North Wilkesboro, North Carolina Clinical Trials

A listing of North Wilkesboro, North Carolina clinical trials actively recruiting patient volunteers.

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Found 11 clinical trials
CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

This trial studies how well paclitaxel, trastuzumab, and pertuzumab work in eliminating further chemotherapy after surgery in patients with HER2-positive stage II-IIIa breast cancer who have no cancer remaining at surgery (either in the breast or underarm lymph nodes) after pre-operative chemotherapy and HER2-targeted therapy. Drugs used in chemotherapy, such …

tumor cells
chemotherapy drugs
ejection fraction
lumpectomy
hepatitis c virus
Novant Health Oncology Specialists-Wilkesboro
 (5.2 away) Contact site
  • 43 views
  • 01 Aug, 2021
  • +576 other locations
Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer

This phase II/III trials studies whether maintenance immunotherapy (nivolumab) following definitive treatment with radiation and chemotherapy (cisplatin) result in significant improvement in overall survival (time being alive) and progression-free survival (time being alive without cancer) for patients with intermediate risk human papillomavirus (HPV) positive oropharynx cancer (throat cancer) that has …

Novant Health Oncology Specialists-Wilkesboro
 (5.2 away) Contact site
  • 135 views
  • 04 Aug, 2021
  • +539 other locations
Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma

This phase III trial compares immunotherapy drugs (nivolumab or brentuximab vedotin) when given with combination chemotherapy in treating patients with newly diagnosed stage III or IV classic Hodgkin lymphoma. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's immune system attack the cancer, and may interfere with the …

tumor cells
hypothyroidism
hysterectomy
estimated creatinine clearance
prednisone
Novant Health Oncology Specialists-Wilkesboro
 (9.0 away) Contact site
  • 68 views
  • 04 Aug, 2021
  • +507 other locations
Chemoradiation With or Without Atezolizumab in Treating Patients With Limited Stage Small Cell Lung Cancer

This phase III trial studies how well chemotherapy and radiation therapy (chemoradiation) with or without atezolizumab works in treating patients with limited stage small cell lung cancer. Drugs used in chemotherapy, such as etoposide, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by …

Novant Health Oncology Specialists-Wilkesboro
 (5.2 away) Contact site
  • 85 views
  • 04 Aug, 2021
  • +334 other locations
Immunotherapy With Nivolumab and Ipilimumab Followed by Nivolumab or Nivolumab With Cabozantinib for Patients With Advanced Kidney Cancer The PDIGREE Study

This phase III trial compares the usual treatment (treatment with ipilimumab and nivolumab followed by nivolumab alone) to treatment with ipilimumab and nivolumab, followed by nivolumab with cabozantinib in patients with untreated renal cell carcinoma that has spread to other parts of the body. The addition of cabozantinib to the …

carcinoma
tumor cells
metastasis
kidney cancer
platelet count
Novant Health Oncology Specialists-Wilkesboro
 (5.2 away) Contact site
  • 157 views
  • 04 Aug, 2021
  • +680 other locations
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors Lymphomas or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

gnrh
solid tumour
heart failure
systemic therapy
alopecia
Novant Health Oncology Specialists-Wilkesboro
 (5.2 away) Contact site
  • 6088 views
  • 04 Aug, 2021
  • +1020 other locations
Testing The Addition of a New Anti-cancer Drug Venetoclax to the Usual Treatment (Ibrutinib and Obinutuzumab) in Untreated Older Patients With Chronic Lymphocytic Leukemia

This phase III trial compares adding a new anti-cancer drug (venetoclax) to the usual treatment (ibrutinib plus obinutuzumab) in older patients with chronic lymphocytic leukemia who have not received previous treatment. The addition of venetoclax to the usual treatment might prevent chronic lymphocytic leukemia from returning. This trial also will …

thrombocytopenia
platelet count
immunoglobulin
neutrophil count
anemia
Novant Health Oncology Specialists-Wilkesboro
 (5.2 away) Contact site
  • 374 views
  • 04 Aug, 2021
  • +738 other locations
Nivolumab and Ipilimumab in Treating Patients With Esophageal and Gastroesophageal Junction Adenocarcinoma Undergoing Surgery

This phase II/III trial studies the usefulness of treatment with nivolumab and ipilimumab in addition to standard of care chemotherapy and radiation therapy in patients with esophageal and gastroesophageal junction adenocarcinoma who are undergoing surgery. Immunotherapy with antibodies, such as nivolumab and ipilimumab, may remove the brake on the body's …

tumor cells
carboplatin
hysterectomy
esophagectomy
diabetes
Novant Health Cancer Institute - Wilkesboro
 (9.0 away) Contact site
  • 11 views
  • 04 Aug, 2021
  • +286 other locations
BLAST MRD AML-1: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 1- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Intensive Chemotherapy as Frontline Therapy in Patients With Acute Myeloid Leukemia

This phase II trial studies how well cytarabine and idarubicin or daunorubicin with or without pembrolizumab work in treating patients with newly-diagnosed acute myeloid leukemia. Drugs used in chemotherapy, such as cytarabine, idarubicin, and daunorubicin, work in different ways to stop the growth of cancer cells, either by killing the …

blast cells
induction chemotherapy
tyrosine
hydroxyurea
leukapheresis
Wake Forest Baptist Health - Wilkes Medical Center
 (9.0 away) Contact site
  • 0 views
  • 23 Jul, 2021
  • +8 other locations
Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

This phase III trial compares the effect of bevacizumab and osimertinib combination vs. osimertinib alone for the treatment of non-small cell lung cancer that has spread outside of the lungs (stage IIIB-IV) and has a change (mutation) in a gene called EGFR. The EGFR protein is involved in cell signaling …

Novant Health Cancer Institute - Wilkesboro
 (9.0 away) Contact site
  • 0 views
  • 04 Aug, 2021
  • +365 other locations