Raleigh, North Carolina Clinical Trials

A listing of Raleigh, North Carolina clinical trials actively recruiting patient volunteers.

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Found 71 clinical trials
Study of Pembrolizumab (MK-3475) Plus Chemotherapy Versus Placebo Plus Chemotherapy for HR+/HER2- Locally Recurrent Inoperable or Metastatic Breast Cancer (MK-3475-B49/KEYNOTE-B49)

The safety and efficacy of pembrolizumab plus the investigator's choice of chemotherapy will be assessed compared to placebo plus the investigator's choice of chemotherapy in the treatment of chemotherapy-candidate hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) locally recurrent inoperable or metastatic breast cancer. The primary hypotheses are that …

progesterone receptor
estrogen
endocrine therapy
core needle biopsy
bisphosphonate
Waverly Hematology Oncology ( Site 0015)
 (8.5 away) Contact site
  • 0 views
  • 19 Sep, 2021
  • +29 other locations
A Randomized Double-Blind Parallel Group Placebo-Controlled Study to Assess STS101 in the Acute Treatment of Migraine

Study STS101-007 is a randomized, double-blind, parallel group, placebo-controlled, multicenter study to evaluate the efficacy, safety, and tolerability of single doses of STS101 (dihydroergotamine nasal powder) in the acute treatment of migraine.

headache
dihydroergotamine
acute treatment
North Carolina Clinical Research
 (3.7 away) Contact site
  • 5 views
  • 12 Sep, 2021
  • +142 other locations
Study to Evaluate the Safety and Efficacy of a Booster Dose of BNT162b2 Against COVID-19 in Participants 16 Years of Age.

The study will evaluate the safety, tolerability, and efficacy of a booster dose of BNT162b2 when administered to participants having previously received 2 doses of BNT162b2 at least 6 months prior to randomization. The study is designed to describe vaccine efficacy of a booster dose of BNT162b2 over time against …

Accellacare
 (4.7 away) Contact site
  • 29 views
  • 19 Sep, 2021
  • +139 other locations
A Study to Test if Fremanezumab is Effective in Preventing Chronic Migraine in Patients 6 to 17 Years of Age

The primary objective of the study is to evaluate the effectiveness of fremanezumab as compared to placebo for the preventive treatment of chronic migraine (CM). Secondary objectives are to further demonstrate the efficacy of Fremanezumab as compared to placebo for the preventive treatment of CM, to evaluate the safety and …

fremanezumab
daily headaches
recurrent headaches
headache
chronic migraine
Teva Investigational Site 14248
 (3.7 away) Contact site
  • 0 views
  • 19 Sep, 2021
  • +69 other locations
Safety and Tolerability Study Of PF-06835375 In Subjects With Seropositive Systemic Lupus Erythematosus Or Rheumatoid Arthritis

This is a Phase 1 single and multiple dose escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06835375 in subjects with seropositive SLE or RA. The design is double-blind, sponsor open and placebo controlled. This study will include two parts: Part A and Part B. Part A …

antinuclear antibody
lupus
rheumatoid factor
arthritis
Carolina Phase 1 Research, LLC
 (6.2 away) Contact site
  • 1053 views
  • 09 Sep, 2021
  • +23 other locations
A Study of an Intratumoral Oncolytic Virus in Patients With Advanced Metastatic Solid Tumors

The purpose of this study is to assess the safety and tolerability of ASP9801 and to determine the recommended phase 2 dose (RP2D). The study will also evaluate antitumor activity, objective response rate, pharmacokinetics and virus shedding of ASP9801.

solid neoplasm
measurable disease
solid tumor
Greenville Health System Cancer Institute
 (1.7 away) Contact site
  • 18 views
  • 19 Sep, 2021
  • +19 other locations
A Study to Test the Effectiveness and Safety of Fremanezumab on Patients With Fibromyalgia

The primary objective of the study is to estimate the treatment effect of fremanezumab administered subcutaneously in reducing pain in adult patients with FM. A secondary objective is to evaluate the effect of fremanezumab on other efficacy measures, including pain, quality of life, sleep, fatigue, improvement in health, physical functioning, …

fatigue
body mass index
hysterectomy
sham treatment
Teva Investigational Site 14152
 (4.7 away) Contact site
  • 4508 views
  • 19 Sep, 2021
  • +44 other locations
TORUS 2 IDE Clinical Study

The primary objective of the TORUS 2 IDE Clinical Study is to evaluate the safety and effectiveness of the TORUS Stent Graft System in the treatment of obstructive atherosclerotic lesions of the native SFA or the superficial femoral and/or proximal popliteal arteries.

stenosis
arteriopathy
stenotic
vascular disease
angiography
NC Heart & Vascular Research
 (3.7 away) Contact site
  • 17 views
  • 19 Sep, 2021
  • +33 other locations
Venous Stent for the Iliofemoral Vein Investigational Clinical Trial Using the DUO Venous Stent System

This is a prospective, multi-center, single-arm, non-blinded clinical trial designed to investigate the safety and efficacy of the Vesper DUO Venous Stent System as compared to a pre-defined performance goal (PG) established from published, peer reviewed scientific literature related to stenting of iliofemoral venous outflow obstructions.

blood clot
embolism
body mass index
deep vein thrombosis
dvts
NC Heart and Vascular
 (3.7 away) Contact site
  • 0 views
  • 19 Sep, 2021
  • +30 other locations
A Study of the Safety and Efficacy of SP-624 in the Treatment of Adults With Major Depressive Disorder

This is a Phase 2 clinical study evaluating the safety and effectiveness of SP-624 as compared to placebo in the treatment of adults with Major Depressive Disorder.

major depressive disorder
body mass index
Richard H. Weisler, MD, PA & Associates
 (4.7 away) Contact site
  • 12 views
  • 08 Sep, 2021
  • +32 other locations