Greenville, North Carolina Clinical Trials

A listing of Greenville, North Carolina clinical trials actively recruiting patient volunteers.

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Found 27 clinical trials
Study to Evaluate Safety Tolerability and Efficacy of TAK-079 in Participants With Persistent/Chronic Primary Immune Thrombocytopenia

The purpose of this study is to evaluate the safety and tolerability of TAK-079 in participants with persistent/chronic primary immune thrombocytopenia (ITP).

Leo W. Jenkins Cancer Center
 (2.7 away) Contact site
  • 0 views
  • 27 Jan, 2021
  • +30 other locations
Prospective Trial of Rituximab for Primary Pulmonary Alveolar Proteinosis

The purpose of this study is to determine whether the use of rituximab is effective in treating pulmonary alveolar proteinosis by leading to an improvement in lung function and disease status.

East Carolina University
 (2.7 away) Contact site
  • 2 views
  • 07 Nov, 2020
  • 1 location
Efficacy and Safety of NYX-2925 in Subjects With Neuropathic Pain Associated With Diabetic Peripheral Neuropathy (DPN)

To evaluate the efficacy of NYX-2925 versus placebo in treating the neuropathic pain associated with diabetic peripheral neuropathy.

Aptinyx Clinical Site
 (2.7 away) Contact site
  • 73 views
  • 04 Jun, 2021
  • +51 other locations
A Clinical Efficacy and Safety Study of SHP607 in Preventing Chronic Lung Disease in Extremely Premature Infants

The purpose of this study is to determine if an investigational drug can reduce the burden of chronic lung disease in extremely premature babies through 12 months corrected age (CA), as compared to extremely premature babies receiving standard neonatal care alone.

premature birth
pulmonary disease
chronic lung disease
prematurity
investigational drug
Vidant Medical Center
 (2.7 away) Contact site
  • 33 views
  • 01 Jun, 2021
  • +52 other locations
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphomas or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

autologous stem cell infusion
cns tumors
ensartinib
alpha-fetoprotein
selumetinib
East Carolina University
 (2.7 away) Contact site
  • 990 views
  • 16 Jun, 2021
  • +113 other locations
Veliparib Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

This phase II trial studies how well veliparib, radiation therapy, and temozolomide work in treating patients with newly diagnosed malignant glioma without H3 K27M or BRAFV600 mutations. Poly adenosine diphosphate (ADP) ribose polymerases (PARPs) are proteins that help repair DNA mutations. PARP inhibitors, such as veliparib, can keep PARP from …

malignant glioma
epilepsy
tumor cells
cancer
temozolomide
East Carolina University
 (2.7 away) Contact site
  • 403 views
  • 16 Jun, 2021
  • +110 other locations
Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven Medulloblastoma

This phase II trial studies how well reduced doses of radiation therapy to the brain and spine (craniospinal) and chemotherapy work in treating patients with newly diagnosed type of brain tumor called WNT)/Wingless (WNT)-driven medulloblastoma. Recent studies using chemotherapy and radiation therapy have been shown to be effective in treating …

cyclophosphamide
anticonvulsants
tumor cells
medulloblastoma
cancer
East Carolina University
 (2.5 away) Contact site
  • 119 views
  • 03 Jun, 2021
  • +134 other locations
Efficacy and Safety of TD-1473 in Crohn's Disease

A Phase 2 study to evaluate the efficacy, safety and tolerability of TD-1473 in subjects with moderately-to-severely active Crohn's Disease with up to 48 weeks of treatment.

mercaptopurine
crohn's disease
conventional treatment
immunomodulators
aminosalicylate
Theravance Biopharma Investigational Site
 (2.7 away) Contact site
  • 317 views
  • 28 Jan, 2021
  • +208 other locations
Botulinum Toxin Type A (AGN-151607) for the Prevention of Post-operative Atrial Fibrillation in Patients Undergoing Open-chest Cardiac Surgery (NOVA)

This is a multi-center, randomized, double-blind, placebo-controlled, parallel group, dose-ranging study to evaluate the efficacy and safety of botulinum toxin type A (AGN-151607) injections into the epicardial fat pads, foci of ganglionic plexi, to prevent Post-Operative Atrial Fibrillation (POAF) in patients undergoing open-chest cardiac surgery.

East Carolina University
 (2.7 away) Contact site
  • 3 views
  • 24 Apr, 2021
  • +39 other locations
A Phase 2b Diabetic Kidney Disease Study

A Phase 2b Randomized, Double-blind, Placebo-controlled, Study to Evaluate the Efficacy and Safety of MEDI3506 in Subjects with Diabetic Kidney Disease

nephropathy
diabetic nephropathy
Research Site
 (2.7 away) Contact site
  • 54 views
  • 20 May, 2021
  • +115 other locations