Research Triangle Park, North Carolina Clinical Trials

A listing of Research Triangle Park, North Carolina clinical trials actively recruiting patient volunteers.

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Found 124 clinical trials
A Research Study to Look at How Semaglutide Compared to Placebo Affects Diabetic Eye Disease in People With Type 2 Diabetes

This study will look at the long-term effects of semaglutide (active medicine) on diabetic eye disease when compared to placebo (dummy medicine). The study will be performed in people with type 2 diabetes. Participants will either get semaglutide or placebo in addition to their diabetes medicines - which treatment the …

hypoglycemic agents
Novo Nordisk Investigational Site
 (7.9 away) Contact site
  • 19 Sep, 2021
  • +237 other locations
Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

The researchers are doing the study to see if semaglutide may reduce the risk of having cardiovascular events in patients with overweight or obesity and with prior cardiovascular disease. The participant will either get semaglutide (active medicine) or placebo ("dummy" medicine). Which treatment the participants get is decided by chance. …

overweight or obesity
body mass index
cardiovascular disease
Novo Nordisk Investigational Site
 (7.9 away) Contact site
  • 19 Sep, 2021
  • +1166 other locations
A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform

Post-market prospective, multi-center longitudinal study to determine if mobile application-guided education and exercise paired with accurate and sensitive activity monitoring, captured from consumer wearables, can provide a viable (and potentially improved) alternative to current standard of care physical therapy for hip and knee arthroplasty.

hip arthroplasty
total knee replacement
partial knee replacement
Duke University
 (5.6 away) Contact site
  • 12 Sep, 2021
  • +33 other locations
Long-Term PF-06651600 for the Treatment of Alopecia Areata

This is a global Phase 3 study to evaluate the safety and effectiveness of an investigational study drug (called PF-06651600) in adults and adolescents (12 years and older) who have alopecia areata. Eligible patients from the prior studies B7931005 (NCT02974868) and B7981015 (NCT03732807) will have an opportunity to enroll as …

androgenic alopecia
alopecia totalis
alopecia universalis
 (9.8 away) Contact site
  • 19 Sep, 2021
  • +177 other locations
A Study of Mirikizumab (LY3074828) in Participants With Crohn's Disease

The reason for this study is to see if the study drug mirikizumab is safe and effective in participants with moderately to severely active Crohn's disease.

crohn's disease
UNC Children's Hospital
 (9.8 away) Contact site
  • 12 Sep, 2021
  • +1003 other locations
A Study of Tucatinib vs. Placebo in Combination With Ado-trastuzumab Emtansine (T-DM1) for Patients With Advanced or Metastatic HER2+ Breast Cancer

This study is being done to see if tucatinib with ado-trastuzumab emtansine (T-DM1) works better than T-DM1 alone to help patients who have a specific type of breast cancer called HER2 positive breast carcinoma. The breast cancer in this study is either metastatic (spread into other parts of the body) …

breast carcinoma
progesterone receptor
Duke University Medical Center
 (8.3 away) Contact site
  • 19 Sep, 2021
  • +236 other locations
A Study of Tirzepatide (LY3298176) Compared With Dulaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes

The purpose of the trial is to assess the efficacy and safety of tirzepatide to dulaglutide in participants with type 2 diabetes and increased cardiovascular risk.

cardiovascular disease
body mass index
hemoglobin a1c
Duke University Medical Center
 (8.3 away) Contact site
  • 12 Sep, 2021
  • +895 other locations
A Study to Evaluate the Efficacy and Safety of BIIB093 in Participants With Brain Contusion

The primary objective is to determine if BIIB093 reduces brain contusion expansion by Hour 96 when compared to placebo. The secondary objectives are to evaluate the effects of BIIB093 on acute neurologic status, functional outcomes, and treatment requirements, to further differentiate the mechanism of action of BIIB093 on contusion expansion …

head injury
Research site
 (9.8 away) Contact site
  • 19 Sep, 2021
  • +67 other locations
A Study of Baricitinib in Participants With Rheumatoid Arthritis

This post-marketing study is designed to compare the safety of baricitinib versus tumor necrosis factor (TNF) inhibitors with respect to venous thromboembolic events (VTEs) when given to participants with rheumatoid arthritis (RA).

tumour necrosis
body mass index
tumor necrosis factor
M3-Emerging Medical Research, LLC
 (9.6 away) Contact site
  • 12 Sep, 2021
  • +170 other locations
PROACT Xa - A Trial to Determine if Participants With an On-X Aortic Valve Can be Maintained Safely on Apixaban

Currently, warfarin is the only approved anticoagulation for patients with mechanical valves. The purpose of this study is to determine if participants with an On-X Prosthetic Heart Valve / On-X aortic valve can be maintained safely and effectively on apixaban. Both the On-X aortic valve and apixaban have been approved …

apixaban 5 mg
Duke University
 (8.3 away) Contact site
  • 19 Sep, 2021
  • +76 other locations