Research Triangle Park, North Carolina Clinical Trials

A listing of Research Triangle Park, North Carolina clinical trials actively recruiting patient volunteers.

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Found 134 clinical trials
A Study to Evaluate the Efficacy and Safety of BIIB093 in Participants With Brain Contusion

The primary objective is to determine if BIIB093 reduces brain contusion expansion by Hour 96 when compared to placebo. The secondary objectives are to evaluate the effects of BIIB093 on acute neurologic status, functional outcomes, and treatment requirements, to further differentiate the mechanism of action of BIIB093 on contusion expansion …

coma
edema
head injury
Research site
 (9.8 away) Contact site
  • 378 views
  • 26 Sep, 2021
  • +67 other locations
Durvalumab Long-Term Safety and Efficacy Study

The aims of the study are to monitor the long-term safety of durvalumab, to provide continued treatment or retreatment with durvalumab to eligible patients, and to collect overall survival (OS) information.

antineoplastic
cancer treatment
Research Site
 (9.8 away) Contact site
  • 23 views
  • 27 Sep, 2021
  • +180 other locations
PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban

Currently, warfarin is the only approved anticoagulation for patients with mechanical valves. The purpose of this study is to determine if participants with an On-X Prosthetic Heart Valve / On-X aortic valve can be maintained safely and effectively on apixaban. Both the On-X aortic valve and apixaban have been approved …

apixaban 5 mg
warfarin
aspirin
Duke University
 (8.3 away) Contact site
  • 79 views
  • 22 Sep, 2021
  • +76 other locations
A Study to Assess the Safety and Efficacy of a Subcutaneous Formulation of Efgartigimod in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP an Autoimmune Disorder That Affects the Peripheral Nerves)

This is a Phase 2 study to evaluate the safety and efficacy of the subcutaneous formulation of efgartigimod in adults with CIDP.

prednisone
corticosteroids
ph20
cdas
polyneuropathy
Investigator site 108
 (8.3 away) Contact site
  • 366 views
  • 24 Sep, 2021
  • +124 other locations
Master Protocol to Assess the Safety and Antitumor Activity of Genetically Engineered T Cells in NY-ESO-1 and/or LAGE-1a Positive Solid Tumors

This trial will evaluate safety and efficacy of human engineered T-cell therapies, in participants with advanced tumors.

primary cancer
measurable disease
cyclophosphamide
solid neoplasm
sarcoma
GSK Investigational Site
 (8.3 away) Contact site
  • 4 views
  • 27 Sep, 2021
  • +34 other locations
A Study of Pembrolizumab (MK-3475) With or Without Lenvatinib (E7080/MK-7902) as First Line (1L) Intervention in a Programmed Cell Death-ligand 1 (PD-L1) Selected Population With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (R/M HNSCC) (LEAP-010) (MK-7902-010)

This is a study of pembrolizumab (MK-3475) with or without lenvatinib (E7080/MK-7902) as a first line intervention in a PD-L1 selected population with participants with recurrent or metastatic head and neck squamous cell carcinoma. Hypotheses include: Pembrolizumab + lenvatinib is superior to pembrolizumab + placebo with respect to Objective Response …

metastatic head and neck squamous cell carcinoma
pembrolizumab
cancer
measurable disease
primary tumor
Duke Cancer Center ( Site 0044)
 (8.3 away) Contact site
  • 15 views
  • 26 Sep, 2021
  • +150 other locations
A Study of Baricitinib in Participants With Rheumatoid Arthritis

This post-marketing study is designed to compare the safety of baricitinib versus tumor necrosis factor (TNF) inhibitors with respect to venous thromboembolic events (VTEs) when given to participants with rheumatoid arthritis (RA).

baricitinib
antirheumatics
DMARD
tumor necrosis factor
tumour necrosis
M3-Emerging Medical Research, LLC
 (9.6 away) Contact site
  • 301 views
  • 26 Sep, 2021
  • +171 other locations
Benralizumab Airway Remodeling Study in Severe Eosinophilic Asthmatics

The purpose of the study is to evaluate effect of benralizumab on structural and lung function changes in severe eosinophilic asthmatics. Changes will be assessed over 48 week treatment period in patients with persistent symptoms despite standard therapy of inhaled corticosteroids (ICS) plus long acting B2-agonist (LABA) with or without …

corticosteroids
airway remodelling
fluticasone
pulmonary function test
eosinophil count
Research Site
 (9.7 away) Contact site
  • 120 views
  • 15 Sep, 2021
  • +48 other locations
A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy

The purpose of this study is to assess the efficacy of seltorexant compared with quetiapine extended-release (XR) as adjunctive therapy to an antidepressant drug in treatment response in participants with major depressive disorder with insomnia symptoms (MDDIS) who have had an inadequate response to current antidepressant therapy with a selective …

psychosis
duloxetine
vortioxetine
vilazodone
scid
Velocity Clinical Research, Inc.
 (7.0 away) Contact site
  • 151 views
  • 27 Sep, 2021
  • +180 other locations
Pediatric Arthritis Study of Certolizumab Pegol

A Multicenter, Open-label Study to Assess the Pharmacokinetics, Safety and Efficacy of Certolizumab Pegol in Children and Adolescents With Moderately to Severely Active Polyarticular-course Juvenile Idiopathic Arthritis (JIA).

Ra0043 076
 (8.3 away) Contact site
  • 30 views
  • 16 Sep, 2021
  • +45 other locations