Research Triangle Park, North Carolina Clinical Trials

A listing of Research Triangle Park, North Carolina clinical trials actively recruiting patient volunteers.

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Found 136 clinical trials
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C2541013 MIRNA NASH  

The study aims to evaluate two, orally administered, investigational agents - PF-06865571 (DGAT2 inhibitor) and the coadministration of PF-06865571 with PF-05221304 (ACC inhibitor). This study is specifically designed to evaluate the effect of a range of doses of DGAT2i alone, and DGAT2i + ACCi, on resolution of NASH or improvement …

M3 Wake Research Associates
 (9.8 away)
  • 275 views
  • 30 Jul, 2021
  • +64 other locations
featured
Phase 2 Trial of MRTX849 in Combination with Pembrolizumab in Patients with Advanced Non-Small Cell Lung Cancer with KRAS G12C Mutation (KRYSTAL-7)

This Phase 2 study evaluates the clinical activity and safety of MRTX849 in combination with pembrolizumab in cohorts of patients with advanced NSCLC with KRAS G12C mutation and any PD-L1 TPS.

pembrolizumab
KRAS
Duke University Medical Center
 (8.5 away) Contact site
  • 0 views
  • 28 Jul, 2021
  • +40 other locations
A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy Compared With Carboplatin-Pemetrexed in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions

The purpose of this study is to compare the efficacy, as demonstrated by progression-free survival (PFS), in participants treated with amivantamab in combination with chemotherapy, versus chemotherapy alone in participants with locally advanced or metastatic non-small cell lung cancer (NSCLC) characterized by EGFR Exon 20ins mutations.

EGFR
cancer chemotherapy
epidermal growth factor
pemetrexed
epidermal growth factor receptor
Durham VAMC
 (9.7 away) Contact site
  • 0 views
  • 29 Jul, 2021
  • +281 other locations
A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for the Treatment of Participants With Deleterious Germline or Somatic Homologous Recombination Repair (HRR) Gene-Mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC)

The purpose of the study is to determine if the combination of niraparib with Abiraterone Acetate (AA) plus prednisone compared with AA plus prednisone in participants with deleterious germline or somatic Homologous Recombination Repair (HRR) gene-mutated Metastatic Castration-Sensitive Prostate Cancer (mCSPC) provides superior efficacy in improving radiographic progression-free survival (rPFS).

Durham VAMC
 (9.7 away) Contact site
  • 0 views
  • 02 Aug, 2021
  • +397 other locations
ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19

This study looks at the safety and effectiveness of different drugs in treating COVID-19 in people who have been hospitalized with the infection and who have acute respiratory failure. Participants in the study will be treated with either a study drug plus current standard of care (SOC), or with placebo …

Duke University Hospital (Site 301-006), 2301 Erwin Road
 (8.3 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +38 other locations
COVID-19 Thrombosis Prevention Trials: Post-hospital Thromboprophylaxis

A multicenter, adaptive, randomized platform trial evaluating the efficacy and safety of antithrombotic strategies in patients with COVID-19 following hospital discharge

Duke Medical Center
 (9.7 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +74 other locations
Research Study on Whether Semaglutide Works in People With Non-alcoholic Steatohepatitis (NASH)

Semaglutide is a medicine studied in patients with NASH. Semaglutide is a well-known medicine, which is already used by doctors to treat type 2 diabetes in many countries. Participants will either get semaglutide or a dummy medicine - which treatment participants get is decided by chance. Participants will need to …

Novo Nordisk Investigational Site
 (9.7 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +256 other locations
A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations

The purpose of this study is to evaluate efficacy of erdafitinib versus chemotherapy or pembrolizumab in participants with advanced urothelial cancer harboring selected fibroblast growth factor receptor (FGFR) aberrations who have progressed after 1 or 2 prior treatments, at least 1 of which includes an anti-programmed death ligand 1(PD-[L]1) agent …

pembrolizumab
transitional cell carcinoma
docetaxel
advanced urothelial carcinoma
carcinoma
Duke University
 (7.0 away) Contact site
  • 271 views
  • 01 Aug, 2021
  • +592 other locations
Long Term Extension Study of the Safety and Efficacy of AVP-786 for the Treatment of Agitation in Patients With Dementia of the Alzheimer's Type

This is an extension study of the Phase 3 Studies 15-AVP-786-301, 15-AVP-786-302, and 17-AVP-786-305, which also allows participants from the Phase 2 Study 12-AVR-131 to be included.

Herbert Harris, Md, Phd, Pa
 (7.9 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +296 other locations
A Study of Rucaparib Versus Physician's Choice of Therapy in Patients With Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency

The purpose of this study is to determine how patients with metastatic castration-resistant prostate cancer, and evidence of a homologous recombination gene deficiency, respond to treatment with rucaparib versus treatment with physician's choice of abiraterone acetate, enzalutamide, or docetaxel.

Durham VA Medical Center
 (9.7 away) Contact site
  • 2496 views
  • 24 Jul, 2021
  • +209 other locations