Monroeville, Pennsylvania Clinical Trials

A listing of Monroeville, Pennsylvania clinical trials actively recruiting patient volunteers.

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Found 68 clinical trials
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A Phase 1b Study of INCMGA00012 in Combination With Other Therapies in Patients With Advanced Solid Tumors Carcinoma

The purpose of this study is to determine the safety, preliminary evidence of clinical activity, and recommended Phase 2 dose (RP2D) of INCMGA00012 in combination with other agents that may improve the therapeutic efficacy of anti-PD-1 monotherapy.

cancer
solid tumors
UPMC CANCER CENTER
 (9.0 away) Contact site
  • 25 views
  • 14 Dec, 2020
  • +8 other locations
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A safety and Tolerability Study of INCB053915 in Combination With INCB050465 in Diffuse Large B-Cell Lymphoma

The purpose of this study is to evaluate the safety and tolerability of INCB053914 in combination with INCB050465 in relapsed or refractory Diffuse Large B-Cell Lymphoma (DLBCL).  

lymphoma
lymphomas
b-cell lymphoma
WESTERN PENNSYLVANIA HOSPITAL
 (9.9 away) Contact site
  • 45 views
  • 14 Dec, 2020
  • +4 other locations
First In Human Study With ABBV-CLS-579 When Given Alone Or In Combination With Programmed Cell Death-1 Inhibitor In Participants With Locally Advanced Or Metastatic Tumors

The purpose of this study is to see how safe and effective ABBV-CLS-579 is when used alone or in combination with programmed cell death protein-1 (PD-1) inhibitors in treating solid cancers. ABBV-CLS-579 is an investigational drug being developed for the treatment of solid tumors. The study has two arms - …

UPMC Hillman Cancer Center
 (9.0 away) Contact site
  • 5 views
  • 18 Apr, 2021
  • +7 other locations
A Study of ASP1948 Targeting an Immune Modulatory Receptor as a Single Agent and in Combination With a PD-l Inhibitor (Nivolumab or Pembrolizumab) in Subjects With Advanced Solid Tumors

The purpose of this study is to evaluate the tolerability and safety profile of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab in participants with locally advanced (unresectable) or metastatic solid tumors; characterize the pharmacokinetic profile of ASP1948 when administered as a single agent …

UPMC- Hillman Cancer Center
 (9.0 away) Contact site
  • 75 views
  • 02 Jun, 2021
  • +55 other locations
A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma

The purpose of this study is to evaluate the effectiveness and safety of the combination of Pembrolizumab (KEYTRUDA) and the investigational drug, Metformin.

urine test
hba1c
neutrophil count
nivolumab
brain metastases
Univ of Pittsburgh Medical Center Hillman Cancer Center
 (9.0 away) Contact site
  • 0 views
  • 27 Jan, 2021
  • 1 location
A Study of TAK-676 and TAK-676 in Combination With Pembrolizumab in Adults With Advanced Solid Tumors

It is hoped that TAK-676, when given on its own or given with pembrolizumab will eventually help people with advanced or metastatic solid tumors. The main aim of this study is to check if people with advanced solid tumors have side effects from TAK-676, and to check how much TAK-676 …

University of Pittsburgh Medical Center - Hillman Cancer Center
 (9.1 away) Contact site
  • 0 views
  • 12 May, 2021
  • +8 other locations
A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid Tumors

This will be a Phase 1, open label, 2-sequence, crossover study to establish the BE of the current commercial formulation (Generation 3.1 talazoparib capsules) to the proposed talazoparib liquid-filled soft gelatin capsule (soft gel capsule) formulation after multiple dosing under fasting conditions in participants with advanced solid tumors. In addition, …

UPCI Investigational Drug Service
 (9.0 away) Contact site
  • 0 views
  • 12 Jun, 2021
  • +43 other locations
Study of Pembrolizumab With Pemetrexed and Oxaliplatin in Chemo-Refractory Metastatic Colorectal Cancer Patients

This is a Phase Ib study to evaluate the safety and preliminary anti-tumor activity of pembrolizumab in combination with pemetrexed with or without oxaliplatin in patients with chemo-refractory microsatellite stable (MSS) metastatic colorectal cancer (mCRC) without any further standard treatment options.

platelet count
oxaliplatin
heparin
international normalized ratio
ct scan
UPMC Hillman Cancer Center
 (9.0 away) Contact site
  • 4 views
  • 20 Apr, 2021
  • +15 other locations
Study of Fluphenazine in Relapsed or Relapsed-and-Refractory Multiple Myeloma

The purpose of this study is to evaluate the safety and tolerability of fluphenazine in patients with advanced multiple myeloma. The study will also describe the efficacy of this drug.

thalidomide
bortezomib
platelet count
proteasome inhibitor
lenalidomide
University of Pittsburgh Cancer Institute Hillman Cancer Center
 (9.0 away) Contact site
  • 11 views
  • 07 Nov, 2020
  • +2 other locations
A Study of the Safety of REN001 in Patients With Fatty Acid Oxidation Disorders

The purpose of this study is to assess REN001 safety in subjects with fatty acid oxidation disorders.

Children's Hospital of Pittsburgh
 (9.9 away) Contact site
  • 11 views
  • 27 Jan, 2021
  • +7 other locations