Research Triangle Park, North Carolina Clinical Trials

A listing of Research Triangle Park, North Carolina clinical trials actively recruiting patient volunteers.

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Found 129 clinical trials
2-level Cervical Disc Replacement Comparing Prodisc C SK & Vivo to Mobi-C

A multi-center, prospective, randomized, controlled comparison of the prodisc C SK and prodisc C Vivo to the control, a similar, legally marketed total disc replacement device in subjects with symptomatic cervical disc disease (SCDD).

M3-Emerging Medical Resarch
 (9.6 away) Contact site
  • 78 views
  • 17 Sep, 2021
  • +28 other locations
A Safety and Efficacy Study of FCR001 vs Standard of Care in de Novo Living Donor Kidney Transplantation

A randomized controlled study to assess the safety and efficacy and overall benefit of FCR001 cell therapy in de novo living donor renal transplantation.

Duke University Medical Center
 (8.3 away) Contact site
  • 23 views
  • 12 Sep, 2021
  • +15 other locations
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)

The purpose of this clinical research study is to learn more about the use of the study medicine, volixibat, for the treatment of pruritus (itching) associated with Primary Sclerosing Cholangitis (PSC), and to assess the possible impact on the disease progression of PSC.

Duke Health - Duke University Medical Center
 (9.4 away) Contact site
  • 0 views
  • 24 Sep, 2021
  • +27 other locations
A Study to Evaluate the Safety and Efficacy of Crizanlizumab in Sickle Cell Disease Related Priapism

The goal of the study is to evaluate the efficacy and safety of crizanlizumab in SCD patients with priapism.

Duke University Medical Center
 (8.3 away) Contact site
  • 23 views
  • 24 Sep, 2021
  • +16 other locations
A Study of Seltorexant Compared to Quetiapine XR as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy

The purpose of this study is to assess the efficacy of seltorexant compared with quetiapine extended-release (XR) as adjunctive therapy to an antidepressant drug in treatment response in participants with major depressive disorder with insomnia symptoms (MDDIS) who have had an inadequate response to current antidepressant therapy with a selective …

depressive symptoms
psychosis
fluvoxamine
vortioxetine
venlafaxine
Velocity Clinical Research, Inc.
 (7.0 away) Contact site
  • 148 views
  • 22 Sep, 2021
  • +180 other locations
Pediatric Arthritis Study of Certolizumab Pegol

A Multicenter, Open-label Study to Assess the Pharmacokinetics, Safety and Efficacy of Certolizumab Pegol in Children and Adolescents With Moderately to Severely Active Polyarticular-course Juvenile Idiopathic Arthritis (JIA).

Ra0043 076
 (8.3 away) Contact site
  • 30 views
  • 16 Sep, 2021
  • +45 other locations
A Study of Teclistamab in Participants With Relapsed or Refractory Multiple Myeloma

The purpose of this study is evaluate the efficacy of teclistamab at the recommended Phase 2 dose (RP2D).

measurable disease
multiple myeloma
Duke University Medical Center
 (8.3 away) Contact site
  • 0 views
  • 19 Sep, 2021
  • +71 other locations
Doravirine/Islatravir (DOR/ISL) in Pediatric Participants With Human Immunodeficiency Virus Type 1 (HIV-1) Who Are <18 Years of Age and Weigh 35 kg (MK-8591A-028)

This is a phase 2, single-group, multi-site, open-label study of an islatravir/doravirine (ISL/DOR, MK-8591A) fixed dose combination (FDC) for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in pediatric participants who are virologically suppressed (VS) on antiretroviral therapy (ART) for 3 months or are treatment-naive (TN). The primary …

Duke University ( Site 1807)
 (8.3 away) Contact site
  • 0 views
  • 23 Sep, 2021
  • +16 other locations
Study to Determine Recommended Phase 2 Dose of Intravenous (IV) Eftozanermin Alfa in Combination With IV or Subcutaneous (SC) Bortezomib and Oral Dexamethasone Tablet and to Assess Change in Disease Symptoms in Adult Participants With Relapsed or Refractory Multiple Myeloma

Multiple myeloma (MM) is a rare cancer caused by abnormal survival of plasma cells (blood cells). Most trial participants with MM relapse (cancer has come back) or become nonresponsive to treatment and remission gets shorter after each line of treatment. This is a study to determine recommended Phase 2 dose …

measurable disease
refractory multiple myeloma
dexamethasone
bortezomib
cancer
Duke University Hospital /ID# 222166
 (8.3 away) Contact site
  • 0 views
  • 22 Sep, 2021
  • +32 other locations
Study Of Oral Elagolix Tablets In Combination With Combined Oral Contraceptive Capsules/Tablets To Assess Dysmenorrhea Response In Adult Female Participants With Endometriosis And Associated Moderate To Severe Pain

Endometriosis is a painful disorder of the uterus affecting 6-10% of women of childbearing age. Endometriosis affects daily activities, social relationships, sexuality and sexual activity, and mental health. This study will evaluate how well elagolix in combination with combined oral contraceptives (COC) works within the body and/or how safe it …

combined oral contraceptives
elagolix
dysmenorrhea
endometriosis
Carolina Women's Research and Wellness Center /ID# 217133
 (3.1 away) Contact site
  • 494 views
  • 23 Sep, 2021
  • +204 other locations