: advanced unresectable gastric …

Rhode Island Hospital-Lifespan Cancer Institute
 (3.1 away) Contact site
  • 485 views
  • 16 Sep, 2021
  • +239 other locations
Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors

This trial will study tisotumab vedotin to find out whether it is an effective treatment for certain solid tumors and what side effects (unwanted effects) may occur. There are three parts to this study. In Part A, the treatment will be given to participants every 3 weeks (3-week cycles). In …

systemic therapy
bevacizumab
kinase inhibitor
tyrosine
measurable disease
Rhode Island Hospital
 (3.1 away) Contact site
  • 226 views
  • 16 Sep, 2021
  • +48 other locations
An Induction Study of Mirikizumab in Participants With Moderately to Severely Active Ulcerative Colitis (LUCENT 1)

The purpose of this study is to evaluate the safety and efficacy of Mirikizumab in participants with moderately to severely active ulcerative colitis (UC) who have had an inadequate response to, loss of response, or intolerant to conventional or biologic therapy for UC.

mirikizumab
Ocean State Clinical Research Partners
 (9.2 away) Contact site
  • 1731 views
  • 12 Sep, 2021
  • +880 other locations
Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming …

tamoxifen
erbb2
immunostimulant
carcinoma
aromatase inhibitor
Women and Infants Hospital
 (2.4 away) Contact site
  • 598 views
  • 15 Sep, 2021
  • +318 other locations
Comparing an Operation to Monitoring With or Without Endocrine Therapy (COMET) Trial For Low Risk DCIS

This study looks at the risks and benefits of active monitoring (AM) compared to surgery in the setting of a pragmatic prospective randomized trial for low risk DCIS. Our overarching hypothesis is that management of low-risk Ductal Carcinoma in Situ (DCIS) using an AM approach does not yield inferior cancer …

invasive cancer
cancer
erbb2
hormone therapy
mammogram
Rhode Island Hospital
 (5.0 away) Contact site
  • 1212 views
  • 03 Sep, 2021
  • +136 other locations
Comparative Effectiveness of Pulmonary Embolism Prevention After Hip and Knee Replacement

PEPPER is a randomized study comparing the three most commonly used anticoagulants in North America in patients who have elected to undergo primary or revision hip or knee joint replacement surgery. The anticoagulants being compared are enteric coated aspirin, low intensity warfarin, and rivaroxaban.

embolism
rivaroxaban
total knee replacement
anticoagulants
aspirin
Lifespan Health
 (4.7 away) Contact site
  • 324 views
  • 03 Sep, 2021
  • +34 other locations
Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction

The primary objective of Part 1 of the study is to determine if BIIB093 improves functional outcome at Day 90 as measured by the modified Rankin Scale (mRS) when compared with placebo in participants with Large Hemispheric Infarction (LHI). The secondary objectives of Part 1 of the study are to …

ischemic stroke
glibenclamide
infarct
stroke
MRI
Research Site
 (3.1 away) Contact site
  • 217 views
  • 04 Sep, 2021
  • +222 other locations
A Long-term Study to Evaluate Safety and Maintenance of Treatment Effect of LY3074828 in Participants With Moderate-to-Severe Plaque Psoriasis (OASIS-3)

The purpose of this study is to evaluate the long-term safety and maintenance of efficacy of mirikizumab in participants with moderate-to-severe plaque psoriasis.

plaque psoriasis
mirikizumab
Clinical Partners LLC
 (5.2 away) Contact site
  • 717 views
  • 12 Sep, 2021
  • +361 other locations
Effect of Tumor Treating Fields (TTFields 200 kHz) Concomitant With Weekly Paclitaxel for the Treatment of Recurrent Ovarian Cancer (ENGOT-ov50 / GOG-3029 / INNOVATE-3)

The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of Tumor Treating Fields (TTFields) concomitant with weekly paclitaxel for the treatment of recurrent ovarian cancer . The device is an experimental, portable, battery operated device for chronic administration of alternating electric fields …

cancer of the ovary
paclitaxel
carcinoma
recurrent ovarian cancer
fallopian tube
Women & Infants Hospital of Rhode Island
 (2.4 away) Contact site
  • 276 views
  • 12 Sep, 2021
  • +140 other locations
Effect of Evolocumab in Patients at High Cardiovascular Risk Without Prior Myocardial Infarction or Stroke

This study will assess the effect of lowering low-density lipoprotein cholesterol (LDL-C) with evolocumab on major cardiovascular events in adults without a prior myocardial infarction (MI) or stroke who are at high risk of a cardiovascular event.

arterial disease
infarct
diabetes
stroke
myocardial infarction
Miriam Hospital
 (3.1 away) Contact site
  • 542 views
  • 15 Sep, 2021
  • +1332 other locations