Search Medical Condition
Please enter condition
Please choose location from dropdown
Clear Trial Filters

Raleigh-Durham, North Carolina Clinical Trials

A listing of Raleigh-Durham, North Carolina clinical trials actively recruiting patient volunteers.

RESULTS

Found (12) clinical trials

The purpose of this study will be to evaluate the safety, tolerability, and pharmacological activity of INCB054828 in subjects with advanced malignancies. This study will have three parts, dose escalation (Part 1), dose expansion (Part 2) and combination therapy (Part 3).

Phase N/A

6.84 miles

Learn More »

NC Young Women's CoOperative (CoOp)

The purpose of this study is to use the seek, test, treat, and retain framework to develop and test the efficacy of a clinic-based, age-appropriate, woman-focused HIV intervention to reduce sexual risk and increase the receipt of health services among 700 young sexually active and drug-using, African American women aged ...

Phase N/A

6.99 miles

Learn More »

The Menopause Transition: Estrogen Variability Stress Reactivity and Mood

Framed within a diathesis-stress model, the primary objective of this research is to determine the pathophysiological mechanisms of estradiol (E2) in the clinical anxiety and anhedonia seen in the menopause transition (MT). Specifically whether E2 variability or E2 levels predict exaggerated hypothalamic-pituitary-adrenal (HPA) axis reactivity and impaired recovery to stress ...

Phase

7.94 miles

Learn More »

A Phase 3 clinical study for patients with Prematurity, Patent Ductus Arteriosus After Premature Birth, Neonatal disorder, Patent ductus arteriosus

This is a pragmatic randomized multicenter, effectiveness study comparing active treatment of a symptomatic patent ductus arteriosus (sPDA) to expectant management. We hypothesize in premature infants with a sPDA, expectant management reduces the incidence proportion of death or BPD by 10% (from 50% to 40%) when compared to active treatment. ...

Phase

8.36 miles

Learn More »

A Randomized Trial to Assess Patient Quality of Life and Function After Alternative Surgeries for Pathologic Fractures of the Femur

The purpose of this study is to look at two different types of surgeries regularly used for treating cancer that has spread to and weakened the thigh bone (femur). Because it is not known which of these surgeries is best, the investigators will compare the results of the two procedures. ...

Phase N/A

9.57 miles

Learn More »

An Open-Label Phase 3 Study to Examine the Long-Term Safety Tolerability and Efficacy of APL-130277 for the Acute Treatment of "OFF" Episodes in Patients With Parkinson's Disease

A 24-week, prospective, multi-center, open-label, Phase 3 study in L-Dopa responsive PD patients with motor fluctuations ("OFF" episodes), designed to evaluate the long-term safety, tolerability and efficacy of APL-130277.

Phase

9.69 miles

Learn More »

Follow-up Visit of High Risk Infants

The NICHD Neonatal Research Network's Follow-Up study is a multi-center cohort study in which surviving extremely low birth-weight infants undergo neurodevelopmental, neurosensory and functional assessments at 22-26 months corrected age (Infants born prior to July 1, 2012 were seen at 18-22 month corrected age). The goal of the study is ...

Phase N/A

9.69 miles

Learn More »

Preemie Hypothermia for Neonatal Encephalopathy

Most clinical studies of neonatal encephalopathy (NE) and potential interventions have focused on infants 36 weeks GA. Although many interventions have been suggested and assessed for prevention or palliation of NE, the only one currently supported by rigorous clinical evidence to improve outcome in human newborns has been hypothermia implemented ...

Phase

9.69 miles

Learn More »

Donor Milk vs. Formula in Extremely Low Birth Weight (ELBW) Infants

There is strong evidence that maternal breast milk feedings in infancy confer multiple health benefits in the extremely preterm population (extremely low birth weight, ELBW, <1000 g). Studies suggest an IQ advantage of up to 8 points conferred by maternal milk feeding in this population. Rates of sepsis and necrotizing ...

Phase

9.69 miles

Learn More »