Greenville, North Carolina Clinical Trials

A listing of Greenville, North Carolina clinical trials actively recruiting patient volunteers.

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Found 28 clinical trials
Ivosidenib in Treating Patients With Advanced Solid Tumors Lymphoma or Histiocytic Disorders With IDH1 Mutations (A Pediatric MATCH Treatment Trial)

This phase II Pediatric MATCH trial studies how well ivosidenib works in treating patients with solid tumors that have spread to other places in the body (advanced), lymphoma, or histiocytic disorders that have IDH1 genetic alterations (mutations). Ivosidenib may block the growth of cancer cells that have specific genetic changes …

cns metastases
nervous system disorder
myelosuppressive chemotherapy
nitrosourea
blood count
East Carolina University
 (2.7 away) Contact site
  • 37 views
  • 01 Aug, 2021
  • +88 other locations
Tipifarnib for the Treatment of Advanced Solid Tumors Lymphoma or Histiocytic Disorders With HRAS Gene Alterations a Pediatric MATCH Treatment Trial

This phase II pediatric MATCH trial studies how well tipifarnib works in treating patients with solid tumors that have recurred or spread to other places in the body (advanced), lymphoma, or histiocytic disorders, that have a genetic alteration in the gene HRAS. Tipifarnib may block the growth of cancer cells …

cns metastases
nervous system disorder
myelosuppressive chemotherapy
nitrosourea
blood count
East Carolina University
 (2.7 away) Contact site
  • 10 views
  • 01 Aug, 2021
  • +86 other locations
Selpercatinib for the Treatment of Advanced Solid Tumors Lymphomas or Histiocytic Disorders With Activating RET Gene Alterations a Pediatric MATCH Treatment Trial

This phase II pediatric MATCH trial studies how well selpercatinib works in treating patients with solid tumors that have spread to other places in the body (advanced), lymphomas, or histiocytic disorders that have activating RET gene alterations. Selpercatinib may block the growth of cancer cells that have specific genetic changes …

cns metastases
myelosuppressive chemotherapy
nitrosourea
blood count
glomerular filtration rate
East Carolina University
 (2.7 away) Contact site
  • 17 views
  • 02 Aug, 2021
  • +87 other locations
Symphony-2 A Trial to Examine Combination of Tazemetostat and Rituximab for Patients With Relapsed/Refractory Follicular Lymphoma

The goal of this study is to examine the feasibility and efficacy of adding the EZH2 inhibitor, tazemetostat, to rituximab, standard second line or beyond therapy as a means to improve disease response.

follicular lymphoma
rituximab
refractory follicular lymphoma
East Carolina University
 (2.5 away) Contact site
  • 0 views
  • 07 Jul, 2021
  • +7 other locations
ACTIV-5 / Big Effect Trial (BET-A) for the Treatment of COVID-19

This is a platform trial to conduct a series of randomized, double-blind, placebo-controlled trials using common assessments and endpoints in hospitalized adults diagnosed with Coronavirus Disease 2019 (COVID-19). Big Effect Trial (BET) is a proof-of-concept study with the intent of identifying promising treatments to enter a more definitive study. The …

East Carolina University Brody School of Medicine - Adult Specialty Care
 (2.7 away) Contact site
  • 35 views
  • 01 Aug, 2021
  • +54 other locations
ACTIV-5 / Big Effect Trial (BET-B) for the Treatment of COVID-19

This is a platform trial to conduct a series of randomized, double-blind, placebo-controlled trials using common assessments and endpoints in hospitalized adults diagnosed with Coronavirus Disease 2019 (COVID-19). Big Effect Trial (BET) is a proof-of-concept study with the intent of identifying promising treatments to enter a more definitive study. The …

East Carolina University Brody School of Medicine - Adult Specialty Care
 (2.7 away) Contact site
  • 28 views
  • 01 Aug, 2021
  • +63 other locations
DOTS: Dalbavancin as an Option for Treatment of Staphylococcus Aureus Bacteremia

This is a Phase 2b clinical study, multicenter, randomized, open-label, assessor-blinded, superiority study. The study will compare dalbavancin to standard of care antibiotic therapy for the completion of therapy in patients with complicated bacteremia or right-sided native valve Infective Endocarditis (IE) caused by S. aureus who have cleared their baseline …

East Carolina University - Infectious Diseases and Tropical/Travel Medicine Clinic
 (2.7 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +21 other locations
A Study to Evaluate the Efficacy and Safety of Vonoprazan Compared to Placebo in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux Disease

The primary objectives of this study are to assess the efficacy of vonoprazan (10 mg, 20 mg, and 40 mg On-Demand) compared to placebo (On-Demand) in relief of episodic heartburn over 6 weeks in participants with symptomatic non-erosive gastroesophageal reflux disease (NERD), and to assess the safety of vonoprazan (10 …

gastroesophageal reflux
reflux
Carolina Digestive Diseases
 (2.7 away) Contact site
  • 0 views
  • 01 Aug, 2021
  • +53 other locations