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Philadelphia PennsyIvania, Pennsylvania Clinical Trials

A listing of Philadelphia PennsyIvania, Pennsylvania clinical trials actively recruiting patient volunteers.

RESULTS

Found (11) clinical trials

Ipilimumab and Nivolumab With Immunoembolization in Treating Participants With Metastatic Uveal Melanoma in the Liver

PRIMARY OBJECTIVES: I. Determine the clinical benefit of treatment with immunoembolization (IEMBO) in combination with ipilimumab and nivolumab. SECONDARY OBJECTIVES: I. Determine all treatment and immune related toxicities. II. Determine progression free survival. III. Determine overall survival.

Phase

0.41 miles

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Efficacy and Safety of Evinacumab in Patients With Homozygous Familial Hypercholesterolemia

The primary objective of the study is to demonstrate the reduction of low-density lipoprotein cholesterol (LDL-C) by evinacumab intravenously (IV) in comparison to placebo after 24 weeks in patients with homozygous familial hypercholesterolemia (HoFH). The secondary objectives of the study are to evaluate the effect of evinacumab IV on other ...

Phase

2.03 miles

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A Phase I/II Study of MEDI4736 in Combination With Olaparib in Patients With Advanced Solid Tumors.

This is a phase I/II open-label, multicenter study to evaluate the safety, tolerability, pharmacokinetics (PK) and antitumor activity of MEDI4736 in combination with olaparib in patients with advanced solid tumors, selected based on a rationale for response to olaparib. Patients will be poly (adenosine diphosphate-ribose) polymerase (PARP)-inhibitor and immunotherapy (IMT)-nave ...

Phase

2.03 miles

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Terameprocol in Treating Patients With Recurrent High Grade Glioma

PRIMARY OBJECTIVES: I. To estimate the maximum tolerated dose (MTD) of terameprocol given orally on days 1-5 every 28 days in patients with high grade glioma. (Part 1) II. To evaluate terameprocol tumor to plasma ratios in resected high grade gliomas following 5 days of oral terameprocol administration. (Part 2) ...

Phase

2.03 miles

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An Investigational Immuno-Therapy Study to Determine the Safety and Effectiveness of Nivolumab and Daratumumab in Patients With Multiple Myeloma

NOTE: Currently, this study is only open to nivolumab+daratumumab vs daratumumab monotherapy in multiple myeloma patients.

Phase

2.03 miles

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Effectiveness of Contrast-Enhanced Ultrasound

Abdominal trauma in children can be deadly, but intra-abdominal injuries can be difficult to detect and often lack external signs of injury on physical exam. The current gold standard imaging study is Computed Tomography (CT) with IV contrast, which is associated with radiation exposure. Contrast-enhanced ultrasound is a radiation-free alternative ...

Phase

2.03 miles

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CHaractErizing CFTR Modulated Changes in Sweat Chloride and Their Association With Clinical Outcomes

Eligible subjects who have been prescribed and chronically taking a commercially approved CFTR modulator for at least 3 months will be enrolled for a single visit to collect sweat to be analyzed for SC at their local site laboratory. Limited clinical data obtained at this visit will be augmented by ...

Phase N/A

2.03 miles

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Parent-Level Predictors of Early Language Interaction Quality and Training Outcomes

Early language intervention is critical to improving the academic, social, vocational, and health outcomes of at-risk children under five. This at-risk group includes approximately 1.7 million children with primary developmental language disorder (DLD), 350,000 children with autism spectrum disorder (ASD) and millions in adverse early environments (e.g., 5 million children ...

Phase N/A

2.03 miles

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Validating the MATADOC Against Best Practice Standard External Reference Standard

Adult patients with prolonged disorders of consciousness (PDOC), but who have not been diagnosed as Minimally Conscious or Vegetative State, will be recruited. All participants will be assessed using the Music Therapy Assessment Tool for Awareness in Disorders of Consciousness (MATADOC) standardized protocol. Assessment intervention will take place in four ...

Phase N/A

2.13 miles

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Molecular Monitoring With Circulating Tumor DNA and Nivolumab Maintenance

Primary Objective: To determine if nivolumab administration, as a maintenance strategy in DLBCL patients with high risk of relapse, can convert positive ctDNA to negative ctDNA and/or result in relapse free survival (RFS-ctDNA) of 9 months or longer after positive ctDNA was documented. Secondary Objectives: To evaluate safety of nivolumab ...

Phase N/A

8.61 miles

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