Raleigh, North Carolina Clinical Trials

A listing of Raleigh, North Carolina clinical trials actively recruiting patient volunteers.

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Found 71 clinical trials
A Study of Pembrolizumab (MK-3475) With or Without Maintenance Olaparib in First-line Metastatic Squamous Non-small Cell Lung Cancer (NSCLC MK-7339-008/KEYLYNK-008)

The current study will compare pembrolizumab (MK-3475) plus maintenance olaparib, vs. pembrolizumab plus maintenance olaparib placebo for the treatment of squamous NSCLC. The study's 2 primary hypotheses are: Pembrolizumab plus maintenance olaparib is superior to pembrolizumab plus maintenance olaparib placebo with respect to progression-free survival (PFS) per RECIST 1.1 by …

Waverly Hematology Oncology ( Site 0054)
 (8.5 away) Contact site
  • 119 views
  • 22 Sep, 2021
  • +202 other locations
This Study Tests Whether BI 425809 Together With Brain Training Using a Computer Improves Mental Functioning in Patients With Schizophrenia

This is a study in adults with schizophrenia. The study tests whether a medicine called BI 425809 together with brain training improves mental abilities. Participants take study medication once a day for 12 weeks. At the start of the study, the participants are put into 2 groups. It is decided …

clozapine
antidepressants
anticholinergics
antipsychotics
cognitive training
North Carolina Psychiatric Research Center
 (4.7 away) Contact site
  • 773 views
  • 18 Sep, 2021
  • +59 other locations
Long Term Extension Trial of Setmelanotide

This is a long-term extension trial to study the safety and tolerability of continued setmelanotide treatment in patients who have completed a previous clinical trial on treatment with setmelanotide for obesity associated with genetic defects upstream of the MC4 receptor in the leptin-melanocortin pathway.

Wake Research
 (6.2 away) Contact site
  • 38 views
  • 22 Sep, 2021
  • +36 other locations
Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity

The researchers are doing the study to see if semaglutide may reduce the risk of having cardiovascular events in patients with overweight or obesity and with prior cardiovascular disease. The participant will either get semaglutide (active medicine) or placebo ("dummy" medicine). Which treatment the participants get is decided by chance. …

body mass index
cardiovascular disease
overweight or obesity
Novo Nordisk Investigational Site
 (6.6 away) Contact site
  • 7778 views
  • 22 Sep, 2021
  • +1166 other locations
A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men

This is a blinded and placebo-controlled study of topical testosterone replacement therapy (TRT) in symptomatic hypogonadal men with increased risk for cardiovascular (CV) disease.

testosterone topical
testosterone
testosterone level
replacement therapy
serum testosterone
Family Medical Associates of Raleigh /ID# 203979
 (4.7 away) Contact site
  • 16902 views
  • 09 Sep, 2021
  • +495 other locations
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG

The primary objective of this study is to evaluate the effectiveness (prevention of thromboembolic events) and safety (major bleeding) of adding oral anticoagulation (OAC) to background antiplatelet therapy in patients who develop new-onset post-operative atrial fibrillation (POAF) after isolated coronary artery bypass graft (CABG) surgery. All patients with a qualifying …

antiplatelet therapy
edoxaban
dabigatran
apixaban
fibrillation
WakeMed
 (1.8 away) Contact site
  • 112 views
  • 23 Sep, 2021
  • +79 other locations
A Trial to Evaluate the Efficacy and Safety of RSVpreF in Infants Born to Women Vaccinated During Pregnancy.

This randomized, double-blinded, placebo-controlled Phase 3 study is designed to evaluate the efficacy and safety of maternal immunization with RSVpreF against medically attended lower respiratory tract illness (MA-LRTI) in infants.

vaccination
lower respiratory tract infection
prenatal
WakeMed Health & Hospitals
 (1.8 away) Contact site
  • 138 views
  • 21 Sep, 2021
  • +463 other locations
Long-term Safety and Efficacy Study of Lebrikizumab (LY3650150) in Participants With Moderate-to-Severe Atopic Dermatitis (ADjoin)

This 110-week study is designed to assess the long-term safety and efficacy of lebrikizumab for moderate-to-severe atopic dermatitis.

lebrikizumab
progestogen
hormonal contraception
topical agents
eczema
Wake Research Associates
 (6.6 away) Contact site
  • 154 views
  • 22 Sep, 2021
  • +357 other locations
A Study to Test if Fremanezumab is Effective in Preventing Episodic Migraine in Patients 6 to 17 Years of Age

The primary objective of the study is to evaluate the effectiveness of fremanezumab as compared to placebo for the preventive treatment of episodic migraine (EM). Secondary objectives are to further demonstrate the efficacy of Fremanezumab as compared to placebo for the preventive treatment of EM, to evaluate the safety and …

fremanezumab
headache
recurrent headaches
daily headaches
episodic migraine
Teva Investigational Site 14248
 (3.7 away) Contact site
  • 51 views
  • 22 Sep, 2021
  • +69 other locations
Study to Assess PT010 in Adult and Adolescent Participants With Inadequately Controlled Asthma (KALOS)

This is a variable length study to evaluate the efficacy and safety of budesonide/glycopyrronium/formoterol inhaler in adults and adolescents with severe asthma inadequately controlled with standard of care.

Research Site
 (1.8 away) Contact site
  • 5 views
  • 23 Sep, 2021
  • +351 other locations