Monroeville, Pennsylvania Clinical Trials

A listing of Monroeville, Pennsylvania clinical trials actively recruiting patient volunteers.

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Found 513 clinical trials
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A Study Evaluating Tolerability and Efficacy of Navitoclax Alone or in Combination With Ruxolitinib in Participants With Myelofibrosis

www.MyelofibrosisResearch.com This is a Phase 2 open-label, multicenter study evaluating tolerability and efficacy of navitoclax alone or when added to ruxolitinib in participants with myelofibrosis.

UPMC Hillman Cancer Ctr /ID# 230731
 (9.1 away) Contact site
  • 251 views
  • 29 Apr, 2021
  • +134 other locations
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Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis

www.MyelofibrosisResearch.com Myelofibrosis is a type of bone marrow cancer that usually develops slowly and disrupts body's normal production of blood cells. It causes bone marrow scarring, leading to severe anemia that can cause weakness and fatigue. It can also cause a low number of blood-clotting cells called platelets, which increases …

UPMC Hillman Cancer Ctr /ID# 218134
 (9.1 away) Contact site
  • 32 views
  • 29 Apr, 2021
  • +148 other locations
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A Phase 1b Study of INCMGA00012 in Combination With Other Therapies in Patients With Advanced Solid Tumors Carcinoma

The purpose of this study is to determine the safety, preliminary evidence of clinical activity, and recommended Phase 2 dose (RP2D) of INCMGA00012 in combination with other agents that may improve the therapeutic efficacy of anti-PD-1 monotherapy.

cancer
solid tumors
UPMC CANCER CENTER
 (9.0 away) Contact site
  • 25 views
  • 14 Dec, 2020
  • +8 other locations
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GRAVITAS-301: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Itacitinib or Placebo in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease

GRAVITAS-301: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Itacitinib or Placebo in Combination With Corticosteroids for the Treatment of First-Line Acute Graft-Versus-Host Disease

graft-versus-host disease
UPMC Hillman Cancer Center
 (9.0 away) Contact site
  • 1462 views
  • 08 Dec, 2020
  • +10 other locations
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A Phase 2 Study of INCMGA00012 in Participants With Metastatic Merkel Cell Carcinoma

The purpose of this study is to assess the clinical activity and safety of INCMGA00012 in participants with metastatic merkel cell carcinoma (MCC).  

merkel cell carcinoma
measurable disease
cancer
metastatic cancer
metastatic merkel cell carcinoma
UPMC CANCERCENTER
 (9.6 away) Contact site
  • 101 views
  • 14 Dec, 2020
  • +6 other locations
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A safety and Tolerability Study of INCB053915 in Combination With INCB050465 in Diffuse Large B-Cell Lymphoma

The purpose of this study is to evaluate the safety and tolerability of INCB053914 in combination with INCB050465 in relapsed or refractory Diffuse Large B-Cell Lymphoma (DLBCL).  

b-cell lymphoma
lymphomas
lymphoma
WESTERN PENNSYLVANIA HOSPITAL
 (9.9 away) Contact site
  • 45 views
  • 14 Dec, 2020
  • +4 other locations
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Arise 2 - A Study of Oral BTD-001 in Adults With Idiopathic Hypersomnia

This is a randomized, placebo-controlled, double-blind, crossover study of oral BTD-001 in adults with Idiopathic Hypersomnia.  

hypersomnia
Consolidated Clinical Trials
 (8.1 away) Contact site
  • 607 views
  • 23 Nov, 2020
  • +17 other locations
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)

Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries. Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance. Participants will need to …

Novo Nordisk Investigational Site
 (9.9 away) Contact site
  • 0 views
  • 16 Jun, 2021
  • +242 other locations
Ravulizumab in Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplant

This study will evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of ravulizumab in adult and adolescent participants with hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA). In Stage 1, an open-label, single-arm period, the dosing regimen will be confirmed. In Stage 2, participants will be randomized to receive either blinded ravulizumab …

Clinical Trial Site
 (9.0 away) Contact site
  • 0 views
  • 04 May, 2021
  • +43 other locations
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

The purpose of the study is to determine if the combination of niraparib with Abiraterone Acetate (AA) plus prednisone compared with AA plus prednisone in participants with deleterious germline or somatic Homologous Recombination Repair (HRR) gene-mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC) provides superior efficacy in improving radiographic progression-free survival (rPFS).

University of Pittsburgh Medical Center (UPMC)
 (9.0 away) Contact site
  • 0 views
  • 02 Jun, 2021
  • +394 other locations