Monroeville, Pennsylvania Clinical Trials

A listing of Monroeville, Pennsylvania clinical trials actively recruiting patient volunteers.

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Found 19 clinical trials
Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia

The main purpose of this study is to evaluate the efficacy and safety of M281 in participants with warm autoimmune hemolytic anemia (wAIHA).

Momenta Investigational Site
 (9.9 away) Contact site
  • 15 views
  • 11 Jun, 2021
  • +131 other locations
A Study of the Safety and Effectiveness of DDP733 in Treating IBS With Constipation in Females

This study will evaluate the safety and effectiveness of the investigational drug DDP733 in treating female patients with IBS-c. A placebo control will be utilized.

abdominal pain
discomfort
constipation
Clinical Trials Research Services, LLC
 (8.4 away) Contact site
  • 5594 views
  • 07 Nov, 2020
  • +67 other locations
Antiandrogen Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With Prostate Cancer That Has Been Removed by Surgery

This randomized phase II/III trial studies docetaxel, antiandrogen therapy, and radiation therapy to see how well it works compared with antiandrogen therapy and radiation therapy alone in treating patients with prostate cancer that has been removed by surgery. Androgen can cause the growth of prostate cells. Antihormone therapy may lessen …

Jefferson Hospital
 (11.4 away) Contact site
  • 1468 views
  • 10 Jun, 2021
  • +328 other locations
Cisplatin and Combination Chemotherapy in Treating Children and Young Adults With Hepatoblastoma or Liver Cancer After Surgery

This partially randomized phase II/III trial studies how well, in combination with surgery, cisplatin and combination chemotherapy works in treating children and young adults with hepatoblastoma or hepatocellular carcinoma. Drugs used in chemotherapy, such as cisplatin, doxorubicin, fluorouracil, vincristine sulfate, carboplatin, etoposide, irinotecan, sorafenib, gemcitabine and oxaliplatin, work in different …

liver cancer
carboplatin
tumor cells
glomerular filtration rate
abdominal compartment syndrome
Children's Hospital of Pittsburgh of UPMC
 (9.9 away) Contact site
  • 178 views
  • 10 Jun, 2021
  • +136 other locations
Long-Term Follow-up Protocol for Subjects Treated With Gene-Modified T Cells

This is a prospective study for the long-term follow-up (LTFU) of safety and efficacy for all pediatric and adult subjects exposed to Gene-modified (GM) T cell therapy participating in a previous Celgene sponsored or Celgene alliance partner sponsored study. Subjects who received at least one GM T cell infusion, will …

treatment regimen
UPMC Cancer Pavillion
 (9.0 away) Contact site
  • 153 views
  • 21 Feb, 2021
  • +186 other locations
GRAVITAS-309: Itacitinib and Corticosteroids as Initial Treatment for Chronic Graft-Versus-Host Disease

The purpose of this study is to assess the efficacy and safety of itacitinib in combination with corticosteroids as first-line treatment for moderate or severe chronic graft-versus-host disease (cGVHD).

neutrophil count
cell transplantation
corticosteroids
platelet count
prednisone
University of Pittsburgh
 (9.1 away) Contact site
  • 0 views
  • 31 Mar, 2021
  • +143 other locations
De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage HPV-Positive Non-Smoking Associated Oropharyngeal Cancer

This phase II/III trial studies how well a reduced dose of radiation therapy works with nivolumab compared to cisplatin in treating patients with human papillomavirus (HPV)-positive oropharyngeal cancer that is early in its growth and may not have spread to other parts of the body (early-stage), and is not associated …

tumor cells
administration intravenous
neck cancer
neutrophil count
pet/ct scan
Wexford Health and Wellness Pavilion
 (20.2 away) Contact site
  • 16 views
  • 10 Jun, 2021
  • +224 other locations
Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

This screening and multi-sub-study randomized phase II/III trial will establish a method for genomic screening of similar large cancer populations followed by assigning and accruing simultaneously to a multi-sub-study hybrid Master Protocol (Lung-MAP). The type of cancer trait (biomarker) will determine to which sub-study, within this protocol, a participant will …

University of Pittsburgh Cancer Institute (UPCI)
 (9.0 away) Contact site
  • 193 views
  • 10 May, 2021
  • +876 other locations
A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma

Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM AGILE) is an international, seamless Phase II/III response adaptive randomization platform trial designed to evaluate multiple therapies in newly diagnosed (ND) and recurrent GBM.

recurrent glioblastoma
karnofsky performance status
gliosarcoma
recurrent disease
lomustine
University of Pittsburgh Medical Center - Hillman Cancer Center
 (9.0 away) Contact site
  • 105 views
  • 11 Jun, 2021
  • +35 other locations
Gemcitabine Plus Cisplatin With or Without Bintrafusp Alfa (M7824) in Participants With 1L Biliary Tract Cancer (BTC)

Study consists of an open-label, safety run-in part and a randomized, double-blind, placebo-controlled Phase 2/3 part. In the Phase 2/3 part, the study will evaluate whether bintrafusp alfa in combination with the current standard of care (SoC) (gemcitabine plus cisplatin) improves overall survival (OS) in chemotherapy and immunotherapy-nave participants with …

renal function
kidney function tests
antivirals
gemcitabine/cisplatin
gemcitabine
University of Kansas Medical Center Research Institute, Inc. - University of Kansas Cancer Center/Bloch Pavilion
 (9.0 away) Contact site
  • 173 views
  • 05 May, 2021
  • +125 other locations