Salisbury, North Carolina Clinical Trials

A listing of Salisbury, North Carolina clinical trials actively recruiting patient volunteers.

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Found 17 clinical trials
A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer harboring selected fibroblast growth factor receptor (FGFR) aberrations who have progressed after 1 or 2 prior treatments, at least 1 of which includes an anti-programmed death ligand 1(PD-[L]1) agent …

carcinoma
adjuvant chemotherapy
growth factor
vinflunine
erdafitinib
Levine Cancer Institute, Carolinas HealthCare System
 (35.5 away) Contact site
  • 271 views
  • 01 Aug, 2021
  • +592 other locations
Study to Evaluate Adverse Events and Change in Disease Activity in Participants Between 18 to 75 Years of Age Treated With Subcutaneous (SC) Injections of ABBV-154 for Moderately to Severely Active Rheumatoid Arthritis (RA)

Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. This study evaluates how safe and effective ABBV-154 is in participants treated for moderately to severely active RA. Adverse events and change in the disease activity will be assessed. ABBV-154 is …

rheumatism
antirheumatics
methotrexate
stiffness
PMG Research of Salisbury /ID# 230627
 (3.6 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +292 other locations
Study to Assess the Efficacy Safety and Tolerability of AVP-786 for the Treatment of Neurobehavioral Disinhibition Including Aggression Agitation and Irritability in Patients With Traumatic Brain Injury

This is a multicenter, randomized, placebo-controlled study to evaluate AVP-786 for the treatment of neurobehavioral disinhibition including aggression, agitation, and irritability in participants with traumatic brain injury (TBI).

Atrium Health - Carolinas Rehabilitation - Charlotte
 (36.6 away) Contact site
  • 3060 views
  • 04 Aug, 2021
  • +83 other locations
Vitamin D3 With Chemotherapy and Bevacizumab in Treating Patients With Advanced or Metastatic Colorectal Cancer

This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Drugs used in chemotherapy, …

metastatic colorectal cancer
platelet count
metastasis
folfiri
neutrophil count
CaroMont Regional Medical Center
 (45.5 away) Contact site
  • 72 views
  • 27 Jul, 2021
  • +978 other locations
Effect of Tumor Treating Fields (TTFields) (150 kHz) Concurrent With Standard of Care Therapies for Treatment of Stage 4 Non-small Cell Lung Cancer (NSCLC) Following Platinum Failure (LUNAR)

The study is a prospective, randomized controlled phase III trial aimed to test the efficacy and safety of TTFields, using the NovoTTF-100L System, concurrent with standard therapies for stage 4 NSCLC patients, following progression while on or after platinum based treatment.The device is an experimental, portable, battery operated device for …

lung carcinoma
docetaxel
systemic therapy
Piedmont Radiation Oncology, PA
 (30.4 away) Contact site
  • 644 views
  • 30 Jul, 2021
  • +174 other locations
A Study of Baricitinib in Participants With Rheumatoid Arthritis

This post-marketing study is designed to compare the safety of baricitinib versus tumor necrosis factor (TNF) inhibitors with respect to venous thromboembolic events (VTEs) when given to participants with rheumatoid arthritis (RA).

baricitinib
tumour necrosis
tumor necrosis factor
body mass index
antirheumatics
PMG Research of Hickory, LLC
 (48.8 away) Contact site
  • 301 views
  • 24 Jul, 2021
  • +167 other locations
A Study of Neoadjuvant/Adjuvant Durvalumab for the Treatment of Patients With Resectable Non-small Cell Lung Cancer

This is a Phase III, randomized, double-blind, placebo-controlled, multi-center international study assessing the activity of durvalumab and chemotherapy administered prior to surgery compared with placebo and chemotherapy administered prior to surgery in terms of pathological complete response.

pemetrexed
carboplatin/paclitaxel
cancer chemotherapy
gemcitabine
durvalumab
Research Site
 (29.2 away) Contact site
  • 251 views
  • 31 Jul, 2021
  • +318 other locations
Study of Pembrolizumab (MK-3475) Plus Enzalutamide Versus Placebo Plus Enzalutamide in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-641/KEYNOTE-641)

The purpose of this study is to assess the efficacy and safety of the combination of pembrolizumab (MK-3475) and enzalutamide in the treatment of men with metastatic castration-resistant prostate cancer (mCRPC) who have not received chemotherapy for mCRPC, are abiraterone-nave, or are intolerant to or progressed on abiraterone acetate. There …

ct scan
metastasis
MRI
castration-resistant prostate cancer
androgen suppression
Blue Ridge Cancer Care ( Site 0086)
 (112.9 away) Contact site
  • 506 views
  • 04 Aug, 2021
  • +248 other locations
CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

This trial studies how well paclitaxel, trastuzumab, and pertuzumab work in eliminating further chemotherapy after surgery in patients with HER2-positive stage II-IIIa breast cancer who have no cancer remaining at surgery (either in the breast or underarm lymph nodes) after pre-operative chemotherapy and HER2-targeted therapy. Drugs used in chemotherapy, such …

ejection fraction
HER2
pertuzumab
neutrophil count
progesterone
Novant Health Cancer Institute - Rowan
 (3.6 away) Contact site
  • 43 views
  • 01 Aug, 2021
  • +576 other locations
Study to Describe the Safety Tolerability Immunogenicity and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Individuals

This is a Phase 1/2/3, randomized, placebo-controlled, observer-blind, dose-finding, vaccine candidate-selection, and efficacy study in healthy individuals. The study consists of 2 parts: Phase 1: to identify preferred vaccine candidate(s) and dose level(s); Phase 2/3: an expanded cohort and efficacy part. The study will evaluate the safety, tolerability, and immunogenicity …

SARS
covid-19
PMG Research of Salisbury, LLC
 (3.6 away) Contact site
  • 24084 views
  • 30 Jul, 2021
  • +198 other locations